Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

(2011) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

Introduction

(2011) Annamaria Vezzani et al.   EPILEPSIA

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

Epileptiform Activity Induces Vascular Remodeling and Zonula Occludens 1 Downregulation in Organotypic Hippocampal Cultures: Role of VEGF Signaling Pathways

(2011) M. Morin-Brureau et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA

(2010) Stéphane Auvin et al.   EPILEPSIA

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold

(2010) Marta Gómez-Gonzalo et al.   PLOS BIOLOGY

Blood–brain barrier breakdown-inducing astrocytic transformation: Novel targets for the prevention of epilepsy

(2009) Alon Friedman et al.   EPILEPSY RESEARCH

Contributions of peripheral inflammation to seizure susceptibility: Cytokines and brain excitability

(2009) Kiarash Riazi et al.   EPILEPSY RESEARCH

Age-dependent vascular changes induced by status epilepticus in rat forebrain: Implications for epileptogenesis

(2009) Jessica Marcon et al.   NEUROBIOLOGY OF DISEASE

Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro

(2008) Vadym Gnatkovsky et al.   ANNALS OF NEUROLOGY

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

Research priorities in epilepsy for the next decade-A representative view of the European scientific community: Summary of the ILAE Epilepsy Research Workshop, Brussels, 17-18 January 2008

(2008) Michel Baulac et al.   EPILEPSIA

Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7receptor-mediated IL-1β release

(2008) Liliana Bernardino et al.   JOURNAL OF NEUROCHEMISTRY

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE

Antagonism of peripheral inflammation reduces the severity of status epilepticus

(2008) Nicola Marchi et al.   NEUROBIOLOGY OF DISEASE

Role of Brain Inflammation in Epileptogenesis

(2008) Jieun Choi et al.   YONSEI MEDICAL JOURNAL

Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex

(2007) K. Boer et al.   EPILEPSY RESEARCH

Seizure-Induced Up-Regulation of P-Glycoprotein at the Blood-Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling

(2007) B. Bauer et al.   MOLECULAR PHARMACOLOGY

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy

(2007) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE