Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

Interactions between the Etoposide Derivative F14512 and Human Type II Topoisomerases: Implications for the C4 Spermine Moiety in Promoting Enzyme-Mediated DNA Cleavage

(2011) Amanda C. Gentry et al.   BIOCHEMISTRY

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

(2010) Bryan H. Schmidt et al.   NATURE

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

(2010) Michael C Haffner et al.   NATURE GENETICS

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

(2010) Alexandre Wohlkonig et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

(2010) Ivan Laponogov et al.   PLoS One

Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends

(2009) Brenno Neto et al.   MOLECULES

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

(2009) Ivan Laponogov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspective

(2009) T. R. L. Collins et al.   NUCLEIC ACIDS RESEARCH

Substituents on Etoposide That Interact with Human Topoisomerase IIα in the Binary Enzyme−Drug Complex: Contributions to Etoposide Binding and Activity†

(2008) Ryan P. Bender et al.   BIOCHEMISTRY

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH

DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

(2008) Allyn J. Schoeffler et al.   QUARTERLY REVIEWS OF BIOPHYSICS