Rodent models of neuroinflammation for Alzheimer’s disease

Systemic lipopolysaccharide administration impairs retrieval of context–object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation

(2015) Jennifer Czerniawski et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

(2015) Diana M. Norden et al.   NEUROPHARMACOLOGY

Human CNS immune senescence and neurodegeneration

(2014) Wolfgang J Streit et al.   CURRENT OPINION IN IMMUNOLOGY

Molecular and Cellular Mechanism of Okadaic Acid (OKA)-Induced Neurotoxicity: A Novel Tool for Alzheimer’s Disease Therapeutic Application

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Mechanism of synapse redox stress in Okadaic acid (ICV) induced memory impairment: Role of NMDA receptor

(2014) Pradip K. Kamat et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of Naproxen on Immune Responses in a Colchicine-Induced Rat Model of Alzheimer's Disease

(2014) Susmita Sil et al.   NEUROIMMUNOMODULATION

Microglia change from a reactive to an age-like phenotype with the time in culture

(2014) Cláudia Caldeira et al.   Frontiers in Cellular Neuroscience

Correlated Inflammatory Responses and Neurodegeneration in Peptide-Injected Animal Models of Alzheimer’s Disease

(2014) James G. McLarnon   Biomed Research International

Protein phosphatase 2A dysfunction in Alzheimer’s disease

(2014) Jean-Marie Sontag et al.   Frontiers in Molecular Neuroscience

Phagocyte dysfunction, tissue aging and degeneration

(2013) Wei Li   AGEING RESEARCH REVIEWS

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

(2013) Victoria E. Johnson et al.   BRAIN

Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice

(2013) N. Rajasekar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of 3xTg-AD Mice

(2013) Yanxing Chen et al.   MOLECULAR NEUROBIOLOGY

Aβ-independent processes—rethinking preclinical AD

(2013) Gaël Chételat   Nature Reviews Neurology

Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem

(2013) Isabelle Bardou et al.   NEUROBIOLOGY OF AGING

Microglia are the major source of TNF-α and TGF-β1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin

(2013) Jennifer V. Welser-Alves et al.   NEUROCHEMISTRY INTERNATIONAL

Okadaic acid-induced Tau phosphorylation in rat brain: Role of NMDA receptor

(2013) P.K. Kamat et al.   NEUROSCIENCE

Xanthoceraside attenuates tau hyperphosphorylation and cognitive deficits in intracerebroventricular-streptozotocin injected rats

(2013) Peng Liu et al.   PSYCHOPHARMACOLOGY

Pathogenesis and Disease-modifying Therapy in Alzheimer's Disease: The Flat Line of Progress

(2012) Rudy J. Castellani et al.   ARCHIVES OF MEDICAL RESEARCH

A Dual Mechanism Linking NGF/proNGF Imbalance and Early Inflammation to Alzheimer's Disease Neurodegeneration in the AD11 Anti-NGF Mouse Model

(2012) S. Capsoni et al.   CNS & Neurological Disorders-Drug Targets

Neuroinflamm-Aging and Neurodegenerative Diseases: An Overview

(2012) Vincenzo Pizza et al.   CNS & Neurological Disorders-Drug Targets

Does a Pro-Inflammatory Process Precede Alzheimers Disease and Mild Cognitive Impairment?

(2012) M. T. Ferretti et al.   Current Alzheimer Research

Pretreatment with Memantine Prevents Alzheimer-Like Alterations Induced by Intrahippocampal Okadaic Acid Administration in Rats

(2012) Eduardo Rigon Zimmer et al.   Current Alzheimer Research

Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats

(2012) Pradeep Kumar Kamat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus

(2012) Cristina Pintado et al.   Journal of Neuroinflammation

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

(2012) Dimitrije Krstic et al.   Journal of Neuroinflammation

Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration

(2012) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

A study on neuroinflammatory marker in brain areas of okadaic acid (ICV) induced memory impaired rats

(2012) Pradeep Kumar Kamat et al.   LIFE SCIENCES

A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)

(2012) Yanxing Chen et al.   MOLECULAR NEUROBIOLOGY

Deciphering the mechanism underlying late-onset Alzheimer disease

(2012) Dimitrije Krstic et al.   Nature Reviews Neurology

Animal systems in the development of treatments for Alzheimer's disease: challenges, methods, and implications

(2012) Jonathan J. Sabbagh et al.   NEUROBIOLOGY OF AGING

Lipopolysaccharide induces paired immunoglobulin-like receptor B (PirB) expression, synaptic alteration, and learning–memory deficit in rats

(2012) X.-H. Deng et al.   NEUROSCIENCE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

(2012) Latha Devi et al.   PLoS One

The Neuron-Astrocyte-Microglia Triad in Normal Brain Ageing and in a Model of Neuroinflammation in the Rat Hippocampus

(2012) Francesca Cerbai et al.   PLoS One

Neuroglial alterations in rats submitted to the okadaic acid-induced model of dementia

(2011) Ana Paula Costa et al.   BEHAVIOURAL BRAIN RESEARCH

Interleukin-6 trans-signaling in the senescent mouse brain is involved in infection-related deficits in contextual fear conditioning

(2011) Michael D. Burton et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer’s Disease in Rats

(2011) Dinesh Kumar Dhull et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease: a long-term follow up study

(2011) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

A Lifespan Approach to Neuroinflammatory and Cognitive Disorders: A Critical Role for Glia

(2011) Staci D. Bilbo et al.   Journal of Neuroimmune Pharmacology

Chronic IL-1β-Mediated Neuroinflammation Mitigates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease without Inducing Overt Neurodegeneration

(2011) Sarah B. Matousek et al.   Journal of Neuroimmune Pharmacology

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Midlife overweight and obesity increase late-life dementia risk: A population-based twin study

(2011) W. L. Xu et al.   NEUROLOGY

Induction of oxidative DNA damage by the marine toxin okadaic acid depends on human cell type

(2011) Vanessa Valdiglesias et al.   TOXICON

Metabolome in progression to Alzheimer's disease

(2011) M Orešič et al.   Translational Psychiatry

Contribution of systemic inflammation to chronic neurodegeneration

(2010) V. Hugh Perry   ACTA NEUROPATHOLOGICA

Alzheimer's disease: Old problem, new views from transgenic and viral models

(2010) Tomasz Jaworski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Interleukin 18 in the CNS

(2010) Silvia Alboni et al.   Journal of Neuroinflammation

Transgenic Mice with Chronic NGF Deprivation and Alzheimer's Disease-Like Pathology Display Hippocampal Region-Specific Impairments in Short- and Long-Term Plasticities

(2010) G. Houeland et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

How does diabetes accelerate Alzheimer disease pathology?

(2010) Catrina Sims-Robinson et al.   Nature Reviews Neurology

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

(2010) Piet Eikelenboom et al.   Neurodegenerative Diseases

Late Prenatal Immune Activation in Mice Leads to Behavioral and Neurochemical Abnormalities Relevant to the Negative Symptoms of Schizophrenia

(2010) Byron KY Bitanihirwe et al.   NEUROPSYCHOPHARMACOLOGY

Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration

(2010) S. Capsoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

(2010) M. T. Heneka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Toll-Like Receptor 3-Mediated Immunity during Gestation Inhibits Cortical Neurogenesis and Causes Behavioral Disturbances

(2010) J. De Miranda et al.   mBio

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Inflammation in transgenic mouse models of neurodegenerative disorders

(2009) Claudia Schwab et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Okadaic acid (ICV) induced memory impairment in rats: A suitable experimental model to test anti-dementia activity

(2009) Pradeep K. Kamat et al.   BRAIN RESEARCH

Searching for new animal models of Alzheimer′s disease

(2009) Roberta Epis et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

(2009) Corinne G. Jolivalt et al.   EXPERIMENTAL NEUROLOGY

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

Early inflammation and immune response mRNAs in the brain of AD11 anti-NGF mice

(2009) Mara D’Onofrio et al.   NEUROBIOLOGY OF AGING

Sustained expression of interleukin-1β in mouse hippocampus impairs spatial memory

(2009) A.H. Moore et al.   NEUROSCIENCE

Neurodegeneration and Neuroinflammation in cdk5/p25-Inducible Mice

(2008) David Muyllaert et al.   AMERICAN JOURNAL OF PATHOLOGY

Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation

(2008) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons

(2008) Alexis M Stranahan et al.   NATURE NEUROSCIENCE

Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits

(2008) Yuxin Liu et al.   NEUROTOXICOLOGY

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

(2007) Johanna Ojala et al.   NEUROBIOLOGY OF AGING