RASSF tumor suppressor gene family: Biological functions and regulation

Ubiquitin Ligases and Cell Cycle Control

(2013) Leonardo K. Teixeira et al.   Annual Review of Biochemistry

RASSF10 is epigenetically silenced and functions as a tumor suppressor in gastric cancer

(2013) Ziran Wei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal

(2013) Yoshitaka Michifuri et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors

(2013) Jovana Klajic et al.   BMC CANCER

Elevated Plasma Levels of Hypermethylated RASSF1A Gene Sequences in Pregnant Women with Intrahepatic Cholestasis

(2013) Ping Yi et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase

(2013) Takeshi Nakamura et al.   GENES TO CELLS

The RASSF6 Tumor Suppressor Protein Regulates Apoptosis and the Cell Cycle via MDM2 Protein and p53 Protein

(2013) Hiroaki Iwasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alveolar rhabdomyosarcoma–associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression

(2013) Lisa E.S. Crose et al.   JOURNAL OF CLINICAL INVESTIGATION

Epstein–Barr virus latent membrane protein 1 increases genomic instability through Egr-1-mediated up-regulation of activation-induced cytidine deaminase in B-cell lymphoma

(2013) Joo Hyun Kim et al.   LEUKEMIA & LYMPHOMA

RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer

(2013) Asuki Fukatsu et al.   LUNG CANCER

Intact expression status of RASSF1A in acute myeloid leukemia

(2013) Davood Zare-Abdollahi et al.   MEDICAL ONCOLOGY

RASSF2 hypermethylation is present and related to shorter survival in squamous cervical cancer

(2013) David Guerrero-Setas et al.   MODERN PATHOLOGY

Epigenetic silencing of RASSF1A deregulates cytoskeleton and promotes malignant behavior of adrenocortical carcinoma

(2013) Reju Korah et al.   Molecular Cancer

Mitotic Arrest by Tumor Suppressor RASSF1A Is Regulated via CHK1 Phosphorylation

(2013) Lingyan Jiang et al.   MOLECULAR CANCER RESEARCH

Silencing of RASSF3 by DNA Hypermethylation Is Associated with Tumorigenesis in Somatotroph Adenomas

(2013) Hu Peng et al.   PLoS One

RASSF6 Expression in Adipocytes Is Down-Regulated by Interaction with Macrophages

(2013) Yohei Sanada et al.   PLoS One

The Tumor Suppressor Gene, RASSF1A, Is Essential for Protection against Inflammation -Induced Injury

(2013) Marilyn Gordon et al.   PLoS One

RASSF1A: A potential novel therapeutic target against cardiac hypertrophy

(2013) Chenyang Duan et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The E3 ubiquitin ligase Itch regulates tumor suppressor protein RASSF5/NORE1 stability in an acetylation-dependent manner

(2013) R Suryaraja et al.   Cell Death & Disease

RASSF1A Suppresses Cell Migration through Inactivation of HDAC6 and Increase of Acetylated alpha-Tubulin

(2013) Hae-Yun Jung et al.   Cancer Research and Treatment

The Intronic Long Noncoding RNA ANRASSF1 Recruits PRC2 to the RASSF1A Promoter, Reducing the Expression of RASSF1A and Increasing Cell Proliferation

(2013) Felipe C. Beckedorff et al.   PLoS Genetics

DNA methylation presents distinct binding sites for human transcription factors

(2013) Shaohui Hu et al.   eLife

Tissue factor pathway inhibitor-2 may interact with nuclear protein RASSF1C

(2012) X. Chen et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

(2012) Qiaoyan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The RASSF3 Candidate Tumor Suppressor Induces Apoptosis and G1-S Cell-Cycle Arrest via p53

(2012) T. Kudo et al.   CANCER RESEARCH

Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice

(2012) Hoogeun Song et al.   EMBO JOURNAL

Correlation between BRAF mutation and promoter methylation of TIMP3, RARβ2 and RASSF1A in thyroid cancer

(2012) Mariana Brait et al.   Epigenetics

The cellular apoptosis susceptibility CAS/CSE1L gene protects ovarian cancer cells from death by suppressing RASSF1C

(2012) Annalisa Lorenzato et al.   FASEB JOURNAL

Methylation of RASSF1A gene promoter is regulated by p53 and DAXX

(2012) Hailong Zhang et al.   FASEB JOURNAL

The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma

(2012) Anna Djos et al.   Molecular Cancer

Reactivation of RASSF1A in Breast Cancer Cells by Curcumin

(2012) Liping Du et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Epigenetic down regulation of RASSF10 and its possible clinical implication in prostate carcinoma

(2012) Temuujin Dansranjavin et al.   PROSTATE

The tumor suppressor RASSF10 is upregulated upon contact inhibition and frequently epigenetically silenced in cancer

(2012) A M Richter et al.   Oncogenesis

Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCPligases in response to DNA damage

(2011) Xin Zhou et al.   BIOCHEMICAL JOURNAL

Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1Cin pancreatic endocrine tumors

(2011) Giorgio Malpeli et al.   BMC CANCER

MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1

(2011) Hui Wang et al.   CARCINOGENESIS

When RASSF1A RAN into tumor suppression: Ran GTPase is a RASSF1A effector involved in controlling microtubule organization

(2011) Ashraf Dallol et al.   CELL CYCLE

RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7

(2011) S Takahashi et al.   CELL DEATH AND DIFFERENTIATION

Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1

(2011) Deresa Lee et al.   EMBO REPORTS

MicroRNAs and epigenetics

(2011) Fumiaki Sato et al.   FEBS Journal

Cullin-4A·DNA Damage-binding Protein 1 E3 Ligase Complex Targets Tumor Suppressor RASSF1A for Degradation during Mitosis

(2011) Lingyan Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-associated Protein 1S (MAP1S) Bridges Autophagic Components with Microtubules and Mitochondria to Affect Autophagosomal Biogenesis and Degradation

(2011) Rui Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RASSF10 Promoter Hypermethylation Is Frequent in Malignant Melanoma of the Skin but Uncommon in Nevus Cell Nevi

(2011) Peter Helmbold et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tumor Suppressor RASSF1A Promoter: p53 Binding and Methylation

(2011) Yihao Tian et al.   PLoS One

A Novel Role of RASSF9 in Maintaining Epidermal Homeostasis

(2011) Chiou-Mei Lee et al.   PLoS One

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

(2011) Sunil K. Verma et al.   Protein & Cell

14-3-3 Mediated regulation of the tumor suppressor protein, RASSF1A

(2010) Haya Abu Ghazaleh et al.   APOPTOSIS

Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis

(2010) Asha Recino et al.   BIOCHEMICAL JOURNAL

Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis

(2010) Mark E Reeves et al.   BMC CANCER

High RASSF1A promoter methylation levels are predictive of poor prognosis in fine-needle aspirate washings of breast cancer lesions

(2010) Ana Teresa Martins et al.   BREAST CANCER RESEARCH AND TREATMENT

MicroRNA-602 regulating tumor suppressive gene RASSF1A is over-expressed in hepatitis B virus-infected liver and hepatocellular carcinoma

(2010) Lian Yang et al.   CANCER BIOLOGY & THERAPY

miR-373 Negatively Regulates Methyl-CpG-Binding Domain Protein 2 (MBD2) in Hilar Cholangiocarcinoma

(2010) Yongjun Chen et al.   DIGESTIVE DISEASES AND SCIENCES

Frequent epigenetic inactivation of RASSF10 in thyroid cancer

(2010) Undraga Schagdarsurengin et al.   Epigenetics

Deficiency of Rap1-Binding Protein RAPL Causes Lymphoproliferative Disorders through Mislocalization of p27kip1

(2010) Koko Katagiri et al.   IMMUNITY

Tumor Suppressor Ras Association Domain Family 5 (RASSF5/NORE1) Mediates Death Receptor Ligand-induced Apoptosis

(2010) Jikyoung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth and Tumor Suppressor NORE1A Is a Regulatory Node between Ras Signaling and Microtubule Nucleation

(2010) Christine Bee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice

(2010) Dominic P. Del Re et al.   JOURNAL OF CLINICAL INVESTIGATION

The Ras Effector RASSF2 Controls the PAR-4 Tumor Suppressor

(2010) Howard Donninger et al.   MOLECULAR AND CELLULAR BIOLOGY

Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences

(2010) Undraga Schagdarsurengin et al.   Molecular Cancer

Upregulation of DNA Methyltransferase-Mediated Gene Silencing, Anchorage-Independent Growth, and Migration of Colon Cancer Cells by Interleukin-6

(2010) E. Foran et al.   MOLECULAR CANCER RESEARCH

miRBase: integrating microRNA annotation and deep-sequencing data

(2010) A. Kozomara et al.   NUCLEIC ACIDS RESEARCH

Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis

(2010) V K Hill et al.   ONCOGENE

The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways

(2010) F E Lock et al.   ONCOGENE

Functional importance of RASSF1A microtubule localization and polymorphisms

(2010) M El-Kalla et al.   ONCOGENE

Methyl-CpG binding protein MBD2 is implicated in methylation-mediated suppression of miR-373 in hilar cholangiocarcinoma

(2010) Chen   ONCOLOGY REPORTS

Structural Characterization of the DAXX N-Terminal Helical Bundle Domain and Its Complex with Rassf1C

(2010) Eric Escobar-Cabrera et al.   STRUCTURE

Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity

(2009) Hoogeun Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The N-terminal RASSF family: a new group of Ras-association-domaincontaining proteins, with emerging links to cancer formation

(2009) Victoria Sherwood et al.   BIOCHEMICAL JOURNAL

Aurora A Regulates Prometaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity

(2009) S. J. Song et al.   CANCER RESEARCH

RASSF1A Mediates p21Cip1/Waf1-Dependent Cell Cycle Arrest and Senescence through Modulation of the Raf-MEK-ERK Pathway and Inhibition of Akt

(2009) S. Thaler et al.   CANCER RESEARCH

Aurora B-Mediated Phosphorylation of RASSF1A Maintains Proper Cytokinesis by Recruiting Syntaxin16 to the Midzone and Midbody

(2009) S. J. Song et al.   CANCER RESEARCH

Tumor Suppressor Ras-Association Domain Family 1 Isoform A Is a Novel Regulator of Cardiac Hypertrophy

(2009) Delvac Oceandy et al.   CIRCULATION

PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas

(2009) D. S.P. Tan et al.   CLINICAL CANCER RESEARCH

RAN GTPase Is a RASSF1A Effector Involved in Controlling Microtubule Organization

(2009) Ashraf Dallol et al.   CURRENT BIOLOGY

ATM Regulates a RASSF1A-Dependent DNA Damage Response

(2009) Garth Hamilton et al.   CURRENT BIOLOGY

Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2

(2009) Gita Kumari et al.   EXPERIMENTAL CELL RESEARCH

SKP2 and CKS1 Promote Degradation of Cell Cycle Regulators and Are Associated With Hepatocellular Carcinoma Prognosis

(2009) Diego F. Calvisi et al.   GASTROENTEROLOGY

Megaoesophagus inRassf1a-null mice

(2009) Louise van der Weyden et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias

(2009) Luke B Hesson et al.   Molecular Cancer

Epigenetic Silencing of the RASSF1A Tumor Suppressor Gene through HOXB3-Mediated Induction of DNMT3B Expression

(2009) Rajendra Kumar Palakurthy et al.   MOLECULAR CELL

Hippo Pathway-Dependent and -Independent Roles of RASSF6

(2009) M. Ikeda et al.   Science Signaling

NDR Kinase Is Activated by RASSF1A/MST1 in Response to Fas Receptor Stimulation and Promotes Apoptosis

(2008) Anton Vichalkovski et al.   CURRENT BIOLOGY

The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2–DAXX–HAUSP complex

(2008) Min Sup Song et al.   EMBO JOURNAL

The tumour suppressor RASSF1A is a novel substrate of PKC

(2008) Sunil K. Verma et al.   FEBS LETTERS

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Rassf Family of Tumor Suppressor Polypeptides

(2008) Joseph Avruch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of RASSF1A/MOAP-1 Association with Death Receptors

(2008) C. J. Foley et al.   MOLECULAR AND CELLULAR BIOLOGY

RASSF7 Is a Member of a New Family of RAS Association Domain–containing Proteins and Is Required for Completing Mitosis

(2008) Victoria Sherwood et al.   MOLECULAR BIOLOGY OF THE CELL

Combined BubR1 protein down-regulation andRASSF1Ahypermethylation in Wilms tumors with diverse cytogenetic changes

(2008) Masayuki Haruta et al.   MOLECULAR CARCINOGENESIS

Loss of Rassf1a cooperates with Apc Min to accelerate intestinal tumourigenesis

(2008) L van der Weyden et al.   ONCOGENE

The Growth and Tumor Suppressors NORE1A and RASSF1A Are Targets for Calpain-Mediated Proteolysis

(2008) Sergey Kuznetsov et al.   PLoS One