Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore

(2016) James Lyon et al.   ENDOCRINOLOGY

High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation

(2016) Karine Robitaille et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles

(2015) Nora S. Kayton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion

(2015) Shiwani Tiwari et al.   DIABETES

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells

(2015) Hainan Chen et al.   DIABETES

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Diabetes mellitus—advances and challenges in human β-cell proliferation

(2015) Peng Wang et al.   Nature Reviews Endocrinology

Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells

(2014) Brooke A. Sullivan et al.   DIABETES

GABA Promotes Human  -Cell Proliferation and Modulates Glucose Homeostasis

(2014) I. Purwana et al.   DIABETES

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

(2014) Latif Rachdi et al.   DIABETOLOGIA

Whole Organism High Content Screening Identifies Stimulators of Pancreatic Beta-Cell Proliferation

(2014) Naoki Tsuji et al.   PLoS One

Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human  -Cell Replication in the Transplant Setting

(2013) Y. Jiao et al.   DIABETES

Human Pancreatic  -Cell G1/S Molecule Cell Cycle Atlas

(2013) N. M. Fiaschi-Taesch et al.   DIABETES

Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human  -Cell Replication: A Revised Model of Human  -Cell G1/S Control

(2013) N. M. Fiaschi-Taesch et al.   DIABETES

 -Aminobutyric Acid Regulates Both the Survival and Replication of Human  -Cells

(2013) J. Tian et al.   DIABETES

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

(2013) Weijun Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adenosine Signaling Promotes Regeneration of Pancreatic β Cells In Vivo

(2012) Olov Andersson et al.   Cell Metabolism

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adenosine kinase inhibition selectively promotes rodent and porcine islet  -cell replication

(2012) J. P. Annes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulated and Reversible Induction of Adult Human  -Cell Replication

(2011) K. K. Takane et al.   DIABETES

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

(2011) C. Dai et al.   DIABETOLOGIA

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes

(2011) N. Soltani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas

(2010) Christina U. Köhler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Parathyroid Hormone-Related Protein Enhances Human  -Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression

(2010) N. Guthalu Kondegowda et al.   DIABETES

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

(2010) Nathalie M. Fiaschi-Taesch et al.   DIABETES

Erythropoietin protects against diabetes through direct effects on pancreatic β cells

(2010) Diana Choi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serotonin regulates pancreatic beta cell mass during pregnancy

(2010) Hail Kim et al.   NATURE MEDICINE

Emerging roles for the TGFβ family in pancreatic β-cell homeostasis

(2010) Melissa L. Brown et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Survey of the Human Pancreatic  -Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human  -Cell Replication and Function In Vivo

(2009) N. Fiaschi-Taesch et al.   DIABETES

Identification of small-molecule inducers of pancreatic  -cell expansion

(2009) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and application of locally delivered agonists of the adenosine A2Areceptor

(2009) Simon Mantell et al.   Expert Review of Clinical Pharmacology

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

In Vitro Proliferation of Cells Derived From Adult Human  -Cells Revealed By Cell-Lineage Tracing

(2008) H. A. Russ et al.   DIABETES

Prolactin Receptor Is Required for Normal Glucose Homeostasis and Modulation of β-Cell Mass during Pregnancy

(2008) Carol Huang et al.   ENDOCRINOLOGY