Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-induced Endoplasmic Reticulum Stress

Diabetes mellitus due to the toxic misfolding of proinsulin variants

(2013) Michael A. Weiss   FEBS LETTERS

Endoplasmic reticulum: reduced and oxidized glutathione revisited

(2013) J. Birk et al.   JOURNAL OF CELL SCIENCE

Dominant protein interactions that influence the pathogenesis of conformational diseases

(2013) Jordan Wright et al.   JOURNAL OF CLINICAL INVESTIGATION

UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum

(2013) Sean P. Ferris et al.   MOLECULAR BIOLOGY OF THE CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise

(2013) Julia Birk et al.   Frontiers in Genetics

A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense

(2013) Udayakumar Karunakaran et al.   Diabetes & Metabolism Journal

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

The Physiological Functions of Mammalian Endoplasmic Oxidoreductin 1: On Disulfides and More

(2012) Thomas Ramming et al.   ANTIOXIDANTS & REDOX SIGNALING

Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes

(2012) M. Liu et al.   DIABETES

Proinsulin Intermolecular Interactions during Secretory Trafficking in Pancreatic β Cells

(2012) Leena Haataja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperactivity of the Ero1α Oxidase Elicits Endoplasmic Reticulum Stress but No Broad Antioxidant Response

(2012) Henning Gram Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling Proteostasis and Developmentin Vitrowith a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK

(2012) Heather P. Harding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-Folding Homeostasis in the Endoplasmic Reticulum and Nutritional Regulation

(2012) D. Ron et al.   Cold Spring Harbor Perspectives in Biology

Endoplasmic Reticulum Oxidoreductin-1-Like β (ERO1lβ) Regulates Susceptibility to Endoplasmic Reticulum Stress and Is Induced by Insulin Flux in β-Cells

(2011) Cynthia Khoo et al.   ENDOCRINOLOGY

Action of Protein Disulfide Isomerase on Proinsulin Exit from Endoplasmic Reticulum of Pancreatic β-Cells

(2011) Gautam Rajpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum

(2011) C. Appenzeller-Herzog   JOURNAL OF CELL SCIENCE

Multiple ways to make disulfides

(2011) Neil J. Bulleid et al.   TRENDS IN BIOCHEMICAL SCIENCES

Redox State of the Endoplasmic Reticulum Is Controlled by Ero1L-alpha and Intraluminal Calcium

(2010) Balázs Enyedi et al.   ANTIOXIDANTS & REDOX SIGNALING

The endoplasmic reticulum stress response in the pancreatic β-cell

(2010) A. Volchuk et al.   DIABETES OBESITY & METABOLISM

A Small Molecule Inhibitor of Endoplasmic Reticulum Oxidation 1 (ERO1) with Selectively Reversible Thiol Reactivity

(2010) Jaime D. Blais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

(2010) Ester Zito et al.   JOURNAL OF CELL BIOLOGY

Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formation

(2010) T. J. Tavender et al.   JOURNAL OF CELL SCIENCE

Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin

(2010) Ester Zito et al.   MOLECULAR CELL

Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

(2010) Ming Liu et al.   PLoS One

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

(2010) Ming Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes

(2009) Sindhu Rajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted

(2009) Soo-Young Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

(2009) Sung Hoon Back et al.   Cell Metabolism

Misfolded Proinsulin Affects Bystander Proinsulin in Neonatal Diabetes

(2009) Israel Hodish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proinsulin and the Genetics of Diabetes Mellitus

(2009) Michael A. Weiss   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel disulphide switch mechanism in Ero1α balances ER oxidation in human cells

(2008) Christian Appenzeller-Herzog et al.   EMBO JOURNAL

Low reduction potential of Ero1α regulatory disulphides ensures tight control of substrate oxidation

(2008) Karl M Baker et al.   EMBO JOURNAL

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Reconstitution of Human Ero1-Lα/Protein-Disulfide Isomerase Oxidative Folding Pathwayin Vitro

(2008) Lei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic β-Cells

(2008) Liling Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY