Past and Present Definitions of Epileptogenesis and Its Biomarkers

Basic mechanisms of catastrophic epilepsy – Overview from animal models

(2013) Aristea S. Galanopoulou   BRAIN & DEVELOPMENT

Genetics of the epilepsies

(2013) Ingo Helbig et al.   CURRENT OPINION IN NEUROLOGY

Predictive biomarkers in adult gliomas

(2013) Laure Thomas et al.   CURRENT OPINION IN ONCOLOGY

Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy

(2013) Gabi Dezsi et al.   EPILEPSIA

High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy

(2013) Kathleen Heng et al.   EPILEPSIA

International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods

(2013) Ingmar Blümcke et al.   EPILEPSIA

Epilepsy biomarkers

(2013) Jerome Engel et al.   EPILEPSIA

Prophylactic treatment with melatonin after status epilepticus: Effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy

(2013) Jana Tchekalarova et al.   EPILEPSY & BEHAVIOR

Studying Autism in Rodent Models: Reconciling Endophenotypes with Comorbidities

(2013) Andrew Argyropoulos et al.   Frontiers in Human Neuroscience

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

(2013) Rebecca L. Williams-Karnesky et al.   JOURNAL OF CLINICAL INVESTIGATION

Ceftriaxone Treatment after Traumatic Brain Injury Restores Expression of the Glutamate Transporter, GLT-1, Reduces Regional Gliosis, and Reduces Post-Traumatic Seizures in the Rat

(2013) Grant S. Goodrich et al.   JOURNAL OF NEUROTRAUMA

De novo mutations in epileptic encephalopathies

(2013) et al.   NATURE

Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes

(2013) Johannes R Lemke et al.   NATURE GENETICS

GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction

(2013) Gaetan Lesca et al.   NATURE GENETICS

Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1

(2013) Gemma L Carvill et al.   NATURE GENETICS

GRIN2A mutations cause epilepsy-aphasia spectrum disorders

(2013) Gemma L Carvill et al.   NATURE GENETICS

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy

(2013) F.M. Noe et al.   NEUROBIOLOGY OF DISEASE

The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy

(2013) H.L. Grabenstatter et al.   NEUROBIOLOGY OF DISEASE

Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy

(2013) Gumei Liu et al.   NEURON

Regulatory Innovation and Drug Development for Early-Stage Alzheimer's Disease

(2013) Nicholas Kozauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury

(2013) Dongjun Guo et al.   PLoS One

Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats

(2012) Lei Ma et al.   BRAIN RESEARCH

Finding a better drug for epilepsy: Preclinical screening strategies and experimental trial design

(2012) Michele Simonato et al.   EPILEPSIA

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

(2012) Erwin A. van Vliet et al.   EPILEPSIA

Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy

(2012) Marta Rattka et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ion channels in genetic and acquired forms of epilepsy

(2012) Holger Lerche et al.   JOURNAL OF PHYSIOLOGY-LONDON

De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy

(2012) Giulia Barcia et al.   NATURE GENETICS

mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy

(2012) Emilio Russo et al.   NEUROPHARMACOLOGY

Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy

(2012) Anna Sliwa et al.   NEUROSCIENCE LETTERS

Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model

(2012) Fei Gao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

(2011) Shawn McClelland et al.   ANNALS OF NEUROLOGY

Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity

(2011) Emilio Russo et al.   BEHAVIOURAL BRAIN RESEARCH

Biomarkers in epilepsy: foreword

(2011) Jerome Engel   Biomarkers in Medicine

Molecular Genetics of Neuronal Migration Disorders

(2011) Judy S. Liu   Current Neurology and Neuroscience Reports

Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model

(2011) Emilio Russo et al.   EPILEPSIA

Immune-mediated epilepsies

(2011) Tiziana Granata et al.   EPILEPSIA

Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

(2011) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice

(2010) Elin Lehrmann et al.   EPILEPSIA

The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat

(2010) F. Edward Dudek et al.   EPILEPSIA

Therapeutic approaches to epileptogenesis-Hope on the horizon

(2010) Asla Pitkänen   EPILEPSIA

The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1

(2010) Ingmar Blümcke et al.   EPILEPSIA

Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009

(2010) Anne T. Berg et al.   EPILEPSIA

Does ketogenic diet alter seizure sensitivity and cell loss following fluid percussion injury?

(2010) Philip A. Schwartzkroin et al.   EPILEPSY RESEARCH

Post-traumatic seizure susceptibility is attenuated by hypothermia therapy

(2010) Coleen M. Atkins et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

(2010) Nadine Polascheck et al.   EXPERIMENTAL NEUROLOGY

Development of Postinfection Epilepsy After Theiler's Virus Infection of C57BL/6 Mice

(2010) Kerry-Ann A. Stewart et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Disease-Modifying Effects of Phenobarbital and the NKCC1 Inhibitor Bumetanide in the Pilocarpine Model of Temporal Lobe Epilepsy

(2010) C. Brandt et al.   JOURNAL OF NEUROSCIENCE

Minozac Treatment Prevents Increased Seizure Susceptibility in a Mouse “Two-Hit” Model of Closed Skull Traumatic Brain Injury and Electroconvulsive Shock-Induced Seizures

(2010) MaryAnn Chrzaszcz et al.   JOURNAL OF NEUROTRAUMA

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Animal models of focal cortical dysplasia and tuberous sclerosis complex: Recent progress toward clinical applications

(2009) Michael Wong   EPILEPSIA

Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy

(2009) Emilio Russo et al.   EPILEPSIA

Spike–wave discharges are necessary for the expression of behavioral depression-like symptoms

(2009) Karine Yu Sarkisova et al.   EPILEPSIA

Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model

(2009) Julio Echegoyen et al.   EPILEPSY RESEARCH

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

(2009) L. Holtman et al.   EPILEPSY RESEARCH

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model

(2009) B. Paradiso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

(2008) Ling-Hui Zeng et al.   ANNALS OF NEUROLOGY

Erythropoietin reduces epileptogenic processes following status epilepticus

(2008) Kon Chu et al.   EPILEPSIA

Early treatment suppresses the development of spike-wave epilepsy in a rat model

(2008) Hal Blumenfeld et al.   EPILEPSIA

Navigating the channels and beyond: unravelling the genetics of the epilepsies

(2008) Ingo Helbig et al.   LANCET NEUROLOGY

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE