Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A

(2017) Yosif Manavski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury

(2016) Andrew J. Paris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

(2016) Jiurong Liang et al.   NATURE MEDICINE

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

(2016) Jong-Seok Moon et al.   NATURE MEDICINE

Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis

(2016) Zhongwei Cao et al.   NATURE MEDICINE

Pulmonary neuroendocrine cells function as airway sensors to control lung immune response

(2016) K. Branchfield et al.   SCIENCE

FOXF1 maintains endothelial barrier function and prevents edema after lung injury

(2016) Yuqi Cai et al.   Science Signaling

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

(2016) Fuqin Fan et al.   Science Translational Medicine

FOXF1 maintains endothelial barrier function and prevents edema after lung injury

(2016) Yuqi Cai et al.   Science Signaling

A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation

(2015) Kirk J. Wangensteen et al.   GENES & DEVELOPMENT

Resetting the transcription factor network reverses terminal chronic hepatic failure

(2015) Taichiro Nishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration

(2015) Tien Peng et al.   NATURE

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Parent stem cells can serve as niches for their daughter cells

(2015) Ana Pardo-Saganta et al.   NATURE

Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration

(2015) Shahin Rafii et al.   NATURE CELL BIOLOGY

Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice

(2015) Chava Rosen et al.   NATURE MEDICINE

The proinflammatory role of HECTD2 in innate immunity and experimental lung injury

(2015) Tiffany A. Coon et al.   Science Translational Medicine

Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia

(2015) Chunbin Zou et al.   Science Translational Medicine

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

(2015) Nilgun I. Reed et al.   Science Translational Medicine

Pro-Regenerative Signaling after Acetaminophen-Induced Acute Liver Injury in Mice Identified Using a Novel Incremental Dose Model

(2014) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance

(2014) Zhongwei Cao et al.   CANCER CELL

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

(2014) Joo-Hyeon Lee et al.   CELL

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

(2014) Brigid L.M. Hogan et al.   Cell Stem Cell

Fibrosis: ultimate and proximate causes

(2014) Victor J. Thannickal et al.   JOURNAL OF CLINICAL INVESTIGATION

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

p63+Krt5+ distal airway stem cells are essential for lung regeneration

(2014) Wei Zuo et al.   NATURE

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

(2014) Andrew E. Vaughan et al.   NATURE

Mouse liver repopulation with hepatocytes generated from human fibroblasts

(2014) Saiyong Zhu et al.   NATURE

Lung regeneration: mechanisms, applications and emerging stem cell populations

(2014) Darrell N Kotton et al.   NATURE MEDICINE

Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat

(2014) J. Hu et al.   SCIENCE

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

Chitinase 3-Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis

(2014) Y. Zhou et al.   Science Translational Medicine

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Role and Regulation of PDGFRα Signaling in Liver Development and Regeneration

(2013) Prince K. Awuah et al.   AMERICAN JOURNAL OF PATHOLOGY

Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment

(2013) Juanjuan Zhao et al.   HEPATOLOGY

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic stem cell niches

(2013) Claus Kordes et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Dedifferentiation of committed epithelial cells into stem cells in vivo

(2013) Purushothama Rao Tata et al.   NATURE

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

(2013) Sarah X L Huang et al.   NATURE BIOTECHNOLOGY

A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition

(2013) Kevin Wei et al.   NATURE MEDICINE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Mouse Hepatic Oval Cells Require Met-Dependent PI3K to Impair TGF-β-Induced Oxidative Stress and Apoptosis

(2013) Adoración Martínez-Palacián et al.   PLoS One

Therapy for Fibrotic Diseases: Nearing the Starting Line

(2013) S. L. Friedman et al.   Science Translational Medicine

Peripheral Blood Mononuclear Cell Gene Expression Profiles Predict Poor Outcome in Idiopathic Pulmonary Fibrosis

(2013) J. D. Herazo-Maya et al.   Science Translational Medicine

Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats

(2012) Lin Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Pulmonary fibrosis: patterns and perpetrators

(2012) Paul W. Noble et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages: Central regulators of hepatic fibrogenesis and fibrosis resolution

(2012) Prakash Ramachandran et al.   JOURNAL OF HEPATOLOGY

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

(2012) Patricia Sancho et al.   PLoS One

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes

(2011) Jianqiang Ding et al.   JOURNAL OF CLINICAL INVESTIGATION

The three R’s of lung health and disease: repair, remodeling, and regeneration

(2011) Michael F. Beers et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

(2011) Pengyu Huang et al.   NATURE

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

(2011) Sayaka Sekiya et al.   NATURE

A hepatocyte growth factor receptor (Met)−insulin receptor hybrid governs hepatic glucose metabolism

(2011) Arlee Fafalios et al.   NATURE MEDICINE

Scraping fibrosis: Expressway to the core of fibrosis

(2011) Wajahat Z Mehal et al.   NATURE MEDICINE

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis

(2010) Amber L. Degryse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion

(2010) Kristina E. Hoot et al.   JOURNAL OF CLINICAL INVESTIGATION

FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of β-catenin expression

(2010) Muhammad K. Mirza et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE

Noninvasive molecular imaging of c-Myc activation in living mice

(2010) H. Fan-Minogue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in Fibrillin-1 Cause Congenital Scleroderma: Stiff Skin Syndrome

(2010) B. L. Loeys et al.   Science Translational Medicine

Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury

(2009) Andrés Hidalgo et al.   NATURE MEDICINE

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Generation and Regeneration of Cells of the Liver and Pancreas

(2008) K. S. Zaret et al.   SCIENCE