Chemically defined media modifications to lower tryptophan oxidation of biopharmaceuticals

Benchmarking of commercially available CHO cell culture media for antibody production

(2015) David Reinhart et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cell culture media supplementation of bioflavonoids for the targeted reduction of acidic species charge variants on recombinant therapeutic proteins

(2015) Patrick Hossler et al.   BIOTECHNOLOGY PROGRESS

Optimization of chemically defined feed media for monoclonal antibody production in Chinese hamster ovary cells

(2015) Shohei Kishishita et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture

(2015) Shohei Kishishita et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid

(2014) Melissa Mun et al.   BIOTECHNOLOGY AND BIOENGINEERING

Control of galactosylated glycoforms distribution in cell culture system

(2014) Neil A. McCracken et al.   BIOTECHNOLOGY PROGRESS

Manganese increases high mannose glycoform on monoclonal antibody expressed in CHO when glucose is absent or limiting: Implications for use of alternate sugars

(2014) Tanaya Surve et al.   BIOTECHNOLOGY PROGRESS

Effects of copper on CHO cells: Insights from gene expression analyses

(2014) Inn H. Yuk et al.   BIOTECHNOLOGY PROGRESS

A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies

(2014) Jan Stracke et al.   mAbs

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

Iron and Copper in Mitochondrial Diseases

(2013) Wenjing Xu et al.   Cell Metabolism

Structural Characterization of New Microcystins Containing Tryptophan and Oxidized Tryptophan Residues

(2013) Jonathan Puddick et al.   Marine Drugs

Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

(2013) Riccardo Torosantucci et al.   PHARMACEUTICAL RESEARCH

Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media

(2012) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins

(2012) Miranda M. C. van Beers et al.   Biotechnology Journal

Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies

(2012) Yi Du et al.   mAbs

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

(2011) Michael J. Gramer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform

(2011) Efren Pacis et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS

(2011) Miriam Hensel et al.   PLoS One

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

Identification of cell culture conditions to controlN-glycosylation site-occupancy of recombinant glycoproteins expressed in CHO cells

(2009) Martin Gawlitzek et al.   BIOTECHNOLOGY AND BIOENGINEERING

The effect of low intensity ultraviolet-C light on monoclonal antibodies

(2009) Christopher M. Lorenz et al.   BIOTECHNOLOGY PROGRESS

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization

(2009) Junyan A. Ji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Post-translational Modifications of Recombinant Proteins: Significance for Biopharmaceuticals

(2008) Nigel Jenkins et al.   MOLECULAR BIOTECHNOLOGY

Heterogeneity of Monoclonal Antibodies

(2007) Hongcheng Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES