Oligomerization and nanocluster organization render specificity

Free Energy Diagrams for Protein Function

(2014) Ruth Nussinov et al.   CHEMISTRY & BIOLOGY

The Underappreciated Role of Allostery in the Cellular Network

(2013) Ruth Nussinov et al.   Annual Review of Biophysics

Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation

(2013) Dimitar B. Nikolov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery

(2013) Ruth Nussinov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated Signaling

(2013) Pieta K. Mattila et al.   IMMUNITY

Spatial Coupling of JNK Activation to the B Cell Antigen Receptor by Tyrosine-Phosphorylated Ezrin

(2013) N. Parameswaran et al.   JOURNAL OF IMMUNOLOGY

Membrane-Dependent Modulation of the mTOR Activator Rheb: NMR Observations of a GTPase Tethered to a Lipid-Bilayer Nanodisc

(2013) Mohammad T. Mazhab-Jafari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

(2013) Hugo Lavoie et al.   Nature Chemical Biology

Defining the structural relationship between kainate-receptor deactivation and desensitization

(2013) G Brent Dawe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

(2013) Elena Seiradake et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The spatial structure of cell signaling systems

(2013) Ruth Nussinov   PHYSICAL BIOLOGY

The molecular basis of targeting protein kinases in cancer therapeutics

(2013) Chung-Jung Tsai et al.   SEMINARS IN CANCER BIOLOGY

Deformation of a two-domain lipid bilayer due to asymmetric insertion of lipid-modified Ras peptides

(2013) Zhenlong Li et al.   Soft Matter

Allosteric Conformational Barcodes Direct Signaling in the Cell

(2013) Ruth Nussinov et al.   STRUCTURE

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

The role of cholesterol on the activity and stability of neurotensin receptor 1

(2012) Joanne Oates et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

N-Ras Forms Dimers at POPC Membranes

(2012) Jörn Güldenhaupt et al.   BIOPHYSICAL JOURNAL

Protein dynamics and conformational selection in bidirectional signal transduction

(2012) Ruth Nussinov et al.   BMC BIOLOGY

Eph/ephrin signalling during development

(2012) R. Klein   DEVELOPMENT

The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction

(2012) Shobhna Kapoor et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Vav1 Oncogenic Mutation Inhibits T Cell Receptor-induced Calcium Mobilization through Inhibition of Phospholipase Cγ1 Activation

(2012) Mira Knyazhitsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A conserved role of IQGAP1 in regulating TOR complex 1

(2012) Y. K. Tekletsadik et al.   JOURNAL OF CELL SCIENCE

IQGAP1: A Regulator of Intracellular Spacetime Relativity

(2012) S. Malarkannan et al.   JOURNAL OF IMMUNOLOGY

Cholesterol Modulates the Structure, Binding Modes, and Energetics of Caveolin–Membrane Interactions

(2012) Durba Sengupta   JOURNAL OF PHYSICAL CHEMISTRY B

Dissociation of the K-Ras4B/PDEδ Complex upon Contact with Lipid Membranes: Membrane Delivery Instead of Extraction

(2012) Katrin Weise et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational states of the kinase Lck regulate clustering in early T cell signaling

(2012) Jérémie Rossy et al.   NATURE IMMUNOLOGY

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Structural Insights into the Assembly of Large Oligomeric Signalosomes in the Toll-Like Receptor-Interleukin-1 Receptor Superfamily

(2012) R. Ferrao et al.   Science Signaling

Allosteric post-translational modification codes

(2012) Ruth Nussinov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement

(2012) Dominik Filipp et al.   Frontiers in Immunology

TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity

(2012) Raquel Blanco et al.   Frontiers in Immunology

Interactions between Kinase Scaffold MP1/p14 and Its Endosomal Anchoring Protein p18

(2011) James Magee et al.   BIOCHEMISTRY

IQGAP1 and its binding proteins control diverse biological functions

(2011) Colin D. White et al.   CELLULAR SIGNALLING

A drug-resistant duo

(2011) Hugo Lavoie et al.   NATURE

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

(2011) Poulikos I. Poulikakos et al.   NATURE

Dynamic Allostery: Linkers Are Not Merely Flexible

(2011) Buyong Ma et al.   STRUCTURE

Mechanistic principles of RAF kinase signaling

(2010) Christian M. Udell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Organisation and dynamics of antigen receptors: implications for lymphocyte signalling

(2010) Bebhinn Treanor et al.   CURRENT OPINION IN IMMUNOLOGY

Allostery and population shift in drug discovery

(2010) Gozde Kar et al.   CURRENT OPINION IN PHARMACOLOGY

Spatial organization of transmembrane receptor signalling

(2010) Ioanna Bethani et al.   EMBO JOURNAL

Galectin multimerization and lattice formation are regulated by linker region structure

(2010) L. A. Earl et al.   GLYCOBIOLOGY

Signalling complexes and clusters: functional advantages and methodological hurdles

(2010) M. Cebecauer et al.   JOURNAL OF CELL SCIENCE

Membrane-Mediated Induction and Sorting of K-Ras Microdomain Signaling Platforms

(2010) Katrin Weise et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Signalling ballet in space and time

(2010) Boris N. Kholodenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spatial organization and signal transduction at intercellular junctions

(2010) Boryana N. Manz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

(2010) N. J. Smith et al.   PHARMACOLOGICAL REVIEWS

Ras membrane orientation and nanodomain localization generate isoform diversity

(2010) D. Abankwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of Eph receptor clusters

(2010) J. P. Himanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

(2010) L. Balagopalan et al.   Cold Spring Harbor Perspectives in Biology

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

(2009) Lakshmi Srinivasan et al.   CELL

Compartmentalized signalling: Ras proteins and signalling nanoclusters

(2009) Jasminka Omerovic et al.   FEBS Journal

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

(2009) Chung-Jung Tsai et al.   Molecular BioSystems

Ras acylation, compartmentalization and signaling nanoclusters (Review)

(2009) Yoav I. Henis et al.   MOLECULAR MEMBRANE BIOLOGY

The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways

(2009) Antonio del Sol et al.   STRUCTURE

Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling

(2009) Thomas A. Bowden et al.   STRUCTURE

A novel switch region regulates H-ras membrane orientation and signal output

(2008) Daniel Abankwa et al.   EMBO JOURNAL

Electrostatic Interactions Positively Regulate K-Ras Nanocluster Formation and Function

(2008) S. J. Plowman et al.   MOLECULAR AND CELLULAR BIOLOGY

Galectin-1 Is a Novel Structural Component and a Major Regulator of H-Ras Nanoclusters

(2008) Liron Belanis et al.   MOLECULAR BIOLOGY OF THE CELL

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Using plasma membrane nanoclusters to build better signaling circuits

(2008) Angus S. Harding et al.   TRENDS IN CELL BIOLOGY