The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix

Spontaneous Adsorption of Coiled-Coil Model Peptides K and E to a Mixed Lipid Bilayer

(2015) Kristyna Pluhackova et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Structure of a mammalian ryanodine receptor

(2014) Ran Zalk et al.   NATURE

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

(2014) Zhen Yan et al.   NATURE

The voltage-gated sodium channel TPC1 confers endolysosomal excitability

(2014) Chunlei Cang et al.   Nature Chemical Biology

Kinase activity and calmodulin binding are essential for growth signaling by the phytosulfokine receptor PSKR1

(2014) Jens Hartmann et al.   PLANT JOURNAL

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

(2014) Y. Lin-Moshier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants

(2014) W.-G. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Going Backward: A Flexible Geometric Approach to Reverse Transformation from Coarse Grained to Atomistic Models

(2013) Tsjerk A. Wassenaar et al.   Journal of Chemical Theory and Computation

Mixing MARTINI: Electrostatic Coupling in Hybrid Atomistic–Coarse-Grained Biomolecular Simulations

(2013) Tsjerk A. Wassenaar et al.   JOURNAL OF PHYSICAL CHEMISTRY B

C-Terminus-Mediated Voltage Gating of Arabidopsis Guard Cell Anion Channel QUAC1

(2013) Patrick Mumm et al.   Molecular Plant

The eukaryotic linear motif resource ELM: 10 years and counting

(2013) Holger Dinkel et al.   NUCLEIC ACIDS RESEARCH

Role of the C-terminal domain in the structure and function of tetrameric sodium channels

(2013) Claire Bagnéris et al.   Nature Communications

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Improved Parameters for the Martini Coarse-Grained Protein Force Field

(2012) Djurre H. de Jong et al.   Journal of Chemical Theory and Computation

Modulation of plant TPC channels by polyunsaturated fatty acids

(2012) Paul Vijay Kanth Gutla et al.   JOURNAL OF EXPERIMENTAL BOTANY

An N-Terminal Dileucine Motif Directs Two-Pore Channels to the Tonoplast of Plant Cells

(2012) Nina Larisch et al.   TRAFFIC

Two-pore Channels Form Homo- and Heterodimers

(2011) Katja Rietdorf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

hERG potassium channel gating is mediated by N- and C-terminal region interactions

(2011) Ahleah S. Gustina et al.   JOURNAL OF GENERAL PHYSIOLOGY

TPC1 – SV Channels Gain Shape

(2011) Rainer Hedrich et al.   Molecular Plant

A Novel Calcium Binding Site in the Slow Vacuolar Cation Channel TPC1 Senses Luminal Calcium Levels

(2011) B. Dadacz-Narloch et al.   PLANT CELL

Impact of gating modulation in CaV1.3 L-type calcium channels

(2010) Alexandra Koschak   Channels

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

(2010) Michael X. Zhu et al.   FEBS LETTERS

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

(2010) Samantha J. Pitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Roles of AtTPC1, Vacuolar Two Pore Channel 1, in Arabidopsis Stomatal Closure

(2010) M. M. Islam et al.   PLANT AND CELL PHYSIOLOGY

NAADP Receptors

(2010) A. Galione   Cold Spring Harbor Perspectives in Biology

Polarizable Water Model for the Coarse-Grained MARTINI Force Field

(2010) Semen O. Yesylevskyy et al.   PLoS Computational Biology

SV channels dominate the vacuolar Ca2+release during intracellular signaling

(2009) Igor Pottosin et al.   FEBS LETTERS

New GATEWAY vectors for High Throughput Analyses of Protein–Protein Interactions by Bimolecular Fluorescence Complementation

(2009) Christian Gehl et al.   Molecular Plant

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Thefou2mutation in the major vacuolar cation channel TPC1 confers tolerance to inhibitory luminal calcium

(2009) Diana Beyhl et al.   PLANT JOURNAL

NAADP-mediated channel ‘chatter’ in neurons of the rat medulla oblongata

(2008) G. Cristina Brailoiu et al.   BIOCHEMICAL JOURNAL

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation