☆ 4.7 Article

Multicenter Investigation of Gepotidacin (GSK2140944) Agar Dilution Quality Control Determinations for Neisseria gonorrhoeae ATCC 49226

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Volume 60, Issue 7, Pages 4404-4406

Publisher

AMER SOC MICROBIOLOGY

DOI: 10.1128/AAC.00527-16

Keywords

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Categories

Microbiology Pharmacology & Pharmacy

Funding

GlaxoSmithKline (GSK
Collegeville, PA, USA)
Office of the Assistant Secretary for Preparedness and Response, Biomedical Advanced Research and Development Authority [HHSO100201300011C]
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Abstract

Gepotidacin, a novel triazaacenaphthylene antibacterial agent, is the first in a new class of type IIA topoisomerase inhibitors with activity against many biothreat and conventional pathogens, including Neisseria gonorrhoeae. To assist ongoing clinical studies of gepotidacin to treat gonorrhea, a multilaboratory quality assurance investigation determined the reference organism (N. gonorrhoeae ATCC 49226) quality control MIC range to be 0.25 to 1 mu g/ml (88.8% of gepotidacin MIC results at the 0.5 mu g/ml mode).

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