Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas

Whole-genome landscape of pancreatic neuroendocrine tumours

(2017) Aldo Scarpa et al.   NATURE

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

The Genetic Program of Pancreatic β-Cell Replication In Vivo

(2016) Agnes Klochendler et al.   DIABETES

Histologic and Molecular Profile of Pediatric Insulinomas: Evidence of a Paternal Parent-of-Origin Effect

(2016) Tricia R. Bhatti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Development and clinical application of an integrative genomic approach to personalized cancer therapy

(2016) Andrew V. Uzilov et al.   Genome Medicine

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function

(2015) Dana Avrahami et al.   Cell Metabolism

Trithorax and Polycomb group-dependent regulation: a tale of opposing activities

(2015) S. J. Geisler et al.   DEVELOPMENT

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Frequency and Clinical Correlates of Somatic Ying Yang 1 Mutations in Sporadic Insulinomas

(2015) Urs D. Lichtenauer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Polycomb recruitment at the Class II transactivator gene

(2015) Nathaniel H. Boyd et al.   MOLECULAR IMMUNOLOGY

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Diabetes mellitus—advances and challenges in human β-cell proliferation

(2015) Peng Wang et al.   Nature Reviews Endocrinology

Neomorphic effects of recurrent somatic mutations inYin Yang 1in insulin-producing adenomas

(2015) M. Kyle Cromer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of predicted protein-truncating genetic variants on the human transcriptome

(2015) M. A. Rivas et al.   SCIENCE

EpiFactors: a comprehensive database of human epigenetic factors and complexes

(2015) Yulia A. Medvedeva et al.   Database-The Journal of Biological Databases and Curation

Analytical validation of whole exome and whole genome sequencing for clinical applications

(2014) Michael D Linderman et al.   BMC Medical Genomics

Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication

(2014) Dana Avrahami et al.   JOURNAL OF CLINICAL INVESTIGATION

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The UCSC Genome Browser database: 2015 update

(2014) Kate R. Rosenbloom et al.   NUCLEIC ACIDS RESEARCH

Ensembl 2015

(2014) Fiona Cunningham et al.   NUCLEIC ACIDS RESEARCH

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

(2014) J. Fadista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data

(2013) Gabriela Bindea et al.   BIOINFORMATICS

Revealing selection in cancer using the predicted functional impact of cancer mutations. Application to nomination of cancer drivers

(2013) B Reva   BMC GENOMICS

Soluble Factors Secreted by T Cells Promote  -Cell Proliferation

(2013) E. Dirice et al.   DIABETES

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

(2013) A. C. Nica et al.   GENOME RESEARCH

Combined modulation of polycomb and trithorax genes rejuvenates β cell replication

(2013) Josie X. Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

A new world of Polycombs: unexpected partnerships and emerging functions

(2013) Yuri B. Schwartz et al.   NATURE REVIEWS GENETICS

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?

(2012) Frans Schuit et al.   DIABETES

When less is more: the forbidden fruits of gene repression in the adult β-cell

(2012) T. J. Pullen et al.   DIABETES OBESITY & METABOLISM

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Detecting differential usage of exons from RNA-seq data

(2012) S. Anders et al.   GENOME RESEARCH

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

(2012) D. C. Koboldt et al.   GENOME RESEARCH

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

(2012) Wenqing Fu et al.   NATURE

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Fast Computation and Applications of Genome Mappability

(2012) Thomas Derrien et al.   PLoS One

Beckwith–Wiedemann syndrome and uniparental disomy 11p: fine mapping of the recombination breakpoints and evaluation of several techniques

(2011) Valeria Romanelli et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

(2010) Nathalie M. Fiaschi-Taesch et al.   DIABETES

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

(2010) J. van Arensbergen et al.   GENOME RESEARCH

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression

(2009) Emelyne Dejeux et al.   ENDOCRINE-RELATED CANCER

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Familial Beckwith–Wiedemann syndrome due toCDKN1C mutation manifesting with recurring omphalocele

(2008) Antonio Percesepe et al.   PRENATAL DIAGNOSIS

Geometric Interpretation of Gene Coexpression Network Analysis

(2008) Steve Horvath et al.   PLoS Computational Biology

Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene

(2007) Manuel C. Lemos et al.   HUMAN MUTATION