Advances in Microfluidics Applied to Single Cell Operation

Deterministic trapping, encapsulation and retrieval of single-cells

(2017) M. Sauzade et al.   LAB ON A CHIP

Automated 3D-printed unibody immunoarray for chemiluminescence detection of cancer biomarker proteins

(2017) C. K. Tang et al.   LAB ON A CHIP

Microfluidic chip based micro RNA detection through the combination of fluorescence and surface enhanced Raman scattering techniques

(2017) Zhile Wang et al.   NANOTECHNOLOGY

A review on continuous-flow microfluidic PCR in droplets: Advances, challenges and future

(2016) Yonghao Zhang et al.   ANALYTICA CHIMICA ACTA

Optimization of Surface-Enhanced Raman Spectroscopy Conditions for Implementation into a Microfluidic Device for Drug Detection

(2016) Neal D. Kline et al.   ANALYTICAL CHEMISTRY

Microfluidic Platform with In-Chip Electrophoresis Coupled to Mass Spectrometry for Monitoring Neurochemical Release from Nerve Cells

(2016) Xiangtang Li et al.   ANALYTICAL CHEMISTRY

Single-Cell Isolation of Circulating Tumor Cells from Whole Blood by Lateral Magnetophoretic Microseparation and Microfluidic Dispensing

(2016) Jinho Kim et al.   ANALYTICAL CHEMISTRY

Multicolor Fluorescence Detection-Based Microfluidic Device for Single-Cell Metabolomics: Simultaneous Quantitation of Multiple Small Molecules in Primary Liver Cells

(2016) Qingling Li et al.   ANALYTICAL CHEMISTRY

Integrated microfluidic aptasensor for mass spectrometric detection of vasopressin in human plasma ultrafiltrate

(2016) J. Yang et al.   Analytical Methods

High-Throughput Single-Cell Cultivation on Microfluidic Streak Plates

(2016) Cheng-Ying Jiang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A microfluidic multiwell chip for enzyme-free detection of mRNA from few cells

(2016) Michaela Haider et al.   BIOSENSORS & BIOELECTRONICS

Microfluidic techniques for high throughput single cell analysis

(2016) Amy Reece et al.   CURRENT OPINION IN BIOTECHNOLOGY

A competitive luminol chemiluminescence immunosensor based on a microfluidic chip for the determination of ractopamine

(2016) Sai Wang et al.   ELECTROPHORESIS

Picomolar detection of carcinoembryonic antigen in whole blood using microfluidics and surface-enhanced Raman spectroscopy

(2016) Kun Zou et al.   ELECTROPHORESIS

Monitoring of chromosome dynamics of single yeast cells in a microfluidic platform with aperture cell traps

(2016) Si Hyung Jin et al.   LAB ON A CHIP

Microfluidic co-culture platform to quantify chemotaxis of primary stem cells

(2016) Z. Tatárová et al.   LAB ON A CHIP

A microfluidic cell-trapping device for single-cell tracking of host–microbe interactions

(2016) Matthieu J. Delincé et al.   LAB ON A CHIP

One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

(2016) Hyungseok Lee et al.   LAB ON A CHIP

High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays

(2016) Nathan Cermak et al.   NATURE BIOTECHNOLOGY

Ultrahigh-throughput–directed enzyme evolution by absorbance-activated droplet sorting (AADS)

(2016) Fabrice Gielen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Microfluidic Systems Enabling High-Throughput Single-Cell Protein Characterization

(2016) Beiyuan Fan et al.   SENSORS

A microfluidic platform for trapping, releasing and super-resolution imaging of single cells

(2016) Ying Zhou et al.   SENSORS AND ACTUATORS B-CHEMICAL

In Situ Electrochemical ELISA for Specific Identification of Captured Cancer Cells

(2015) Tina Saberi Safaei et al.   ACS Applied Materials & Interfaces

Raman-Activated Cell Sorting Based on Dielectrophoretic Single-Cell Trap and Release

(2015) Peiran Zhang et al.   ANALYTICAL CHEMISTRY

A microfluidic device enabling high-efficiency single cell trapping

(2015) D. Jin et al.   Biomicrofluidics

Droplet-based microfluidics for high-throughput screening of a metagenomic library for isolation of microbial enzymes

(2015) Masahito Hosokawa et al.   BIOSENSORS & BIOELECTRONICS

Fabrication of a polystyrene microfluidic chip coupled to electrospray ionization mass spectrometry for protein analysis

