Article
Cardiac & Cardiovascular Systems
Michael Hauke, Robert Eckenstaler, Anne Ripperger, Anna Ender, Heike Braun, Ralf A. Benndorf
Summary: This study demonstrates that increased RhoA activity has the potential to trigger endothelial dysfunction and anti-angiogenic effects independently of its well-known downstream effectors ROCK and LIMK.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Yuka Terada, Katsutoshi Yayama
Summary: The study revealed that Ang II induces vasoconstriction in pressure-overloaded rat thoracic aortas through activation of Rho kinase and involvement of EGFR, Erk1/2, and JAK2. Additionally, the increased protein levels of MYPT1 and JAK2 in thoracic aortas of pressure-overloaded rats may contribute to the enhanced Ang II-induced contraction.
Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Hyunsoo Jang, Youngjun Park, Jaebong Jang
Summary: This review provides a current understanding of the role and mechanism of serum and glucocorticoid-regulated kinase 1 (SGK1), as well as its significance in sodium transport, cancer progression, and autoimmunity. Additionally, it summarizes the development of SGK1 inhibitors and their potential as drugs for the treatment of clinically relevant diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Shayan Nik Akhtar, Qun Lu
Summary: This study found that the RhoA signaling is dysregulated in Alzheimer's disease (AD) and is associated with spatial distribution along the rostral-caudal plane. The expression pattern of RhoA and LIMK varies from the cortex to the dentate gyrus. pRhoA shows dynamic redistribution between the nucleus and cytoplasm, while pLIMK demonstrates changes in expression level in different regions.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Psychology, Developmental
Craig A. Erickson, Charles R. Tessier, Christina Gross, Ernest Pedapati, Logan K. Wink, Kelli C. Dominick, Rebecca C. Shaffer, Hilary Rosselot, Michael P. Hong, Andrew P. Bantel, Elizabeth Berry-Kravis, Paul S. Horn, Ryan Adams, John A. Sweeney
Summary: This study investigated the activity of ERK1/2 in autism spectrum disorder (ASD). The results showed that lymphocytic ERK1/2 activation was faster in individuals with ASD, and this was correlated with greater social impairment. The differences in ERK1/2 activation were more pronounced in younger individuals.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Yuzhen Niu, Hongfang Ji
Summary: In this review, the importance of the ERK1/2 signaling pathway in the treatment of various diseases and the current research on ERK1/2 inhibitors are summarized. The main approaches used to discover ERK inhibitors, including the advantages of computer-aided drug design, are also discussed.
DRUG DISCOVERY TODAY
(2022)
Article
Medicine, Research & Experimental
Jieun Jeon, Tamanna Jahan Mony, Eunbi Cho, Huiyoung Kwon, Wan-Seob Cho, Ji Woong Choi, Byeong C. Kim, Jong Hoon Ryu, Se Jin Jeon, Kyoung Ja Kwon, Chan Young Shin, Se Jin Park, Dong Hyun Kim
Summary: In this study, it was found that rubrofusarin enhances learning and memory in mice and promotes neurite outgrowth. These effects may be achieved through activation of the ERK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Andrea Lopez-Lopez, Rita Valenzuela, Ana Isabel Rodriguez-Perez, Maria J. Guerra, Jose Luis Labandeira-Garcia, Ana Munoz
Summary: Statins have been proposed for the treatment of L-DOPA-induced dyskinesia (LID), and their anti-dyskinetic effects may be related to the inhibition of the Ras-ERK pathway. The mechanisms responsible for the anti-LID effect are unclear, but they could involve changes in cholesterol homeostasis and oxidative stress- and inflammation-related mechanisms. Angiotensin II, cholesterol, and Rho-kinase pathways have been found to interact in LID, and their inhibition by specific drugs may attenuate the dyskinetic symptoms.
Article
Biochemistry & Molecular Biology
Hidenori Kanno, Sei Naito, Yutaro Obara, Hiromi Ito, Osamu Ichiyanagi, Takafumi Narisawa, Tomoyuki Kato, Akira Nagaoka, Norihiko Tsuchiya
Summary: ERK5 has been found to be highly expressed in clear cell renal cell carcinoma (ccRCC) and is associated with high grade, high recurrence rate, and high cancer-specific survival. The expression of ERK5 is regulated by miR-143. Inhibition of ERK5 holds promise as a potential target for ccRCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Chao Liu, Fanqi Hu, Genlong Jiao, Yue Guo, Pan Zhou, Yuning Zhang, Zhen Zhang, Jing Yi, Yonggang You, Zhizhong Li, Hua Wang, Xuesong Zhang
Summary: Stem cell-derived exosomes have potential in treating spinal cord injury by reducing reactive oxygen species and suppressing M1 macrophage polarization. Dental pulp stem cell-derived exosomes can reduce macrophage M1 polarization by disrupting the ROS-MAPK-NF kappa B P65 signaling pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jiafeng Zhu, Qian Li, Yan Sun, Shiyu Zhang, Ruiyan Pan, Yanguang Xie, Jinyan Chen, Lihong Shi, Yanbo Chen, Zhipeng Sun, Lane Zhang
Summary: This study investigates the molecular mechanism of IGF1R in Ang II-induced cardiac fibrosis and demonstrates that IGF1R deficiency alleviates cardiac fibrosis. The results suggest that IGF1R may be a promising therapeutic target for cardiac fibrosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Toxicology
Yujia Xie, Jixuan Ma, Meng Yang, Lieyang Fan, Weihong Chen
Summary: Silicosis is a scarring lung disease caused by inhaling fine particles of crystalline silica in the workplace. The underlying molecular mechanisms of silicosis are not fully understood, but recent studies have highlighted the role of the activated ERK signaling pathway in regulating oxidative stress, inflammatory response, fibroblast activation, and other processes involved in the formation and development of silicosis.
TOXICOLOGY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Ruoqi Yang, Guiping Zhao, Lili Zhang, Yu Xia, Huijuan Yu, Bin Yan, Bin Cheng
Summary: This study constructed an efficient and reliable multi-stage virtual screening-in vitro biological validation system to identify potential inhibitors targeting ERK2. By using machine learning models, ADME/T prediction, and molecular docking, several candidate inhibitors were identified from natural products, and one of them exhibited acceptable inhibitory activity in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)