Characterization of the Novel DNA Gyrase Inhibitor AZD0914: Low Resistance Potential and Lack of Cross-Resistance in Neisseria gonorrhoeae

HighIn VitroActivity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a New Effective Option for Oral Treatment of Gonorrhea

(2014) Susanne Jacobsson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroAntibacterial Activity of AZD0914, a New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria

(2014) Michael D. Huband et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial susceptibility/resistance and genetic characteristics of Neisseria gonorrhoeaeisolates from Poland, 2010-2012

(2014) Beata Mlynarczyk-Bonikowska et al.   BMC INFECTIOUS DISEASES

Russian gonococcal antimicrobial susceptibility programme (RU-GASP) – resistance in Neisseria gonorrhoeae during 2009–2012 and NG-MAST genotypes in 2011 and 2012

(2014) Anna Kubanova et al.   BMC INFECTIOUS DISEASES

Characterization of Neisseria gonorrhoeaeisolates detected in Switzerland (1998–2012): emergence of multidrug-resistant clones less susceptible to cephalosporins

(2014) Andrea Endimiani et al.   BMC INFECTIOUS DISEASES

Challenges with gonorrhea in the era of multi-drug and extensively drug resistance – are we on the right track?

(2014) Magnus Unemo et al.   Expert Review of Anti-Infective Therapy

High Prevalence of Ciprofloxacin-Resistant Gonorrhea Among Female Sex Workers in Kampala, Uganda (2008–2009)

(2014) Judith Vandepitte et al.   SEXUALLY TRANSMITTED DISEASES

Surveillance of Antimicrobial Susceptibilities of Neisseria gonorrhoeae in Nanning, China, 2000 to 2012

(2014) Bang-yong Zhu et al.   SEXUALLY TRANSMITTED DISEASES

Overcoming Target-Mediated Quinolone Resistance in Topoisomerase IV by Introducing Metal-Ion-Independent Drug–Enzyme Interactions

(2013) Katie J. Aldred et al.   ACS Chemical Biology

Antimicrobial Resistance and Molecular Typing of Neisseria gonorrhoeae Isolates in Kyoto and Osaka, Japan, 2010 to 2012: Intensified Surveillance after Identification of the First Strain (H041) with High-Level Ceftriaxone Resistance

(2013) Ken Shimuta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial susceptibilities and distribution of sequence types of Neisseria gonorrhoeae isolates in Canada: 2010

(2013) Irene Martin et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

(2013) Katie J. Aldred et al.   NUCLEIC ACIDS RESEARCH

Monitoring antimicrobial resistance inNeisseria gonorrhoeaein selected countries of the WHO South-East Asia Region between 2009 and 2012: a retrospective analysis

(2013) Manju Bala et al.   SEXUALLY TRANSMITTED INFECTIONS

Two decades of the gonococcal antimicrobial surveillance program in South America and the Caribbean: challenges and opportunities

(2013) Jo-Anne R Dillon et al.   SEXUALLY TRANSMITTED INFECTIONS

Trends in antimicrobial resistance inNeisseria gonorrhoeaein the USA: the Gonococcal Isolate Surveillance Project (GISP), January 2006–June 2012

(2013) Robert D Kirkcaldy et al.   SEXUALLY TRANSMITTED INFECTIONS

Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain

(2012) J. Camara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to Ceftriaxone

(2011) Makoto Ohnishi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

(2010) Ivan Laponogov et al.   PLoS One

Probing the Differential Interactions of Quinazolinedione PD 0305970 and Quinolones with Gyrase and Topoisomerase IV

(2009) X.-S. Pan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

(2008) A. A. Miller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY