Article
Biophysics
Aynur Abdulla, Zhianan Zhang, Khan Zara Ahmad, Antony R. Warden, Hengyu Li, Xianting Ding
Summary: This study demonstrates a novel antibody functionalized microfluidic chip that can rapidly and accurately capture circulating tumor cells (CTCs) from cancer patients' whole blood. The chip offers a valuable tool for cancer screening, prognosis, and diagnosis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Alan M. Gonzalez-Suarez, Gulnaz Stybayeva, William A. Carey, Alexander Revzin
Summary: We have developed a microfluidic device that enables rapid analysis of biomarkers in whole blood, providing high sensitivity and real-time monitoring. This device has applications in monitoring hypoglycemia and detecting other biomarkers in whole blood.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Nicolas Castano, Sungu Kim, Adrian M. Martin, Stephen J. Galli, Kari C. Nadeau, Sindy K. Y. Tang
Summary: In this study, an integrated basophil isolation device (i-BID) was developed using microfluidics for rapid and high-purity separation of basophils from 100 μL of whole blood. The device includes a magnetic separation module that effectively captures non-basophils while preventing clogging. The i-BID achieved an average purity of 93.9% +/- 3.6% and a recovery rate of 95.6% +/- 3.4%, without causing degradation or unintentional activation of basophils. This research has important implications for basophil-based diagnostics in allergic disorders and other diseases.
Article
Multidisciplinary Sciences
Zhenglin Li, Chao Liu, Yangchang Cheng, Yike Li, Jinqi Deng, Lixiao Bai, Lili Qin, Huili Mei, Min Zeng, Fei Tian, Shaohua Zhang, Jiashu Sun
Summary: Tumor-derived extracellular vesicles (EVs) have the potential to improve noninvasive early cancer diagnosis. However, the lack of effective methods for isolating and detecting nanosized EVs in blood samples has been a challenge. To address this, researchers designed cascaded microfluidic circuits to filter EVs using a pneumatic clock pulse generator. This device allows for rapid and high-purity isolation of EVs from blood within 30 minutes and has shown 91% accuracy in diagnosing early-stage breast cancer.
Article
Chemistry, Analytical
Shun Zhang, Jiuyi Chen, Dan Liu, Bei Hu, Guangcheng Luo, Zhen Huang
Summary: Direct RNA detection is achieved using a microfluidic RNA chip that offers high specificity, rapidity, and reusability. Disease-associated RNAs have been successfully detected in clinical samples, demonstrating the potential of this technology in biomedical research and clinical diagnosis.
Article
Nanoscience & Nanotechnology
Chenxi Zhao, Xiaoxia Jian, Xi Zhang, Junli Guo, Zhida Gao, Yan-Yan Song
Summary: This study introduces an innovative nanostructure for efficient capture and inactivation of target tumor cells, demonstrating high selectivity and cell-isolation efficiency in real blood samples. The nanostructure, equipped with accurate recognition probes, selectively captures target cells at low concentrations and has a high recovery rate, showcasing remarkable performance for isolating and killing target cells from a complex medium.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Zhaohe Wang, Yongqian Zhang, Zhe Li, Hao Wang, Nuomin Li, Yulin Deng
Summary: As an ideal in vitro model, brain-on-chip (BoC) is an important tool for understanding brain characteristics comprehensively. However, the definition scope of BoC in vitro models has not been universally recognized. In this review, BoC is divided into brain cells-on-a-chip, brain slices-on-a-chip, and brain organoids-on-a-chip based on the type of culture on the chip. Despite their different construction methods, these three microfluidic BoCs all use microfluidic chips as carrier tools, which can maintain high culture activity on a chip for a long time. Moreover, BoC has successfully integrated various technologies, enabling the chip to present structural diversity and high compatibility to meet different experimental needs and expand the scope of applications. This article summarizes the relevant core technologies, challenges, and future development trends of BoC.
Article
Chemistry, Analytical
Yanjuan Wang, Ning Tong, Fengqi Li, Kai Zhao, Deguang Wang, Yijie Niu, Fengqiang Xu, Jiale Cheng, Junsheng Wang
Summary: In this study, a microfluidic trapping system based on AC dielectrophoresis (DEP) technology was proposed for precise trapping and release of specific microparticles. Numerical simulation and experimental verification were conducted to confirm the effectiveness of the designed system, contributing to the application of cell trapping and manipulation, as well as single-cell analysis.
Article
Virology
Weide Su, Jingjiang Qiu, Ying Mei, Xian-En Zhang, Yong He, Feng Li
Summary: Virus identification is crucial for early diagnosis and prevention of epidemics. A microfluidic chip can be used for virus cultivation and host-cell screening, providing a fast and efficient method to identify emerging viruses.
Article
Biochemical Research Methods
Qinan Ban, Yulong Zhang, Yuxuan Li, Daye Cao, Weifeng Ye, Linsheng Zhan, Daming Wang, Xiaohui Wang
Summary: This study developed a point-of-care microfluidic channel-based device for direct measurement of fibrinogen concentration in whole blood. Rapid diagnosis of fibrinogen concentration is of great importance in bleeding patients, and this device shows potential for assessing the suitability of fibrinogen replacement therapy.
Article
Engineering, Biomedical
Sumin Kim, Somin Lee, Jungeun Lim, Hyeri Choi, Habin Kang, Noo Li Jeon, Youngsook Son
Summary: The study established a human BBB microvasculature model and found that hBM-MSCs play a crucial role in tight BBB reformation, while astrocytes are important in inducing capillary network maturation.
Article
Engineering, Electrical & Electronic
Malihe Farasat, Seyede Maede Chavoshi, Atin Bakhshi, Aref Valipour, Majid Badieirostami
Summary: Circulating tumor cells (CTCs) serve as valuable biomarkers for early cancer diagnosis, and this article presents a novel method utilizing dielectrophoresis and a microfluidic chip to trap and analyze CTCs efficiently.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Chemistry, Applied
Mantong Zhao, Xiaolong Li, Yule Zhang, Yuwen Wang, Bo Wang, Lulu Zheng, Dawei Zhang, Songlin Zhuang
Summary: An automated microfluidics system was developed for the detection of chloramphenicol (CAP) residues in milk, which had high reliability, low cost, a good detection limit, and recovery rate. This system showed significant potential for point-of-care testing (POCT) of CAP in milk.
Article
Chemistry, Multidisciplinary
Gaowa Xing, Weifei Zhang, Nan Li, Qiaosheng Pu, Jin-Ming Lin
Summary: This article discusses the advances in bacteria detection using microfluidic biosensors. It introduces typical methods for pathogenic bacteria capture, separation, and detection, as well as key applications of microfluidic biosensor-based rapid bacteria detection. Furthermore, it concludes and discusses possible research prospects in the field of microfluidic biosensors for the rapid detection of pathogenic bacteria.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Zaidon T. Al-aqbi, Salim Albukhaty, Ameerah M. Zarzoor, Ghassan M. Sulaiman, Khalil A. A. Khalil, Tareg Belali, Mohamed T. A. Soliman
Summary: A novel microfluidic device featuring a nano-junction was developed for on-chip filtration and out-chip collection of blood plasma with a high extraction yield; the device effectively removes blood cells and plasma proteins, allowing for the detection of analytes at low concentrations.
Article
Biochemical Research Methods
Cong Wang, Shikun Zhao, Xianglong Zhao, Luan Chen, Zhengan Tian, Xiang Chen, Shengying Qin
Article
Biophysics
Shujing Lin, Xiao Zhi, Di Chen, Fangfang Xia, Yihuan Shen, Jiaqi Niu, Shiyi Huang, Jie Song, Jianmin Miao, Daxiang Cui, Xianting Ding
BIOSENSORS & BIOELECTRONICS
(2019)
Review
Chemistry, Multidisciplinary
Shujing Lin, Zixian Yu, Di Chen, Zhigang Wang, Jianmin Miao, Qichao Li, Daoyuan Zhang, Jie Song, Daxiang Cui
Article
Nanoscience & Nanotechnology
Qichao Li, Di Chen, Jianmin Miao, Shujing Lin, Zixian Yu, Yutong Han, Zhi Yang, Xiao Zhi, Daxiang Cui, Zhenghua An
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Optics
Jingdong Chen, Yating Song, Tingting Zhang, Wenjie Wang, Shaoding Liu
OPTICS COMMUNICATIONS
(2020)
Article
Chemistry, Analytical
Qichao Li, Di Chen, Jianmin Miao, Shujing Lin, Zixian Yu, Daxiang Cui, Zhi Yang, Xianping Chen
Summary: A high-performance gas sensor based on ordered porous ZnO nanosheets with fast response and high sensitivity for ethanol detection applications is presented in this study.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Electrical & Electronic
Qichao Li, Yamin Liu, Di Chen, Jianmin Miao, Shujing Lin, Daxiang Cui
Summary: Flexible piezoresistive sensors are prepared using L-cystine and aerogel, showing good linearity and great potential for applications in electronic skin.
IEEE ELECTRON DEVICE LETTERS
(2021)
Article
Chemistry, Analytical
Yanmin Wang, Wanlei Gao, Man Wu, Xiaofen Zhang, Wei Liu, Yang Zhou, Chunping Jia, Hui Cong, Xiang Chen, Jianlong Zhao
Summary: A multifunctional microfluidic chip was developed for the capture, lysis and nucleic acid detection of CTCs, successfully detecting gene mutations in lung cancer cells.
Article
Nanoscience & Nanotechnology
Jie Wang, Yang Li, Rui Wang, Chao Han, Shiquan Xu, Tingting You, Yuhuan Li, Junjie Xia, Xing Xu, Dongmei Wang, Huamei Tang, Chaoyong Yang, Xiang Chen, Zhihai Peng
Summary: The study developed an efficient CTC detection system by integrating different technologies, successfully achieving the capture and identification of CTCs with high application potential.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Qichao Li, Yamin Liu, Di Chen, Jianmin Miao, Xiao Zhi, Shengwei Deng, Shujing Lin, Han Jin, Daxiang Cui
Summary: Silver doping significantly impacts the sensing properties of graphene-based sensors, with silver-doped graphene showing the highest sensitivity to NO2, which enhances the gas sensor's ability to track NO2 effectively.
Article
Biophysics
Zixian Yu, Shujing Lin, Fangfang Xia, Yanlei Liu, Di Zhang, Fei Wang, Yanpu Wang, Qichao Li, Jiaqi Niu, Chengxi Cao, Daxiang Cui, Nengquan Sheng, Jiazi Ren, Zhigang Wang, Di Chen
Summary: The ExoSD chip is a highly integrated platform for exosome separation and detection, capable of efficiently separating and detecting gastric cancer cell-derived exosomes with high recovery and purity.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Electrical & Electronic
Shujing Lin, Di Zhang, Yanpu Wang, Zixian Yu, Qichao Li, Fei Wang, Yuanchao Li, Yiping Guo, Jianmin Miao, Daxiang Cui, Di Chen
Summary: This study presents a cost-effective and solderable fabrication process for manufacturing stretchable circuit boards, demonstrating their excellent solderability. The feasibility of these circuit boards for wearable embedded systems is shown through the development of soft wireless pressure monitoring prototypes and soft posture detection and control systems. Tests reveal that the circuit boards and embedded systems are robust enough for application in wearable systems.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Nanoscience & Nanotechnology
Qichao Li, Yamin Liu, Di Chen, Jianmin Miao, Chunlei Zhang, Daxiang Cui
Summary: In this study, wearable strain sensors with good sensitivity, stretchability, softness, durability, and biocompatibility were prepared using soft silicone elastomer and carbon nanotubes. The sensors exhibited high sensitivity and a large sensing strain range, as well as strong robustness and biocompatibility.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemical Research Methods
Fei Wang, Shujing Lin, Zixian Yu, Yanpu Wang, Di Zhang, Chengxi Cao, Zhigang Wang, Daxiang Cui, Di Chen
Summary: This review discusses the applications of electroporation in biotechnology, providing an overview of its mechanism, principles, and detection methods. It also presents the recent advances in microfluidic-based electroporation devices and discusses the challenges and outlook for cell membrane electroporation.
Article
Optics
Tingting Zhang, Zhuonan Jia, Zhenghua Li, Shuangquan Hua, Jingdong Chen, Wenjie Wang, Shaoding Liu
OPTICS COMMUNICATIONS
(2020)