Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes

SERCA control of cell death and survival

(2018) Elie R. Chemaly et al.   CELL CALCIUM

Impairment of endoplasmic reticulum is involved in β-cell dysfunction induced by microcystin-LR

(2017) Yanyan Zhao et al.   ENVIRONMENTAL POLLUTION

Exenatide substantially improves proinsulin conversion and cell survival that augment Ins2 +/Akita beta cell function

(2017) Wei Tang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3

(2017) Stefan Schoebel et al.   NATURE

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation

(2017) Ling Qi et al.   TRENDS IN CELL BIOLOGY

Genomics of Islet (Dys)function and Type 2 Diabetes

(2017) Nathan Lawlor et al.   TRENDS IN GENETICS

Prion-Like Protein Aggregates and Type 2 Diabetes

(2017) Abhisek Mukherjee et al.   Cold Spring Harbor Perspectives in Medicine

A prominent role of PDIA6 in processing of misfolded proinsulin

(2016) Dhana G. Gorasia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Reversibility of Defects in Proinsulin Processing and Islet β-Cell Failure in Obesity-Related Type 2 Diabetes

(2016) Christopher J. Nolan et al.   DIABETES

Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion

(2016) Corey N. Cunningham et al.   DIABETES

SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity

(2016) Xin Tong et al.   DIABETES

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum

(2016) Leena Haataja et al.   DIABETES

Autophagy is a major regulator of beta cell insulin homeostasis

(2016) Yael Riahi et al.   DIABETOLOGIA

PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1

(2016) Daniela Eletto et al.   FASEB JOURNAL

Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress

(2016) Hongliang Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reduced expression of ERp46 under diabetic conditions in β-cells and the effect of liraglutide

(2016) Eugenia Lampropoulou et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Protein disulfide isomerase ameliorates β-cell dysfunction in pancreatic islets overexpressing human islet amyloid polypeptide

(2016) Joel Montane et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Pathogenic Mechanism of Diabetes Development Due to Dysfunction of Unfolded Protein Response

(2016) Yuichi Tsuchiya et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Northern Han Chinese

(2016) Ping Rao et al.   International Journal of Environmental Research and Public Health

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

Thiol-disulfide exchange between the PDI family of oxidoreductases negates the requirement for an oxidase or reductase for each enzyme

(2015) Ojore B.V. Oka et al.   BIOCHEMICAL JOURNAL

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum

(2015) Edward Avezov et al.   BMC BIOLOGY

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis

(2015) Jaeseok Han et al.   DIABETES

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

(2015) Cristina Alarcon et al.   DIABETES

Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo

(2015) Shuaishuai Zhu et al.   DIABETES

Oxidative protein folding: From thiol–disulfide exchange reactions to the redox poise of the endoplasmic reticulum

(2015) Devin A. Hudson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

(2015) Sumaira Z Hasnain et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes☆

(2015) Jinhong Sun et al.   MOLECULAR ASPECTS OF MEDICINE

PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis

(2015) Kaiyu He et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting protein aggregation for the treatment of degenerative diseases

(2015) Yvonne S. Eisele et al.   NATURE REVIEWS DRUG DISCOVERY

Proteomics analysis of rough endoplasmic reticulum in pancreatic beta cells

(2015) Jin-sook Lee et al.   PROTEOMICS

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

(2015) Justin R. Hassler et al.   PLOS BIOLOGY

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97

(2015) Hanneke Hoelen et al.   PLoS One

The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells

(2014) Tongfu Xu et al.   CELL RESEARCH

The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo

(2014) Arne A. Ittner et al.   DIABETOLOGIA

Peroxiredoxin 4 Improves Insulin Biosynthesis and Glucose-induced Insulin Secretion in Insulin-secreting INS-1E Cells

(2014) Ilir Mehmeti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic and Duodenal Homeobox Protein 1 (Pdx-1) Maintains Endoplasmic Reticulum Calcium Levels through Transcriptional Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 2b (SERCA2b) in the Islet β Cell

(2014) Justin S. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic Beta Cells Are Highly Susceptible to Oxidative and ER Stresses during the Development of Diabetes

(2014) Dhana G. Gorasia et al.   JOURNAL OF PROTEOME RESEARCH

Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis

(2014) J. Groenendyk et al.   Science Signaling

Effects of several quinones on insulin aggregation

(2014) Hao Gong et al.   Scientific Reports

Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells

(2014) Taichi Sugawara et al.   Scientific Reports

Improvement of ER stress-induced diabetes by stimulating autophagy

(2013) Etty Bachar-Wikstrom et al.   Autophagy

Effect of Liraglutide on endoplasmic reticulum stress in diabetes

(2013) Linlin Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucokinase Activation Ameliorates ER Stress-Induced Apoptosis in Pancreatic  -Cells

(2013) J. Shirakawa et al.   DIABETES

GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice

(2013) T. Teodoro-Morrison et al.   DIABETOLOGIA

Circulating Levels of IL-1B+IL-6 Cause ER Stress and Dysfunction in Islets From Prediabetic Male Mice

(2013) Christina M. O'Neill et al.   ENDOCRINOLOGY

Diabetes mellitus due to the toxic misfolding of proinsulin variants

(2013) Michael A. Weiss   FEBS LETTERS

Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-induced Endoplasmic Reticulum Stress

(2013) Jordan Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux

(2013) Dawid Krokowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Secretion and Ca2+Dynamics in β-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin

(2013) Rong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic  -cells

(2013) A. Tiwari et al.   JOURNAL OF CELL SCIENCE

Dominant protein interactions that influence the pathogenesis of conformational diseases

(2013) Jordan Wright et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects

(2013) Jill M. Fritz et al.   MOLECULAR BIOLOGY OF THE CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Insulin Therapy for Pre-Hyperglycemic Beta-Cell Endoplasmic Reticulum Crowding

(2013) Afaf Absood et al.   PLoS One

Oligomerization of Peptides LVEALYL and RGFFYT and Their Binding Affinity to Insulin

(2013) Hsin-Lin Chiang et al.   PLoS One

Islet inflammation: a unifying target for diabetes treatment?

(2013) Yumi Imai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding

(2013) Yoshimi Sato et al.   Scientific Reports

Insulin Biosynthetic Interaction Network Component, TMEM24, Facilitates Insulin Reserve Pool Release

(2013) Anita Pottekat et al.   Cell Reports

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes

(2012) E. Bachar-Wikstrom et al.   DIABETES

Proinsulin Intermolecular Interactions during Secretory Trafficking in Pancreatic β Cells

(2012) Leena Haataja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling Proteostasis and Developmentin Vitrowith a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK

(2012) Heather P. Harding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

(2012) Masahiro Usui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Therapeutic Impact of Leptin on Diabetes, Diabetic Complications, and Longevity in Insulin-Deficient Diabetic Mice

(2011) M. Naito et al.   DIABETES

Early insulin therapy prevents beta cell loss in a mouse model for permanent neonatal diabetes (Munich Ins2 C95S)

(2011) S. Kautz et al.   DIABETOLOGIA

Endoplasmic Reticulum Oxidoreductin-1-Like β (ERO1lβ) Regulates Susceptibility to Endoplasmic Reticulum Stress and Is Induced by Insulin Flux in β-Cells

(2011) Cynthia Khoo et al.   ENDOCRINOLOGY

Action of Protein Disulfide Isomerase on Proinsulin Exit from Endoplasmic Reticulum of Pancreatic β-Cells

(2011) Gautam Rajpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice

(2011) Hong Chen et al.   PEPTIDES

Control of Precursor Maturation and Disposal Is an Early Regulative Mechanism in the Normal Insulin Production of Pancreatic β-Cells

(2011) Jie Wang et al.   PLoS One

Substrate-Favored Lysosomal and Proteasomal Pathways Participate in the Normal Balance Control of Insulin Precursor Maturation and Disposal in β-Cells

(2011) Xiaoping Zhang et al.   PLoS One

Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion

(2011) A.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Overcrowding as a Mechanism of β-Cell Dysfunction in Diabetes

(2010) F. Despa   BIOPHYSICAL JOURNAL

Endoplasmic reticulum stress response in an INS-1 pancreatic β-cell line with inducible expression of a folding-deficient proinsulin

(2010) Taila Hartley et al.   BMC CELL BIOLOGY

PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway

(2010) Sounak Gupta et al.   DIABETES

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

(2010) M. Cnop et al.   DIABETES OBESITY & METABOLISM

ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

(2010) Ester Zito et al.   JOURNAL OF CELL BIOLOGY

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

(2010) Sonya G. Fonseca et al.   JOURNAL OF CLINICAL INVESTIGATION

Wolcott-Rallison syndrome

(2010) Cécile Julier et al.   Orphanet Journal of Rare Diseases

Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

(2010) Ming Liu et al.   PLoS One

Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis

(2010) I. Garin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Stress in Pancreatic   Cells: The Thin Red Line Between Adaptation and Failure

(2010) D. L. Eizirik et al.   Science Signaling

Oxidative Protein Folding in the Secretory Pathway and Redox Signaling Across Compartments and Cells

(2010) Éva Margittai et al.   TRAFFIC

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

(2010) Ming Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

GLP-1 receptor agonist attenuates endoplasmic reticulum stress-mediated β-cell damage in Akita mice

(2010) Shunsuke Yamane et al.   Journal of Diabetes Investigation

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

ERp46 is reduced by high glucose and regulates insulin content in pancreatic β-cells

(2009) Avra Alberti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes

(2009) Sindhu Rajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tyrosine Autofluorescence as a Measure of Bovine Insulin Fibrillation

(2009) Innocent B. Bekard et al.   BIOPHYSICAL JOURNAL

Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation

(2009) Daorong Feng et al.   BMC CELL BIOLOGY

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

(2009) Sung Hoon Back et al.   Cell Metabolism

Proinsulin and the Genetics of Diabetes Mellitus

(2009) Michael A. Weiss   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis for insulin fibril assembly

(2009) Magdalena I. Ivanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dilation of the endoplasmic reticulum in beta cells due to molecular overcrowding?

(2008) F. Despa   BIOPHYSICAL CHEMISTRY

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic β-Cells

(2008) Liling Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The In Vitro Oxidative Folding of the Insulin Superfamily

(2007) Zhan-Yun Guo et al.   ANTIOXIDANTS & REDOX SIGNALING