(2015) Xianqiao Hu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A high-throughput drop microfluidic system for virus culture and analysis

(2015) Audrey E. Fischer et al.   JOURNAL OF VIROLOGICAL METHODS

Droplet-in-oil array for picoliter-scale analysis based on sequential inkjet printing

(2015) Yingnan Sun et al.   LAB ON A CHIP

Optical trapping and manipulation of micrometer and submicrometer particles

(2015) Mark Daly et al.   Laser & Photonics Reviews

Determination of the pseudoephedrine content in pharmaceutical formulations and in biological fluids using a microbore HPLC system interfaced to a microfluidic chemiluminescence detector

(2015) Afsal Mohammed Kadavilpparampu et al.   LUMINESCENCE

Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics

(2015) Majid Ebrahimi Warkiani et al.   Nature Protocols

Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast

(2015) Mingtao Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controllable microdroplet splitting via additional lateral flow and its application in rapid synthesis of multi-scale microspheres

(2015) Bingpu Zhou et al.   RSC Advances

Microfluidic 3D models of cancer

(2014) Kyung Eun Sung et al.   ADVANCED DRUG DELIVERY REVIEWS

Single-cell cloning and expansion of human induced pluripotent stem cells by a microfluidic culture device

(2014) Taku Matsumura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microfluidic perfusion culture system for multilayer artery tissue models

(2014) Yuka Yamagishi et al.   Biomicrofluidics

Single-cell trapping and selective treatment via co-flow within a microfluidic platform

(2014) A. Benavente-Babace et al.   BIOSENSORS & BIOELECTRONICS

Active microdroplet merging by hydrodynamic flow control using a pneumatic actuator-assisted pillar structure

(2014) Dong Hyun Yoon et al.   LAB ON A CHIP

A microfluidic platform for profiling biomechanical properties of bacteria

(2014) Xuanhao Sun et al.   LAB ON A CHIP

A high-efficiency microfluidic device for size-selective trapping and sorting

(2014) Jinho Kim et al.   LAB ON A CHIP

Sorting drops and cells with acoustics: acoustic microfluidic fluorescence-activated cell sorter

(2014) Lothar Schmid et al.   LAB ON A CHIP

Digital Optofluidics: LED-Gated Transport and Fusion of Microliter-Sized Organic Droplets for Chemical Synthesis

(2014) Anna Venancio-Marques et al.   LANGMUIR

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption

(2014) Benjamin L Wang et al.   NATURE BIOTECHNOLOGY

Analytical detection techniques for droplet microfluidics—A review

(2013) Ying Zhu et al.   ANALYTICA CHIMICA ACTA

Recent advances in the development of single cell analysis—A review

(2013) Karel Klepárník et al.   ANALYTICA CHIMICA ACTA

Microfluidic Amperometric Sensor for Analysis of Nitric Oxide in Whole Blood

(2013) Rebecca A. Hunter et al.   ANALYTICAL CHEMISTRY

A microfluidic chip for direct and rapid trapping of white blood cells from whole blood

(2013) Jingdong Chen et al.   Biomicrofluidics

A high-throughput screen for antibiotic drug discovery

(2013) Thomas C. Scanlon et al.   BIOTECHNOLOGY AND BIOENGINEERING

On-chip magnetic separation and encapsulation of cells in droplets

(2013) Aaron Chen et al.   LAB ON A CHIP

Surface acoustic waves for on-demand production of picoliter droplets and particle encapsulation

(2013) David J. Collins et al.   LAB ON A CHIP

High-throughput screening for industrial enzyme production hosts by droplet microfluidics

(2013) Staffan L. Sjostrom et al.   LAB ON A CHIP

Living cell manipulation in a microfluidic device by femtosecond optical tweezers

(2013) Yan Li et al.   OPTICS AND LASERS IN ENGINEERING

A microfluidic device for the hydrodynamic immobilisation of living fission yeast cells for super-resolution imaging

(2013) Laurence Bell et al.   SENSORS AND ACTUATORS B-CHEMICAL

Active and Precise Control of Microdroplet Division Using Horizontal Pneumatic Valves in Bifurcating Microchannel

(2013) Dong Yoon et al.   Micromachines

Hydrodynamic Cell Trapping for High Throughput Single-Cell Applications

(2013) Amin Banaeiyan et al.   Micromachines

Microdroplet coalescences at microchannel junctions with different collision angles

(2012) Kai Wang et al.   AICHE JOURNAL

Coalescences of microdroplets at a cross-shaped microchannel junction without strictly synchronism control

(2012) Kai Wang et al.   CHEMICAL ENGINEERING JOURNAL

Automated analysis of single stem cells in microfluidic traps

(2012) Stefan A. Kobel et al.   LAB ON A CHIP

Cell separation based on size and deformability using microfluidic funnel ratchets

(2012) Sarah M. McFaul et al.   LAB ON A CHIP

Rapid screening of antibiotic toxicity in an automated microdroplet system

(2012) Krzysztof Churski et al.   LAB ON A CHIP

Optofluidic differential spectroscopy for absorbance detection of sub-nanolitre liquid samples

(2012) Wuzhou Song et al.   LAB ON A CHIP

Microfluidic Western blotting

(2012) A. J. Hughes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Regulated, Droplet-Based Sample Chopper for Microfluidic Absorbance Detection

(2011) Kennon S. Deal et al.   ANALYTICAL CHEMISTRY

Particle manipulation in a microfluidic channel using acoustic trap

(2011) Jong Seob Jeong et al.   BIOMEDICAL MICRODEVICES

Fast on-demand droplet fusion using transient cavitation bubbles

(2011) Z. G. Li et al.   LAB ON A CHIP

High-speed droplet generation on demand driven by pulse laser-induced cavitation

(2011) Sung-Yong Park et al.   LAB ON A CHIP

A microfluidic-based hydrodynamic trap: design and implementation

(2011) Melikhan Tanyeri et al.   LAB ON A CHIP

A microdroplet dilutor for high-throughput screening

(2011) Xize Niu et al.   Nature Chemistry

Single-cell genomics

(2011) Tomer Kalisky et al.   NATURE METHODS

Automated Microfluidic Screening Assay Platform Based on DropLab

(2010) Wen-Bin Du et al.   ANALYTICAL CHEMISTRY

Real-Time Monitoring of RNA Synthesis in a Phospholipid-Coated Microdroplet as a Live-Cell Model

(2010) Akihiko Tsuji et al.   CHEMBIOCHEM

High-Throughput Screening of Enzymes by Retroviral Display Using Droplet-Based Microfluidics

(2010) Lucia Granieri et al.   CHEMISTRY & BIOLOGY

Chemical and biological single cell analysis

(2010) Andreas Schmid et al.   CURRENT OPINION IN BIOTECHNOLOGY

High-throughput sample introduction for droplet-based screening with an on-chip integrated sampling probe and slotted-vial array

(2010) Meng Sun et al.   LAB ON A CHIP

A microfluidic platform for complete mammalian cell culture

(2010) Irena Barbulovic-Nad et al.   LAB ON A CHIP

An efficient microfluidic sorter: implementation of double meandering micro striplines for magnetic particles switching

(2010) Tian Fook Kong et al.   Microfluidics and Nanofluidics

High-throughput injection with microfluidics using picoinjectors

(2010) A. R. Abate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell manipulation on microfluidic chip by dielectrophoretic actuation and impedance detection

(2010) Hyunjin Park et al.   SENSORS AND ACTUATORS B-CHEMICAL

Review of cell and particle trapping in microfluidic systems

(2009) J. Nilsson et al.   ANALYTICA CHIMICA ACTA

Dielectrophoresis for manipulation of micro/nano particles in microfluidic systems

(2009) C. Zhang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Microfluidics as a functional tool for cell mechanics

(2009) Siva A. Vanapalli et al.   Biomicrofluidics

On-chip electrocoalescence of microdroplets as a function of voltage, frequency and droplet size

(2009) Michele Zagnoni et al.   LAB ON A CHIP

Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity

(2009) Jean-Christophe Baret et al.   LAB ON A CHIP

Drop-based microfluidic devices for encapsulation of single cells

(2008) Sarah Köster et al.   LAB ON A CHIP

Microfluidic high-throughput encapsulation and hydrodynamic self-sorting of single cells

(2008) M. Chabert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene transfer and protein dynamics in stem cells using single cell electroporation in a microfluidic device

(2007) A. Valero et al.   LAB ON A CHIP

On-chip polymerase chain reaction microdevice employing a magnetic droplet-manipulation system

(2007) Hiroyoshi Tsuchiya et al.   SENSORS AND ACTUATORS B-CHEMICAL