Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?

Candidate Drug Targets for Prevention or Modification of Epilepsy

(2015) Nicholas H. Varvel et al.   Annual Review of Pharmacology and Toxicology

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

(2015) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Blood–brain barrier dysfunction, seizures and epilepsy

(2015) E.A. van Vliet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

P2X7 Receptor Inhibition Interrupts the Progression of Seizures in Immature Rats and Reduces Hippocampal Damage

(2014) Guillaume Mesuret et al.   CNS Neuroscience & Therapeutics

A Novel, Noninvasive, Predictive Epilepsy Biomarker with Clinical Potential

(2014) M. Choy et al.   JOURNAL OF NEUROSCIENCE

The challenge and promise of anti-epileptic therapy development in animal models

(2014) Michele Simonato et al.   LANCET NEUROLOGY

Dietary treatment in adults with refractory epilepsy: A review

(2014) P. Klein et al.   NEUROLOGY

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: Evaluation in a rat epilepsy model

(2014) Renée Marie Bogdanović et al.   NEUROPHARMACOLOGY

Biomarkers of Epileptogenesis: Psychiatric Comorbidities (?)

(2014) Andres M. Kanner et al.   Neurotherapeutics

Past and Present Definitions of Epileptogenesis and Its Biomarkers

(2014) Asla Pitkänen et al.   Neurotherapeutics

Molecular magnetic resonance imaging of brain–immune interactions

(2014) Maxime Gauberti et al.   Frontiers in Cellular Neuroscience

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

Cyclooxygenase-2 in epilepsy

(2013) Asheebo Rojas et al.   EPILEPSIA

The dual role of TNF-α and its receptors in seizures

(2013) Silvia Balosso et al.   EXPERIMENTAL NEUROLOGY

Opposing actions of hippocampus TNFα receptors on limbic seizure susceptibility

(2013) Marc S. Weinberg et al.   EXPERIMENTAL NEUROLOGY

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy

(2013) F.M. Noe et al.   NEUROBIOLOGY OF DISEASE

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

(2013) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway

(2013) B. Bonaz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Specific Imaging of Inflammation with the 18kDa Translocator Protein Ligand DPA-714 in Animal Models of Epilepsy and Stroke

(2013) Denise Harhausen et al.   PLoS One

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Inflammatory pathways of seizure disorders

(2013) Nicola Marchi et al.   TRENDS IN NEUROSCIENCES

Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

(2013) Jianxiong Jiang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy

(2013) Stefanie Dedeurwaerdere et al.   EJNMMI Research

Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage

(2012) Laura Librizzi et al.   ANNALS OF NEUROLOGY

Synthesis and evaluation of [18F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)

(2012) S. Nag et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Epileptic Encephalitis: The Role of the Innate and Adaptive Immune System

(2012) Jan Bauer et al.   BRAIN PATHOLOGY

Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats

(2012) Lei Ma et al.   BRAIN RESEARCH

Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology

(2012) Federica Frigerio et al.   EPILEPSIA

In vivo imaging of glia activation using1H-magnetic resonance spectroscopy to detect putative biomarkers of tissue epileptogenicity

(2012) Marta Filibian et al.   EPILEPSIA

Clinical characteristics, risk factors and pre-surgical evaluation of post-infectious epilepsy

(2012) J. Sellner et al.   EUROPEAN JOURNAL OF NEUROLOGY

Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

(2012) Uwe Heinemann et al.   GLIA

Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling

(2012) Christian Steinhäuser et al.   GLIA

Astrocyte immune responses in epilepsy

(2012) Eleonora Aronica et al.   GLIA

Imaging seizure-induced inflammation using an antibody targeted iron oxide contrast agent

(2012) Ben A. Duffy et al.   NEUROIMAGE

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

(2012) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain inflammation as a biomarker in epilepsy

(2011) Annamaria Vezzani et al.   Biomarkers in Medicine

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

(2011) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

Molecular cascades that mediate the influence of inflammation on epilepsy

(2011) Alon Friedman et al.   EPILEPSIA

The ketogenic diet: What has science taught us?

(2011) Jong M. Rho et al.   EPILEPSY RESEARCH

Epilepsy and brain inflammation

(2011) Annamaria Vezzani et al.   EXPERIMENTAL NEUROLOGY

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

Epileptiform Activity Induces Vascular Remodeling and Zonula Occludens 1 Downregulation in Organotypic Hippocampal Cultures: Role of VEGF Signaling Pathways

(2011) M. Morin-Brureau et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

Inflammation and prevention of epileptogenesis

(2011) Teresa Ravizza et al.   NEUROSCIENCE LETTERS

Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA

(2010) Stéphane Auvin et al.   EPILEPSIA

Epileptogenesis Provoked by Prolonged Experimental Febrile Seizures: Mechanisms and Biomarkers

(2010) C. M. Dube et al.   JOURNAL OF NEUROSCIENCE

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Intravenous immunoglobulin therapy in intractable childhood epilepsy: Open-label study and review of the literature

(2009) Mohamad A. Mikati et al.   EPILEPSY & BEHAVIOR

Neutralization of interleukin-1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice

(2009) Fredrik Clausen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ketogenic Diets: An Update for Child Neurologists

(2009) Eric H. Kossoff et al.   JOURNAL OF CHILD NEUROLOGY

Cellular injury and neuroinflammation in children with chronic intractable epilepsy

(2009) Jieun Choi et al.   Journal of Neuroinflammation

Age-dependent vascular changes induced by status epilepticus in rat forebrain: Implications for epileptogenesis

(2009) Jessica Marcon et al.   NEUROBIOLOGY OF DISEASE

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

(2009) Erwin A. van Vliet et al.   NEUROPHARMACOLOGY

Hitting a moving target: Basic mechanisms of recovery from acquired developmental brain injury

(2009) Christopher C. Giza et al.   Developmental Neurorehabilitation

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

The role of cytokines in the pathophysiology of epilepsy

(2008) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE

Antagonism of peripheral inflammation reduces the severity of status epilepticus

(2008) Nicola Marchi et al.   NEUROBIOLOGY OF DISEASE

Seizure-Induced Up-Regulation of P-Glycoprotein at the Blood-Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling

(2007) B. Bauer et al.   MOLECULAR PHARMACOLOGY

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy

(2007) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE