Elucidating the Impact of CHO Cell Culture Media on Tryptophan Oxidation of a Monoclonal Antibody Through Gene Expression Analyses

Thiol-based copper handling by the copper chaperone Atox1

(2017) Yuta Hatori et al.   IUBMB LIFE

Transcriptomic changes in CHO cells after adaptation to suspension growth in protein-free medium analysed by a species-specific microarray

(2017) Smriti Shridhar et al.   JOURNAL OF BIOTECHNOLOGY

The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats

(2016) Courtney J. Mercadante et al.   BIOMETALS

S-Sulfocysteine simplifies fed-batch processes and increases the CHO specific productivity via anti-oxidant activity

(2016) Caroline Hecklau et al.   JOURNAL OF BIOTECHNOLOGY

Untargeted Metabolomics Analysis Reveals a Link between ETHE1-Mediated Disruptive Redox State and Altered Metabolic Regulation

(2016) Navid Sahebekhtiari et al.   JOURNAL OF PROTEOME RESEARCH

Antibodies to watch in 2017

(2016) Janice M. Reichert   mAbs

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture

(2016) Andrea Bedoya-López et al.   PLoS One

Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

(2016) Amanda M. Lewis et al.   PLoS One

Global insights into the Chinese hamster and CHO cell transcriptomes

(2015) Nandita Vishwanathan et al.   BIOTECHNOLOGY AND BIOENGINEERING

A global RNA-seq-driven analysis of CHO host and production cell lines reveals distinct differential expression patterns of genes contributing to recombinant antibody glycosylation

(2015) Jennifer D. Könitzer et al.   Biotechnology Journal

Chemically defined media modifications to lower tryptophan oxidation of biopharmaceuticals

(2015) Laurie B. Hazeltine et al.   BIOTECHNOLOGY PROGRESS

Structure of the α-crystallin domain from the redox-sensitive chaperone, HSPB1

(2015) Ponni Rajagopal et al.   JOURNAL OF BIOMOLECULAR NMR

Transcriptome analysis of a CHO cell line expressing a recombinant therapeutic protein treated with inducers of protein expression

(2015) Dina Fomina-Yadlin et al.   JOURNAL OF BIOTECHNOLOGY

Persulfides: current knowledge and challenges in chemistry and chemical biology

(2015) Chung-Min Park et al.   Molecular BioSystems

A global RNA-seq-driven analysis of CHO host and production cell lines reveals distinct differential expression patterns of genes contributing to recombinant antibody glycosylation

(2015) Jennifer D. Könitzer et al.   Biotechnology Journal

Effects of copper on CHO cells: Insights from gene expression analyses

(2014) Inn H. Yuk et al.   BIOTECHNOLOGY PROGRESS

A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies

(2014) Jan Stracke et al.   mAbs

Gene Ontology Consortium: going forward

(2014)   NUCLEIC ACIDS RESEARCH

The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

(2013) Helene Faustrup Kildegaard et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Role of Metallothionein in Oxidative Stress

(2013) Branislav Ruttkay-Nedecky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome

(2013) Nathan E Lewis et al.   NATURE BIOTECHNOLOGY

Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

(2013) Riccardo Torosantucci et al.   PHARMACEUTICAL RESEARCH

Thrombospondin-1 Regulates Blood Flow via CD47 Receptor–Mediated Activation of NADPH Oxidase 1

(2012) Gábor Csányi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase

(2012) Yi Sun et al.   Protein & Cell

Chinese hamster genome database: An online resource for the CHO community at www.CHOgenome.org

(2011) Stephanie Hammond et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells

(2011) Yueming Qian et al.   BIOTECHNOLOGY PROGRESS

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

Fast and SNP-tolerant detection of complex variants and splicing in short reads

(2010) T. D. Wu et al.   BIOINFORMATICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Modulation of Redox Switches of Copper Chaperone Cox17 by Zn(II) Ions Determined by New ESI MS-Based Approach

(2008) Kairit Zovo et al.   ANTIOXIDANTS & REDOX SIGNALING

Post-translational Modifications of Recombinant Proteins: Significance for Biopharmaceuticals

(2008) Nigel Jenkins et al.   MOLECULAR BIOTECHNOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH