Editorial Material
Plant Sciences
Pooja Singh, Vipul Mishra, Durgesh Kumar Tripathi, Francisco J. Corpas, Vijay Pratap Singh
Summary: Reactive oxygen species (ROS) play a crucial role in plant development and stress response. Recent research by Li et al. showed that ROS production is regulated by receptor-like cytoplasmic kinase (RLCK)-mediated phosphorylation of respiratory burst oxidase homolog D (RBOHD), which in turn modulates plant immunity and enhances biotic stress tolerance.
TRENDS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Keum-Jin Yang, Won Jung Choi, Yoon-Kyung Chang, Cheol Whee Park, Suk Young Kim, Yu Ah Hong
Summary: Xanthine oxidase (XO) inhibition showed renoprotective effects in diabetic kidney disease (DKD) by inhibiting vascular endothelial growth factor (VEGF) and NADPH oxidase (NOX) and reducing oxidative stress. This study provides important insights into the therapeutic potential of XO inhibition in DKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Zhen-Zhen Liu, Wei Chen, Cheng-Kai Zhou, Ke Ma, Yu Gao, Yong-Jun Yang
Summary: This study revealed the importance of STING in promoting extracellular traps (ETs) formation through the ROS-ERK signaling pathway during Staphylococcus aureus infection. STING deficiency led to decreased cell-free DNA (cfDNA) level, reduced expression of citrullinated histone H3 (CitH3), and diminished DNA colocalization with CitH3 and myeloperoxidase (MPO). Additionally, STING(-/-) BMDMs exhibited increased levels of extracellular bacteria compared to WT BMDMs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Md Ahasanur Rahman, Herman Fennell, Hemayet Ullah
Summary: The scaffold protein receptor for Activated C Kinase1 (RACK1) plays a critical role in regulating various aspects of plant growth and development. Recent studies have shown that RACK1 is involved in reactive oxygen species (ROS) signaling in plants. This study investigated the connection between RACK1 and ROS balance in rice plants by analyzing T-DNA-mediated activation-tagged RACK1B overexpressed (OX) transgenic rice plants. The results showed that overexpression of OsRACK1B led to abnormalities in pollen viability, anther dehiscence, and spikelet morphology, resulting in partial spikelet sterility. The study also found that the elevated ROS levels in the transgenic plants could be attributed to NADPH oxidase. These findings suggest that optimal expression of RACK1 is crucial for fertility in rice plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tian Xie, Zehua Duan, Shilong Sun, Chengnan Chu, Weiwei Ding
Summary: The study found that beta-Lactams exert immunomodulation effects through modulating neutrophil extracellular traps (NETs) formation, depending on the PKC-Akt-mTOR signal pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ruixue Huang, Liyan Hou, Xingyue Zhai, Zhengzheng Ruan, Wei Sun, Dongdong Zhang, Xiulan Zhao, Qingshan Wang
Summary: Chronic exposure to n-hexane can cause sensorimotor neuropathy mediated by the toxic metabolite 2,5-hexanedione. The activation of NLRP3 inflammasome has been associated with various neurodegenerative diseases, and in this study, it was found that HD-induced neurotoxicity involves the activation of NLRP3 inflammasome. Inhibition of NADPH oxidase can mitigate the activation of NLRP3 inflammasome and subsequent neurodegeneration, suggesting a critical role of NADPH oxidase-dependent activation of microglial NLRP3 inflammasome in HD-induced neurotoxicity.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Elena Daveri, Ana M. Adamo, Eugenia Alfine, Wei Zhu, Patricia Oteiza
Summary: The study found that hexameric PAC can inhibit proliferation and promote apoptosis of colorectal cancer cells by reducing the activity of the EGFR signaling pathway. It affects EGFR localization, promotes EGFR internalization, and synergizes with EGFR-targeted drugs, demonstrating anti-CRC effects.
Article
Biochemistry & Molecular Biology
Jiuchun Qiu, Daiqi Liu, Pengsha Li, Lingling Zhou, Lu Zhou, Xing Liu, Yue Zhang, Meng Yuan, Gary Tse, Guangping Li, Tong Liu
Summary: Oxidative stress and mitochondrial dysfunction play important roles in the development of diabetic cardiomyopathy in type 2 diabetes mellitus. This study established a type 2 diabetes model and found that inhibiting NADPH oxidase can improve ventricular remodeling and reduce the incidence of DCM.
Article
Immunology
Weam W. IbrahimnAff, Nora O. Abdel RasheednAff
Summary: The study explored the neuroprotective effects of diapocynin, a specific NADPH oxidase inhibitor, against the 3-nitropropionic acid (3-NP) model of Huntington's disease (HD) in rats. The results showed that diapocynin attenuated oxidative stress, neuroinflammation, glial activation, and apoptosis induced by 3-NP. Diapocynin also improved motor functions and histopathological derangements associated with HD. The findings suggest that diapocynin could be a promising candidate for the management of HD.
INFLAMMOPHARMACOLOGY
(2022)
Article
Cell Biology
Ruijie Zhang, Chunxiao Liu, Liu Yang, Tong Ji, Nana Zhang, Xiaoqing Dong, Xin Chen, Jing Ma, Wei Gao, Shile Huang, Long Chen
Summary: Research shows that PD toxins induce neuronal apoptosis by generating H2O2 through NOX2, hindering the AMPK/Akt-mTOR signaling pathway. Inhibiting NOX2 or using antioxidants may help alleviate neuronal loss caused by oxidative stress.
CELLULAR SIGNALLING
(2022)
Article
Pharmacology & Pharmacy
Hui Zheng, Nannan Xu, Zihao Zhang, Fen Wang, Jie Xiao, Xiaoping Ji
Summary: This study found that GKT137831 can alleviate DOX-induced cardiomyocyte apoptosis by inhibiting NOX1/4-driven ROS production. The upregulation of the MAPK pathway induced by NOX1/4-derived ROS production may be the potential mechanism of GKT137831 action. GKT137831 may be a potential drug candidate to ameliorate DOX-induced cardiotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Fan Huang, Guan Wang, Lu Ding, Zi-Ran Bai, Yi Leng, Jun-Wei Tian, Jian-Zeng Zhang, Yan-Qi Li, Yuan-Hua Qin, Xia Li, Xin Qi
Summary: Increasing evidence suggests that metabolic factors are involved in the pathological process of osteoarthritis (OA). This study confirms the elevated levels of lactate in OA patients and its correlation with other metabolic markers. Lactate can up-regulate specific receptors and activate signaling pathways leading to oxidative stress and chondrocyte damage.
Article
Biochemistry & Molecular Biology
Randa Belgacemi, Soula Danopoulos, Gail Deutsch, Ian Glass, Valerian Dormoy, Saverio Bellusci, Denise Al Alam
Summary: The Hedgehog signaling pathway is essential for mouse lung development, and this study found similar expression patterns in human lung development. Inhibiting the Hedgehog signaling pathway in human lung development resulted in reduced branching and dysregulated epithelial-mesenchymal markers and related signaling pathways. These findings are important for exploring therapeutic targets for childhood pulmonary diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Developmental Biology
Emily K. Ho, Tim Stearns
Summary: Vertebrate Hedgehog signaling mechanisms are closely linked to the biology of the primary cilium, which imposes temporal and spatial constraints on the signaling pathway in developing tissues.
Article
Neurosciences
Yuri Zilberter, Dennis R. Tabuena, Misha Zilberter
Summary: Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are difficult to treat due to a lack of understanding of their primary initiating factors. Recent research suggests that early oxidative stress caused by NADPH oxidase (NOX) activation may be a shared initiating mechanism among major sporadic NDDs. This study focuses on Alzheimer's disease (AD), Parkinson's disease (PD), and acquired epilepsy, and explores the commonalities in neuroinflammation and NOX involvement to identify therapeutic targets and gain a deeper understanding of the underlying causes of NDDs.
PROGRESS IN NEUROBIOLOGY
(2023)