Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

(2014) Gerrit Gehring et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa

(2014) Lilli Arndt et al.   MOLECULAR BIOLOGY OF THE CELL

The voltage-gated sodium channel TPC1 confers endolysosomal excitability

(2014) Chunlei Cang et al.   Nature Chemical Biology

Emergence of Zaire Ebola Virus Disease in Guinea

(2014) Sylvain Baize et al.   NEW ENGLAND JOURNAL OF MEDICINE

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

(2013) Peter B. Madrid et al.   PLoS One

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Potential Vaccines and Post-Exposure Treatments for Filovirus Infections

(2012) Brian M. Friedrich et al.   Viruses-Basel

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

(2011) A. S. Kondratowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ebola haemorrhagic fever

(2010) Heinz Feldmann et al.   LANCET

NAADP Receptors

(2010) A. Galione   Cold Spring Harbor Perspectives in Biology

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

(2010) Mohammad F. Saeed et al.   PLoS Pathogens

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

(2010) Asuka Nanbo et al.   PLoS Pathogens

Calcium signaling via two-pore channels: local or global, that is the question

(2009) Michael X. Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition

(2009) Osvaldo Martinez et al.   CELLULAR MICROBIOLOGY

Identification of novel cellular targets for therapeutic intervention against Ebola virus infection by siRNA screening

(2009) Andrey A. Kolokoltsov et al.   DRUG DEVELOPMENT RESEARCH

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

Repurposing with a Difference

(2009) M. S. Boguski et al.   SCIENCE

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

Cell-permeant NAADP: A novel chemical tool enabling the study of Ca2+ signalling in intact cells

(2007) Raman Parkesh et al.   CELL CALCIUM