Topoisomerases as anticancer targets

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

(2017) Ying-Ren Wang et al.   NUCLEIC ACIDS RESEARCH

Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase

(2017) Pan F. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

Multicenter Investigation of Gepotidacin (GSK2140944) Agar Dilution Quality Control Determinations for Neisseria gonorrhoeae ATCC 49226

(2016) Ronald N. Jones et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pathways of cardiac toxicity: comparison between chemotherapeutic drugs doxorubicin and mitoxantrone

(2016) Roberto Marques Damiani et al.   ARCHIVES OF TOXICOLOGY

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases

(2016) Timothy J. Miles et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors

(2016) Shivaani Kummar et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription

(2016) Laura Baranello et al.   CELL

Destruction of vasculogenic mimicry channels by targeting epirubicin plus celecoxib liposomes in treatment of brain glioma

(2016) Wan-Liang Lu et al.   International Journal of Nanomedicine

Review on the binding of anticancer drug doxorubicin with DNA and tRNA: Structural models and antitumor activity

(2016) D. Agudelo et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

(2016) Yves Pommier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes fromMycobacterium tuberculosis

(2016) Tim R. Blower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the active site of theStreptococcus pneumoniaetopoisomerase IV–DNA cleavage complex with novel 7,8-bridged fluoroquinolones

(2016) Ivan Laponogov et al.   Open Biology

Structure of a quinolone-stabilized cleavage complex of topoisomerase IV fromKlebsiella pneumoniaeand comparison with a relatedStreptococcus pneumoniaecomplex

(2016) Dennis A. Veselkov et al.   Acta Crystallographica Section D-Structural Biology

Mechanisms of drug resistance: quinolone resistance

(2015) David C. Hooper et al.   Annals of the New York Academy of Sciences

Interfacial inhibitors

(2015) Yves Pommier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mitoxantrone, More than Just Another Topoisomerase II Poison

(2015) Benny J. Evison et al.   MEDICINAL RESEARCH REVIEWS

Chemical profiling of the genome with anti-cancer drugs defines target specificities

(2015) Baoxu Pang et al.   Nature Chemical Biology

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration

(2015) Salim Khiati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin

(2015) Pan F. Chan et al.   Nature Communications

An overview of doxorubicin formulations in cancer therapy

(2015) Sangeeta Rivankar   Journal of Cancer Research and Therapeutics

Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U-Shaped Binding Mode

(2014) Jun Lu et al.   ACS Chemical Biology

Topoisomerase II and leukemia

(2014) MaryJean Pendleton et al.   Annals of the New York Academy of Sciences

HighIn VitroActivity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a New Effective Option for Oral Treatment of Gonorrhea

(2014) Susanne Jacobsson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroAntibacterial Activity of AZD0914, a New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria

(2014) Michael D. Huband et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of the Novel DNA Gyrase Inhibitor AZD0914: Low Resistance Potential and Lack of Cross-Resistance in Neisseria gonorrhoeae

(2014) Richard A. Alm et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Quinolone Action and Resistance

(2014) Katie J. Aldred et al.   BIOCHEMISTRY

Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both Topoisomerase II isoforms

(2014) Shiwei Deng et al.   BMC CANCER

Pegylated liposomal doxorubicin in the management of ovarian cancer

(2014) Nicoletta Staropoli et al.   CANCER BIOLOGY & THERAPY

Novel compounds targeting bacterial DNA topoisomerase/DNA gyrase

(2014) David E Ehmann et al.   CURRENT OPINION IN PHARMACOLOGY

The current role of mitoxantrone in the treatment of multiple sclerosis

(2014) Eleonora Cocco et al.   Expert Review of Neurotherapeutics

Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein

(2014) S. M. Vos et al.   GENES & DEVELOPMENT

Determination of Disk Diffusion and MIC Quality Control Guidelines for GSK2140944, a Novel Bacterial Type II Topoisomerase Inhibitor Antimicrobial Agent

(2014) J. E. Ross et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight into the Mechanism of Inhibition

(2014) Stephen J. Hearnshaw et al.   JOURNAL OF MOLECULAR BIOLOGY

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases II  and II  in vertebrate mitochondria

(2014) H. Zhang et al.   NUCLEIC ACIDS RESEARCH

Dexrazoxane for the treatment of chemotherapy-related side effects

(2014) Seppo Langer   Cancer Management and Research

Acute myeloid leukemia: 2013 update on risk-stratification and management

(2013) Elihu H. Estey   AMERICAN JOURNAL OF HEMATOLOGY

New Mechanistic and Functional Insights into DNA Topoisomerases

(2013) Stefanie Hartman Chen et al.   Annual Review of Biochemistry

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

(2013) Timothy J. Miles et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p

(2013) S. Solier et al.   CANCER RESEARCH

Non-quinolone Inhibitors of Bacterial Type IIA Topoisomerases: A Feat of Bioisosterism

(2013) Claudine Mayer et al.   CHEMICAL REVIEWS

New Strategies in the Treatment of Multiple Myeloma

(2013) N. C. Munshi et al.   CLINICAL CANCER RESEARCH

Topoisomerases facilitate transcription of long genes linked to autism

(2013) Ian F. King et al.   NATURE

Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I

(2013) Stefan Sobek et al.   NUCLEIC ACIDS RESEARCH

Structure of an ‘open’ clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport

(2013) Ivan Laponogov et al.   NUCLEIC ACIDS RESEARCH

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

(2013) Chyuan-Chuan Wu et al.   NUCLEIC ACIDS RESEARCH

Catalytic Inhibitors of Topoisomerase II Differently Modulate the Toxicity of Anthracyclines in Cardiac and Cancer Cells

(2013) Anna Vavrova et al.   PLoS One

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

(2013) Baoxu Pang et al.   Nature Communications

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy

(2012) Christian Bailly   CHEMICAL REVIEWS

High-Dimensional Descriptor Selection and Computational QSAR Modeling for Antitumor Activity of ARC-111 Analogues Based on Support Vector Regression (SVR)

(2012) Wei Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage

(2012) Timothy J. Wendorff et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of Human Topoisomerases I and II by Simocyclinone D8

(2012) Lisa M. Oppegard et al.   JOURNAL OF NATURAL PRODUCTS

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activity

(2012) Bryan H Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance

(2012) Jun Tao et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

(2012) Céline Douarre et al.   PLoS One

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives

(2011) Frédéric Collin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases

(2011) Timothy J. Miles et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases

(2011) Timothy J. Miles et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genz-644282, a Novel Non-Camptothecin Topoisomerase I Inhibitor for Cancer Treatment

(2011) L. S. Kurtzberg et al.   CLINICAL CANCER RESEARCH

Structure of QnrB1, a Plasmid-mediated Fluoroquinolone Resistance Factor

(2011) Matthew W. Vetting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression

(2011) Mahesh Ramamoorthy et al.   NUCLEIC ACIDS RESEARCH

Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV

(2011) S. L. Pitts et al.   NUCLEIC ACIDS RESEARCH

Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium

(2011) Xiaoli Xiong et al.   NUCLEIC ACIDS RESEARCH

Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program

(2011) Peter J. Houghton et al.   PEDIATRIC BLOOD & CANCER

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

(2011) C.-C. Wu et al.   SCIENCE

Structural and Biochemical Analysis of the Pentapeptide Repeat ProteinEfsQnr, a Potent DNA Gyrase Inhibitor

(2010) Subray S. Hegde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cardiotoxicity of anthracycline agents for the treatment of cancer: Systematic review and meta-analysis of randomised controlled trials

(2010) Lesley A Smith et al.   BMC CANCER

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

(2010) Bryan H. Schmidt et al.   NATURE

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

(2010) Alexandre Wohlkonig et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

(2010) Ivan Laponogov et al.   PLoS One

Drosophila topo III  is required for the maintenance of mitochondrial genome and male germ-line stem cells

(2010) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping Simocyclinone D8 Interaction with DNA Gyrase: Evidence for a New Binding Site on GyrB

(2009) C. Sissi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from Streptomyces antibioticus

(2009) L. M. Oppegard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

(2009) Yves Pommier   CHEMICAL REVIEWS

Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II

(2009) Ahad A. Sadiq et al.   INVESTIGATIONAL NEW DRUGS

Cardiovascular Complications of Cancer Therapy

(2009) Edward T.H. Yeh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives

(2009) Y. Pommier et al.   MOLECULAR CANCER THERAPEUTICS

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

(2009) Ivan Laponogov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel approach for organelle-specific DNA damage targeting reveals different susceptibility of mitochondrial DNA to the anticancer drugs camptothecin and topotecan

(2009) M. C. Díaz de la Loza et al.   NUCLEIC ACIDS RESEARCH

A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase

(2009) M. J. Edwards et al.   SCIENCE

Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

(2008) A. A. Miller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Action of the Antibiotic NXL101, a Novel Nonfluoroquinolone Inhibitor of Bacterial Type II Topoisomerases

(2008) M. T. Black et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial Topoisomerase I Sites in the Regulatory D-Loop Region of Mitochondrial DNA†

(2008) Hongliang Zhang et al.   BIOCHEMISTRY

Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis

(2008) S. K. Hasan et al.   BLOOD

Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells

(2008) Christine Radanyi et al.   CANCER LETTERS

Cardiotoxicity of Antitumor Drugs†

(2008) Pierantonio Menna et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Plk1-dependent Phosphorylation Regulates Functions of DNA Topoisomerase IIα in Cell Cycle Progression

(2008) Hongchang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Novobiocin Analogues That Manifest Anti-proliferative Activity against Several Cancer Cell Lines

(2008) Joseph A. Burlison et al.   JOURNAL OF ORGANIC CHEMISTRY

Bone marrow and tumor cell colony-forming units and human tumor xenograft efficacy of noncamptothecin and camptothecin topoisomerase I inhibitors

(2008) Leslie S. Kurtzberg et al.   MOLECULAR CANCER THERAPEUTICS

YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase

(2008) Sugopa Sengupta et al.   NUCLEIC ACIDS RESEARCH

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH

Next generation topoisomerase I inhibitors: Rationale and biomarker strategies

(2007) Beverly A. Teicher   BIOCHEMICAL PHARMACOLOGY