Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 39, Issue 10, Pages 457-464Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.07.008
Keywords
signaling pathways; signaling dynamics; crosstalk
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Funding
- Howard Hughes Medical Institute
- National Institutes of Health (NIH)
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The development and maintenance of the many different cell types in metazoan organisms requires robust and diverse intercellular communication mechanisms. Relatively few such signaling pathways have been identified, leading to the question of how such a broad diversity of output is generated from relatively simple signals. Recent studies have revealed complex mechanisms integrating temporal and spatial information to generate diversity in signaling pathway output. We review some general principles of signaling pathways, focusing on transcriptional outputs in Drosophila. We consider the role of spatial and temporal aspects of different transduction pathways and then discuss how recently developed tools and approaches are helping to dissect the complex mechanisms linking pathway stimulation to output.
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