Molecular cascades that mediate the influence of inflammation on epilepsy

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

(2011) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA

(2010) Stéphane Auvin et al.   EPILEPSIA

Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy

(2010) Linda Holtman et al.   EPILEPSY RESEARCH

Epileptogenesis Provoked by Prolonged Experimental Febrile Seizures: Mechanisms and Biomarkers

(2010) C. M. Dube et al.   JOURNAL OF NEUROSCIENCE

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Inflammation enhances epileptogenesis in the developing rat brain

(2010) Stéphane Auvin et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

(2010) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of interleukin-1β in febrile seizures

(2009) James G. Heida et al.   BRAIN & DEVELOPMENT

Blood–brain barrier breakdown-inducing astrocytic transformation: Novel targets for the prevention of epilepsy

(2009) Alon Friedman et al.   EPILEPSY RESEARCH

Contributions of peripheral inflammation to seizure susceptibility: Cytokines and brain excitability

(2009) Kiarash Riazi et al.   EPILEPSY RESEARCH

Transcriptome Profiling Reveals TGF-  Signaling Involvement in Epileptogenesis

(2009) L. P. Cacheaux et al.   JOURNAL OF NEUROSCIENCE

Targeting Prostaglandin E2 EP1 Receptors Prevents Seizure-Associated P-glycoprotein Up-Regulation

(2009) A. Pekcec et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Barrier to electrical storms

(2009) Richard M. Ransohoff   NATURE

Age-dependent vascular changes induced by status epilepticus in rat forebrain: Implications for epileptogenesis

(2009) Jessica Marcon et al.   NEUROBIOLOGY OF DISEASE

Molecular and functional interactions between tumor necrosis factor-alpha receptors and the glutamatergic system in the mouse hippocampus: Implications for seizure susceptibility

(2009) S. Balosso et al.   NEUROSCIENCE

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

White matter angiopathy is common in pediatric patients with intractable focal epilepsies

(2008) Michelle Hildebrandt et al.   EPILEPSIA

Neonatal inflammation produces selective behavioural deficits and alters N-methyl-d-aspartate receptor subunit mRNA in the adult rat brain

(2008) E.-M. Harré et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Postnatal Inflammation Increases Seizure Susceptibility in Adult Rats

(2008) M. A. Galic et al.   JOURNAL OF NEUROSCIENCE

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

(2008) Jiyun V. Kim et al.   NATURE

Brain inflammation initiates seizures

(2008) Jonathan K Kleen et al.   NATURE MEDICINE

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE

NMDA-induced seizure intensity is enhanced in COX-2 deficient mice

(2008) Christopher D. Toscano et al.   NEUROTOXICOLOGY

Seizure-Induced Up-Regulation of P-Glycoprotein at the Blood-Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling

(2007) B. Bauer et al.   MOLECULAR PHARMACOLOGY

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy

(2007) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE