Review
Clinical Neurology
Serena Scarpelli, Valentina Alfonsi, Maurizio Gorgoni, Luigi De Gennaro
Summary: This article summarizes the open questions in neuroscientific study of dreaming. It discusses the association between specific brain features and dream experience as well as the relationship between dreaming and waking experiences. The limitations of indirect access to dreaming and the connection between parasomnia events and dream contents are also highlighted. The article emphasizes the need for further research in dream science to establish a uniform protocol, explore advanced techniques for dream manipulation, clarify the relationship between parasomnia and dreaming, and determine the clinical significance of dreams.
JOURNAL OF SLEEP RESEARCH
(2022)
Review
Oncology
Pontus Aspenstrom
Summary: For many years, the role of RHO GTPases in cancer has been overlooked, but recent studies have shown that they are altered in many cancer types and may have oncogenic effects. This review article summarizes the current knowledge of these mutant RHO GTPases, focusing on how their kinetics can contribute to cancer progression.
Article
Chemistry, Physical
Mainak Chatterjee, Anirban Sain
Summary: Dynamic pattern formations in multicellular systems and embryos at their single-cell stage can be modeled using reaction-diffusion networks.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Joern Bonse, Stephan Graef
Summary: Laser-induced periodic surface structures (LIPSS) provide a simple and robust method for nanostructuring of solids, with various applications. However, challenges exist in controlling processing and long-term stability, requiring further research and development for industrial adoption.
Article
Chemistry, Multidisciplinary
Huiping He, Chengjian Zhou, Xi Chen
Summary: This article introduces a targeted protein degradation method based on the autophagy pathway, which overcomes the limitations of current small-molecule degraders and can degrade unligandable proteins. By designing an intelligent nanobody chimera called ATNC, researchers have successfully achieved selective degradation of intracellular targets and demonstrated its therapeutic potential in suppressing ovarian cancer cell proliferation and migration.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Immunology
Rana El Masri, Jerome Delon
Summary: Ras homology (RHO) GTPases play crucial roles in triggering multiple immune functions through interactions with effectors and kinases, and recent discoveries of new partners and genetic mutations in RHO GTPase signaling hubs offer novel therapeutic opportunities.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Neurosciences
Pamela J. Urrutia, Felipe Bodaleo, Daniel A. Borquez, Yuta Homma, Victoria Rozes-Salvador, Cristopher Villablanca, Cecilia Conde, Mitsunori Fukuda, Christian Gonzalez-Billault
Summary: The acquisition of neuronal polarity is a complex process depending on cytoskeletal dynamics and membrane traffic regulation. A positive feedback loop between Rab8a and Cdc42, coupled by Tuba, plays a crucial role in ensuring single axon generation. These findings suggest Tuba coordinates vesicular traffic and cytoskeleton dynamics during neuronal polarization.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Cell Biology
Andrew J. Neumann, Rytis Prekeris
Summary: The regulation of machinery involved in cell migration is crucial for maintaining proper organism function. Among the various structures involved, the actin cytoskeleton plays a vital role in providing the forces necessary for cells to migrate. While the Rho family of GTPases are considered the major regulators, other proteins such as the Rab40 family have also been identified as modulators of actin structures and cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Rie Seyama, Masashi Nishikawa, Yuri Uchiyama, Keisuke Hamada, Yuka Yamamoto, Masahiro Takeda, Takanori Ochi, Monami Kishi, Toshifumi Suzuki, Kohei Hamanaka, Atsushi Fujita, Naomi Tsuchida, Eriko Koshimizu, Kazuharu Misawa, Satoko Miyatake, Takeshi Mizuguchi, Shintaro Makino, Takashi Yao, Hidenori Ito, Atsuo Itakura, Kazuhiro Ogata, Koh-ichi Nagata, Naomichi Matsumoto
Summary: This study identified a rare RAC1 variant in a male patient, resulting in multiple anomalies and respiratory failure leading to death. The variant may deactivate downstream signals and affect normal cellular functions.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Robin Caire, Elisa Dalix, Marwa Chafchafi, Mireille Thomas, Marie-Therese Linossier, Myriam Normand, Alain Guignandon, Laurence Vico, Hubert Marotte
Summary: This study reveals the critical role of transcription co-factors YAP/TAZ in the signaling of pro-inflammatory cytokine TNF, and their involvement in biological effects associated with cancer and inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Chao Mei, Chong Liu, Ying Gao, Wen-Ting Dai, Wei Zhang, Xi Li, Zhao-Qian Liu
Summary: This study revealed that eIF3a is overexpressed in colorectal cancer tissues, and its high expression is associated with tumor metastasis and overall survival. Downregulation of eIF3a significantly inhibits the proliferation and migration of malignant cells. Mechanistically, eIF3a regulates Cdc42 and RhoA expression to promote actin cytoskeleton remodeling, facilitating cancer cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Mathematics, Applied
Keith Burns, Vladimir S. Matveev
Summary: This paper surveys open problems and questions related to geodesics defined by Riemannian, Finsler, semi-Riemannian and magnetic structures on manifolds. It is an extended report on the problem sessions held during the International Workshop on Geodesics in August 2010 at the Chern Institute of Mathematics in Tianjin.
ERGODIC THEORY AND DYNAMICAL SYSTEMS
(2021)
Article
Cell Biology
Chien Fung Chong, Nik Yasmin Umaira Hasnizan, Ana Masara Ahmad Mokhtar
Summary: This study utilizes scientometric analysis to explore the association between the Rho GTPase signalling system and autoimmunity, as well as investigate past research trends. The findings suggest an increasing number of publications in this field since 2006. The United States has emerged as the primary contributor in advancing our understanding of this association. Research has primarily focused on therapeutic interventions and leukocyte and endothelial remodelling.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Andy Gobel, Romy M. Riffel, Lorenz C. Hofbauer, Tilman D. Rachner
Summary: Breast cancer has a high incidence among women, and the mevalonate pathway plays a crucial role in its treatment. This review discusses the impact of the mevalonate pathway on breast cancer biology and the use of inhibiting drugs in precision therapy.
Article
Multidisciplinary Sciences
Rocio G. Sampayo, Mason Sakamoto, Madeline Wang, Sanjay Kumar, David V. Schaffer
Summary: During the process of cell differentiation into tissues, cells are influenced by mechanical signals from the extracellular matrix (ECM), which regulate their fate. The activation of Rho GTPases plays a key role in sensing these cues, but the regulation and integration of the activation dynamics is still unclear. This study found that ECM stiffness cues not only alter the magnitude but also the temporal frequency of RhoA and Cdc42 activation in adult neural stem cells (NSCs). Further experiments using optogenetics showed that the frequency of RhoA and Cdc42 activation drives astrocytic versus neuronal differentiation, highlighting the functional significance of these dynamics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Campbell D. Lawson, Anne J. Ridley
JOURNAL OF CELL BIOLOGY
(2018)
Article
Biology
Virginia Tajadura-Ortega, Ritu Garg, Richard Allen, Claudia Owczarek, Michael D. Bright, Samuel Kean, Aisyah Mohd-Noor, Anita Grigoriadis, Timothy C. Elston, Klaus M. Hahn, Anne J. Ridley
Article
Cell Biology
Narendra Suryavanshi, Joanna Furmston, Anne J. Ridley
Article
Cell Biology
Lisa Leinhos, Johannes Peters, Sabine Krull, Lena Helbig, Melanie Vogler, Magdolna Levay, Gijsbert J. van Belle, Anne J. Ridley, Susanne Lutz, Doerthe M. Katschinski, Anke Zieseniss
JOURNAL OF CELL SCIENCE
(2019)
Article
Medicine, Research & Experimental
Serena Lucotti, Camilla Cerutti, Magali Soyer, Ana M. Gil-Bernabe, Ana L. Gomes, Philip D. Allen, Sean Smart, Bostjan Markelc, Karla Watson, Paul C. Armstrong, Jane A. Mitchell, Timothy D. Warner, Anne J. Ridley, Ruth J. Muschel
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Biochemistry & Molecular Biology
Raquel B. Haga, Ritu Garg, Francesca Collu, Barbara Borda D'Agua, Sofia T. Menendez, Audrey Colomba, Franca Fraternali, Anne J. Ridley
BIOCHEMICAL JOURNAL
(2019)
Article
Oncology
Ana Paula Nunes Rodrigues Alves, Jaqueline Cristina Fernandes, Bruna Alves Fenerich, Juan Luiz Coelho-Silva, Priscila Santos Scheucher, Belinda Pinto Simoes, Eduardo Magalhaes Rego, Anne J. Ridley, Joao Agostinho Machado-Neto, Fabiola Traina
Article
Cardiac & Cardiovascular Systems
Gabriela Leao Santos, Svenja Hartmann, Wolfram-Hubertus Zimmermann, Anne Ridley, Susanne Lutz
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Oncology
Daniel J. Turnham, William W. Yang, Julia Davies, Athina Varnava, Anne J. Ridley, R. Steven Conlan, Richard W. E. Clarkson
Article
Cell Biology
Ritu Garg, Chuay-Yeng Koo, Elvira Infante, Caterina Giacomini, Anne J. Ridley, Jonathan D. H. Morris
JOURNAL OF CELL SCIENCE
(2020)
Review
Cell Biology
Natasha S. Clayton, Anne J. Ridley
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Nabila Kazmi, Tim Robinson, Jie Zheng, Siddhartha Kar, Richard M. Martin, Anne J. Ridley
Summary: This study found evidence of a potential causal relationship between Rho GTPase gene expression and breast cancer risk, with increased RHOD gene expression associated with overall and ER+ breast cancer risk, while CDC42 gene expression may have a protective effect. These findings should be validated in independent samples and further investigated biologically.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Fabiola Gonzalez-Herrera, Natasha S. Clayton, Daniela Guzman-Rivera, Ileana Carrillo, Christian Castillo, Mabel Catalan, Renatto Anfossi, Helena Quintero-Pertuz, Maria Elena Quilaqueo, Claudio Olea-Azar, Mario Rivera-Meza, Ulrike Kemmerling, Anne J. Ridley, Raul Vivar, Juan Diego Maya
Summary: This study demonstrates that statins can inhibit ROCK activity, reduce inflammation, and promote anti-inflammatory cytokine expression, suggesting that statins may be a potential pharmacological strategy for preventing cardiac inflammation in CCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Economics
Luis Buendia
SOCIO-ECONOMIC REVIEW
(2020)
Article
Hematology
Silvia Mele, Stephen Devereux, Andrea G. Pepper, Elvira Infante, Anne J. Ridley
