Peroxiredoxin 4 Improves Insulin Biosynthesis and Glucose-induced Insulin Secretion in Insulin-secreting INS-1E Cells

GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum

(2014) Thomas Ramming et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deregulation of Pancreas-Specific Oxidoreductin ERO1  in the Pathogenesis of Diabetes Mellitus

(2014) M. Awazawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Peroxiredoxin 4 Protects Against Nonalcoholic Steatohepatitis and Type 2 Diabetes in a Nongenetic Mouse Model

(2013) Atsunori Nabeshima et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione Peroxidase 7 Utilizes Hydrogen Peroxide Generated by Ero1α to Promote Oxidative Protein Folding

(2013) Lei Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Forming disulfides in the endoplasmic reticulum

(2013) Ojore B.V. Oka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Modulation of the peroxiredoxin system by cytokines in insulin-producing RINm5F cells: Down-regulation of PRDX6 increases susceptibility of beta cells to oxidative stress

(2013) Flavia M.M. Paula et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding

(2013) Yoshimi Sato et al.   Scientific Reports

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

PRDX4, an Endoplasmic Reticulum-Localized Peroxiredoxin at the Crossroads Between Enzymatic Oxidative Protein Folding and Nonenzymatic Protein Oxidation

(2012) Ester Zito   ANTIOXIDANTS & REDOX SIGNALING

The H2O2-sensitive HyPer protein targeted to the endoplasmic reticulum as a mirror of the oxidizing thiol–disulfide milieu

(2012) Ilir Mehmeti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice

(2012) Ester Zito et al.   MOLECULAR CELL

Protein-Folding Homeostasis in the Endoplasmic Reticulum and Nutritional Regulation

(2012) D. Ron et al.   Cold Spring Harbor Perspectives in Biology

Peroxides and Peroxidases in the Endoplasmic Reticulum: Integrating Redox Homeostasis and Oxidative Folding

(2011) Taichi Kakihana et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4

(2011) Xi Wang et al.   BIOCHEMICAL JOURNAL

Endoplasmic Reticulum Oxidoreductin-1-Like β (ERO1lβ) Regulates Susceptibility to Endoplasmic Reticulum Stress and Is Induced by Insulin Flux in β-Cells

(2011) Cynthia Khoo et al.   ENDOCRINOLOGY

Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle

(2011) Zhenbo Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxiredoxin Functions as a Peroxidase and a Regulator and Sensor of Local Peroxides

(2011) Sue Goo Rhee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation

(2011) Van Dat Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria

(2011) Ewa Gurgul-Convey et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Overexpression of Peroxiredoxin 4 Protects Against High-Dose Streptozotocin-Induced Diabetes by Suppressing Oxidative Stress and Cytokines in Transgenic Mice

(2010) Yan Ding et al.   ANTIOXIDANTS & REDOX SIGNALING

Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum

(2010) Timothy J Tavender et al.   EMBO JOURNAL

Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formation

(2010) T. J. Tavender et al.   JOURNAL OF CELL SCIENCE

Peroxiredoxin III protects pancreatic β cells from apoptosis

(2010) Gabriele Wolf et al.   JOURNAL OF ENDOCRINOLOGY

Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status

(2010) Ilir Mehmeti et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin

(2010) Ester Zito et al.   MOLECULAR CELL

Methods for detection and measurement of hydrogen peroxide inside and outside of cells

(2010) Sue Goo Rhee et al.   MOLECULES AND CELLS

The Role of Dehydroascorbate in Disulfide Bond Formation

(2009) Mirva J. Saaranen et al.   ANTIOXIDANTS & REDOX SIGNALING

Efficient Peroxide-Mediated Oxidative Refolding of a Protein at Physiological pH and Implications for Oxidative Folding in the Endoplasmic Reticulum

(2008) Anna–Riikka Karala et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells

(2008) Timothy J. Tavender et al.   BIOCHEMICAL JOURNAL

Peroxiredoxin 4knockout results in elevated spermatogenic cell death via oxidative stress

(2008) Yoshihito Iuchi et al.   BIOCHEMICAL JOURNAL

A novel disulphide switch mechanism in Ero1α balances ER oxidation in human cells

(2008) Christian Appenzeller-Herzog et al.   EMBO JOURNAL

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS