Acid sphingomyelinase mediates human CD4+ T-cell signaling: potential roles in T-cell responses and diseases

Types A and B Niemann-Pick disease

(2017) Edward H. Schuchman et al.   MOLECULAR GENETICS AND METABOLISM

Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development

(2016) Yuetao Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Autoimmune regulator and self-tolerance - molecular and clinical aspects

(2016) Jakub Abramson et al.   IMMUNOLOGICAL REVIEWS

A Functionalized Sphingolipid Analogue for Studying Redistribution during Activation in Living T Cells

(2016) Lena Collenburg et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+Conventional versus Foxp3+Regulatory T Cells

(2016) Claudia Hollmann et al.   JOURNAL OF IMMUNOLOGY

Host sphingomyelin increases West Nile virus infection in vivo

(2016) Miguel A. Martín-Acebes et al.   JOURNAL OF LIPID RESEARCH

Regulation of sphingomyelin metabolism

(2016) Kamil Bienias et al.   Pharmacological Reports

Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression

(2016) Emily R. Mercadante et al.   Frontiers in Immunology

Sphingomyelin breakdown in T cells: role in activation, effector functions and immunoregulation

(2015) Niklas Beyersdorf et al.   BIOLOGICAL CHEMISTRY

Effector T cell differentiation: are master regulators of effector T cells still the masters?

(2015) Chao Wang et al.   CURRENT OPINION IN IMMUNOLOGY

An Overview of Organ-Specific Autoimmune Diseases Including Immunotherapy

(2015) Lucy D. Mastrandrea   IMMUNOLOGICAL INVESTIGATIONS

T cells in the control of organ-specific autoimmunity

(2015) Jeffrey A. Bluestone et al.   JOURNAL OF CLINICAL INVESTIGATION

Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis

(2015) Huiming Peng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Beyond ecto-nucleotidase: CD39 defines human Th17 cells with CD161

(2015) Aiping Bai et al.   Purinergic Signalling

Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis

(2015) M Taniguchi et al.   Cell Death & Disease

Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses

(2015) A Bai et al.   Cell Death & Disease

NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine

(2015) Aiping Bai et al.   Nature Communications

Antigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune Diseases

(2015) Christine Riedhammer et al.   Frontiers in Immunology

Th17 cells in autoimmune diseases

(2015) Lei Han et al.   Frontiers of Medicine

CD39 and CD161 Modulate Th17 Responses in Crohn's Disease

(2014) Aiping Bai et al.   JOURNAL OF IMMUNOLOGY

Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages

(2013) Junfei Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transcriptional control of regulatory T cell development and function

(2013) Chong T. Luo et al.   TRENDS IN IMMUNOLOGY

Th17 Cells

(2012) Mohan S. Maddur et al.   AMERICAN JOURNAL OF PATHOLOGY

New insights of T cells in the pathogenesis of psoriasis

(2012) Yihua Cai et al.   Cellular & Molecular Immunology

Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release

(2012) Jean-Philip Truman et al.   IMMUNOLOGY

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

Different features of lung involvement in Niemann-Pick disease and Gaucher disease

(2012) Bora Gülhan et al.   RESPIRATORY MEDICINE

T cell-driven initiation and propagation of autoimmune diabetes

(2011) Maria Bettini et al.   CURRENT OPINION IN IMMUNOLOGY

C6-ceramide enhances Interleukin-12-mediated T helper type 1 cell responses through a cyclooxygenase-2-dependent pathway

(2011) Chin Siang Kue et al.   IMMUNOBIOLOGY

Regulation of NF-κB induction by TCR/CD28

(2011) Jing Cheng et al.   IMMUNOLOGIC RESEARCH

Ceramides as modulators of cellular and whole-body metabolism

(2011) Benjamin T. Bikman et al.   JOURNAL OF CLINICAL INVESTIGATION

Acid Sphingomyelinase Is Required for Protection of Effector Memory T Cells against Glucocorticoid-Induced Cell Death

(2011) D. Tischner et al.   JOURNAL OF IMMUNOLOGY

Cellular and Molecular Mechanisms of Autoimmune Disease

(2011) Brad Bolon   TOXICOLOGIC PATHOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Acid sphingomyelinase deficiency does not protect from graft-versus-host disease in transplant recipients with Niemann-Pick disease

(2010) J. Tolar et al.   BLOOD

The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation

(2010) Y.H. Zeidan et al.   CURRENT MOLECULAR MEDICINE

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

(2010) Jonathan D. Powell et al.   IMMUNITY

Studies on the Role of Acid Sphingomyelinase and Ceramide in the Regulation of Tumor Necrosis Factor α (TNFα)-converting Enzyme Activity and TNFα Secretion in Macrophages

(2010) Krasimira A. Rozenova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative regulatory events and Foxp3 expression

(2010) Masahide Tone et al.   NATURE IMMUNOLOGY

Defective Acid Sphingomyelinase Pathway withPseudomonas aeruginosaInfection in Cystic Fibrosis

(2009) Hong Yu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Activation of Membrane NADPH Oxidase Associated with Lysosome-Targeted Acid Sphingomyelinase in Coronary Endothelial Cells

(2009) Jun-Xiang Bao et al.   ANTIOXIDANTS & REDOX SIGNALING

Acid sphingomyelinase, cell membranes and human disease: Lessons from Niemann-Pick disease

(2009) Edward H. Schuchman   FEBS LETTERS

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes

(2009) Jasmin Herz et al.   NATURE IMMUNOLOGY

Improved Pulmonary Function by Acid Sphingomyelinase Inhibition in a Newborn Piglet Lavage Model

(2008) Philipp von Bismarck et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ceramide-enriched membrane domains—Structure and function

(2008) Yang Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases

(2008) Eric L. Smith et al.   FASEB JOURNAL

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology