Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation

Quantitative Proteomic Analysis of Differentially Expressed Protein Profiles Involved in Pancreatic Ductal Adenocarcinoma

(2016) Kung-Kai Kuo et al.   PANCREAS

‘Latent drivers’ expand the cancer mutational landscape

(2015) Ruth Nussinov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region

(2015) Hyunbum Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

(2015) Xiaolin Nan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

(2015) Frederick D. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTP-Dependent K-Ras Dimerization

(2015) Serena Muratcioglu et al.   STRUCTURE

The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression

(2015) Courtney Schaal et al.   Cancers

Contact inhibition against senescence

(2015) Peiqing Sun   Oncotarget

Dairy products and pancreatic cancer risk: a pooled analysis of 14 cohort studies

(2014) J. M. Genkinger et al.   ANNALS OF ONCOLOGY

Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame

(2014) Leanna R. Gentry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oligomerization and nanocluster organization render specificity

(2014) Ruth Nussinov et al.   BIOLOGICAL REVIEWS

Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist

(2014) Doo Li Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mutational profiles of different macroscopic subtypes of colorectal adenoma reveal distinct pathogenetic roles for KRAS, BRAF and PIK3CA

(2014) Li-Chun Chang et al.   BMC GASTROENTEROLOGY

Oncogenic KRAS signalling in pancreatic cancer

(2014) S Eser et al.   BRITISH JOURNAL OF CANCER

YAP1 Takes Over when Oncogenic K-Ras Slumbers

(2014) Florian R. Greten   CELL

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

(2014) Avnish Kapoor et al.   CELL

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Cancer signaling: when phosphorylation meets methylation

(2014) Haoqiang Ying et al.   CELL RESEARCH

RASSF tumor suppressor gene family: Biological functions and regulation

(2014) Natalia Volodko et al.   FEBS LETTERS

Structure of MST2 SARAH domain provides insights into its interaction with RAPL

(2014) Guoguang Liu et al.   JOURNAL OF STRUCTURAL BIOLOGY

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

(2014) Pawel K. Mazur et al.   NATURE

Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH

(2014) Jelena Urosevic et al.   NATURE CELL BIOLOGY

The free energy landscape in translational science: how can somatic mutations result in constitutive oncogenic activation?

(2014) Chung-Jung Tsai et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Ras Effector Mutant Expression Suggest a Negative Regulator Inhibits Lung Tumor Formation

(2014) Guillaume Vandal et al.   PLoS One

Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program

(2014) O. V. Leontieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic multiprotein assemblies shape the spatial structure of cell signaling

(2014) Ruth Nussinov et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence

(2014) Yingxi Xu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Spatial and temporal organization of signaling pathways

(2014) Benjamin E. Housden et al.   TRENDS IN BIOCHEMICAL SCIENCES

Serum calcium level used as a prognostic predictor in patients with resectable pancreatic ductal adenocarcinoma

(2014) Qian Dong et al.   Clinics and Research in Hepatology and Gastroenterology

A Unified View of “How Allostery Works”

(2014) Chung-Jung Tsai et al.   PLoS Computational Biology

Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway

(2014) Eunha Hwang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery

(2013) Ruth Nussinov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Tumor Cell Migration and Invasion Are Enhanced by Depletion of Rap1 GTPase-activating Protein (Rap1GAP)

(2013) Oxana M. Tsygankova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase A-dependent Phosphorylation of Rap1 Regulates Its Membrane Localization and Cell Migration

(2013) Maho Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Orai3 Constitutes a Native Store-Operated Calcium Entry That Regulates Non Small Cell Lung Adenocarcinoma Cell Proliferation

(2013) Anne-Sophie Ay et al.   PLoS One

Allosteric Conformational Barcodes Direct Signaling in the Cell

(2013) Ruth Nussinov et al.   STRUCTURE

‘Pathway drug cocktail’: targeting Ras signaling based on structural pathways

(2013) Ruth Nussinov et al.   TRENDS IN MOLECULAR MEDICINE

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice

(2012) Hoogeun Song et al.   EMBO JOURNAL

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

(2012) Anitha Suram et al.   EMBO JOURNAL

RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells

(2012) Xiaoyun Dong et al.   ENDOCRINE-RELATED CANCER

Colorectal cancer and RASSF family-A special emphasis on RASSF1A

(2012) Maria Sofia Fernandes et al.   INTERNATIONAL JOURNAL OF CANCER

The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+Responses

(2012) Inga Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma

(2012) Anna Djos et al.   Molecular Cancer

Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition

(2012) S Cagnol et al.   ONCOGENE

Organization, dynamics, and segregation of Ras nanoclusters in membrane domains

(2012) L. Janosi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting protein-protein interactions on a proteome scale by matching evolutionary and structural similarities at interfaces using PRISM

(2011) Nurcan Tuncbag et al.   Nature Protocols

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Both the C-Terminal Polylysine Region and the Farnesylation of K-RasB Are Important for Its Specific Interaction with Calmodulin

(2011) Ling-Jia Wu et al.   PLoS One

Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors

(2011) A. T. Sasaki et al.   Science Signaling

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulating Rap small G-proteins in time and space

(2011) Martijn Gloerich et al.   TRENDS IN CELL BIOLOGY

Multiple Cellular Proteins Modulate the Dynamics of K-ras Association with the Plasma Membrane

(2010) Pinkesh Bhagatji et al.   BIOPHYSICAL JOURNAL

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

Allostery and population shift in drug discovery

(2010) Gozde Kar et al.   CURRENT OPINION IN PHARMACOLOGY

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

(2010) Matthias Drosten et al.   EMBO JOURNAL

Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences

(2010) Undraga Schagdarsurengin et al.   Molecular Cancer

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

The Hypervariable Region of K-Ras4B Is Responsible for Its Specific Interactions with Calmodulin

(2009) Sherwin J. Abraham et al.   BIOCHEMISTRY

Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2

(2009) Gita Kumari et al.   EXPERIMENTAL CELL RESEARCH

Hippo Pathway-Dependent and -Independent Roles of RASSF6

(2009) M. Ikeda et al.   Science Signaling

Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells

(2008) M. G. Rondaij et al.   BLOOD

Thinking Outside the Box about Ras

(2008) John M. Kyriakis   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Essential Interacting Elements in K-Ras/Calmodulin Binding and Its Role in K-Ras Localization

(2008) Cristina Lopez-Alcalá et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RalGDS Couples Growth Factor Signaling to Akt Activation

(2008) Y. Hao et al.   MOLECULAR AND CELLULAR BIOLOGY

A bistable Rb–E2F switch underlies the restriction point

(2008) Guang Yao et al.   NATURE CELL BIOLOGY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The RSK family of kinases: emerging roles in cellular signalling

(2008) Rana Anjum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Growth and Tumor Suppressors NORE1A and RASSF1A Are Targets for Calpain-Mediated Proteolysis

(2008) Sergey Kuznetsov et al.   PLoS One