PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors: Figure 1.

Directing T cell differentiation and function with small molecule inhibitors

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Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

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Runx proteins regulate Foxp3 expression

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c-Rel is required for the development of thymic Foxp3+CD4 regulatory T cells

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Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells

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The UCSC Genome Browser database: update 2010

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DNA methylation controls Foxp3 gene expression

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The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease

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The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

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Dicer-dependent microRNA pathway safeguards regulatory T cell function

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Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

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T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

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A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

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