The role of PPARγ-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

A new target for squamous cell skin cancer?

(2015) Dongwon Kim et al.   EXPERIMENTAL DERMATOLOGY

Various peroxisome proliferator-activated receptor (PPAR)-γagonists differently induce differentiation of cultured human keratinocytes

(2015) Yan Yan et al.   EXPERIMENTAL DERMATOLOGY

PPARα ligand clofibrate ameliorates blood pressure and vascular reactivity in spontaneously hypertensive rats

(2014) Zivar Yousefipour et al.   ACTA PHARMACOLOGICA SINICA

Accumulating Evidence for the Association and Shared Pathogenic Mechanisms Between Psoriasis and Cardiovascular-related Comorbidities

(2014) Julia Shlyankevich et al.   AMERICAN JOURNAL OF MEDICINE

Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes

(2014) Raymond E. Soccio et al.   Cell Metabolism

Photoaging

(2014) Anne Han et al.   DERMATOLOGIC CLINICS

Orange peel extract, containing high levels of polymethoxyflavonoid, suppressed UVB-induced COX-2 expression and PGE2production in HaCaT cells through PPAR-γactivation

(2014) Norihiro Yoshizaki et al.   EXPERIMENTAL DERMATOLOGY

New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease

(2014) Amirhossein Sahebkar et al.   EXPERT OPINION ON PHARMACOTHERAPY

The role of nitrated fatty acids and peroxisome proliferator-activated receptor gamma in modulating inflammation

(2014) Venkata Ramireddy Narala et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Expression of steroidogenic enzymes in human sebaceous glands

(2014) Takayoshi Inoue et al.   JOURNAL OF ENDOCRINOLOGY

Hydroxyeicosapentaenoic acids from the Pacific krill show high ligand activities for PPARs

(2014) Hidetoshi Yamada et al.   JOURNAL OF LIPID RESEARCH

Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice

(2014) Mahmut Sozmen et al.   Journal of Veterinary Science

Hydroxyoctadecadienoic Acids Regulate Apoptosis in Human THP-1 Cells in a PPARγ-Dependent Manner

(2014) Venkat N. Vangaveti et al.   LIPIDS

The role of leukotrienes in immunopathogenesis of rheumatoid arthritis

(2014) Bahman Yousefi et al.   Modern Rheumatology

Minireview: Challenges and Opportunities in Development of PPAR Agonists

(2014) Matthew B. Wright et al.   MOLECULAR ENDOCRINOLOGY

In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators

(2014) Wen-Hui Lien et al.   NATURE CELL BIOLOGY

PPARγ ligand ciglitazone inhibits TNFαα-induced ICAM-1 in human airway smooth muscle cells

(2014) Chien-Da Huang et al.   Biomedical Journal

A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses

(2013) Jun Wei et al.   ANNALS OF THE RHEUMATIC DISEASES

Pioglitazone and risk of bladder cancer: a meta-analysis of controlled studies

(2013) M. Ferwana et al.   DIABETIC MEDICINE

Dihydrodehydrodiisoeugenol enhances adipocyte differentiation and decreases lipolysis in murine and human cells

(2013) Katja Nehrenheim et al.   EXPERIMENTAL DERMATOLOGY

Expressions of peroxisome proliferator-activated receptors (PPARs) are directly influenced by permeability barrier abrogation and inflammatory cytokines and depressed PPARα modulates expressions of chemokines and epidermal differentiation-related molecule

(2013) Yasuko Adachi et al.   EXPERIMENTAL DERMATOLOGY

Preclinical Studies of a Specific PPARγ Modulator in the Control of Skin Inflammation

(2013) Arianna Mastrofrancesco et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation?

(2013) Yuval Ramot et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PPARγ-Mediated and Arachidonic Acid–Dependent Signaling Is Involved in Differentiation and Lipid Production of Human Sebocytes

(2013) Aniko Dozsa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche

(2013) Matthew J Harries et al.   JOURNAL OF PATHOLOGY

Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway

(2013) Ming-Chang Chiang et al.   MITOCHONDRION

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Environmental and occupational exposure to chemicals and telomere length in human studies

(2013) Xiao Zhang et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

PPAR-Alpha Agonists as Novel Antiepileptic Drugs: Preclinical Findings

(2013) Monica Puligheddu et al.   PLoS One

Regulation of energy metabolism by long-chain fatty acids

(2013) Manabu T. Nakamura et al.   PROGRESS IN LIPID RESEARCH

Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone

(2013) Rodrigo N Lamounier et al.   Diabetology & Metabolic Syndrome

Ligand-Activated Peroxisome Proliferator-Activated Receptor β/δ Modulates Human Endometrial Cancer Cell Survival

(2013) J. J. Ma et al.   Hormones & Cancer

The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists

(2012) Azadeh Matin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Thiazolidinedione use and cancer incidence in type 2 diabetes: A systematic review and meta-analysis

(2012) I.N. Colmers et al.   DIABETES & METABOLISM

Hospitalised hip fracture risk with rosiglitazone and pioglitazone use compared with other glucose-lowering drugs

(2012) H. M. Colhoun et al.   DIABETOLOGIA

Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ

(2012) Stefania Briganti et al.   EXPERIMENTAL DERMATOLOGY

Zinc gluconate is an agonist of peroxisome proliferator-activated receptor-α in the epidermis

(2012) Carole Poiraud et al.   EXPERIMENTAL DERMATOLOGY

In vivoimaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice

(2012) Noura El-Jamal et al.   EXPERIMENTAL DERMATOLOGY

Thiazolidinedione safety

(2012) Jacqueline Kung et al.   Expert Opinion On Drug Safety

Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators

(2012) Céline Pirat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Balaglitazone: A Second Generation Peroxisome Proliferator-Activated Receptor (PPAR) Gamma (γ) Agonist

(2012) R. Agrawal et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases

(2012) Je-Min Choi et al.   MOLECULES AND CELLS

Linking αMSH with PPARγ in B16-F10 melanoma

(2012) Vittoria Maresca et al.   Pigment Cell & Melanoma Research

Skin-Targeted Inhibition of PPAR β/δ by Selective Antagonists to Treat PPAR β/δ – Mediated Psoriasis-Like Skin Disease In Vivo

(2012) Katrin Hack et al.   PLoS One

5,7-Dimethoxyflavone, an activator of PPARα/γ, inhibits UVB-induced MMP expression in human skin fibroblast cells

(2011) Jae Kyung Kim et al.   EXPERIMENTAL DERMATOLOGY

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

(2011) Mark Boguniewicz et al.   IMMUNOLOGICAL REVIEWS

Peroxisome proliferator–activated receptor γ–mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice

(2011) Kyungsook Jung et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

“Sebocytes’ makeup” - Novel mechanisms and concepts in the physiology of the human sebaceous glands

(2011) Balázs I. Tóth et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

2,4,6-Octatrienoic acid is a novel promoter of melanogenesis and antioxidant defence in normal human melanocytes via PPAR-γ activation

(2011) Enrica Flori et al.   Pigment Cell & Melanoma Research

The Nuclear Hormone Receptor PPARγas a Therapeutic Target in Major Diseases

(2011) Martina Victoria Schmidt et al.   TheScientificWorldJOURNAL

PPARγ inhibits inflammatory reaction in oxidative stress induced human diploid fibloblast

(2010) Young-Hee Lee et al.   CELL BIOCHEMISTRY AND FUNCTION

Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis

(2010) Jun Wei et al.   CURRENT OPINION IN RHEUMATOLOGY

Human Catalase Gene is Regulated by Peroxisome Proliferator Activated Receptor-gamma through a Response Element Distinct from That of Mouse

(2010) Yosuke OKUNO et al.   ENDOCRINE JOURNAL

Discovery and development of selective PPARγ modulators as safe and effective antidiabetic agents

(2010) Lalit S Doshi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Endogenous Ligands for Nuclear Receptors: Digging Deeper

(2010) Michael Schupp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbaprostacyclin, a PPARδ agonist, ameliorates excess lipid accumulation in diabetic rat placentas

(2010) Melisa Kurtz et al.   LIFE SCIENCES

Peroxisome Proliferator-Activated Receptors (PPARs) and the Human Skin

(2009) Pit Sertznig et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation

(2009) Linda Slanec Higgins et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Efficacy and Safety of Combination Acitretin and Pioglitazone Therapy in Patients With Moderate to Severe Chronic Plaque-Type Psoriasis

(2009) Rajan Mittal et al.   ARCHIVES OF DERMATOLOGY

Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor γ Agonist

(2009) Paradi Mirmirani   ARCHIVES OF DERMATOLOGY

Scarring Alopecia and the PPAR-γ Connection

(2009) Matthew J. Harries et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cannabinoids as pharmacotherapies for neuropathic pain: From the bench to the bedside

(2009) Elizabeth J. Rahn et al.   Neurotherapeutics

Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts

(2009) X. Shi-wen et al.   RHEUMATOLOGY

Molecular mechanism of PPAR in the regulation of age-related inflammation

(2008) Jae Heun Chung et al.   AGEING RESEARCH REVIEWS

Activation of peroxisome proliferator-activated receptor gamma suppresses mast cell maturation involved in allergic diseases

(2008) M. Tachibana et al.   ALLERGY

A Retrospective Case Series Review of the Peroxisome Proliferator-Activated Receptor Ligand Rosiglitazone in the Treatment of Atopic Dermatitis

(2008) Ramona Behshad et al.   ARCHIVES OF DERMATOLOGY

Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin®, in resistant solid tumor malignancies

(2008) Paula M. Fracasso et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Systemic PPARγ Ligation Inhibits Allergic Immune Response in the Skin

(2008) Anja Dahten et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Topical Peroxisome Proliferator Activated Receptor Activators Accelerate Postnatal Stratum Corneum Acidification

(2008) Joachim W. Fluhr et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hair Follicle Stem Cell-Specific PPARγ Deletion Causes Scarring Alopecia

(2008) Pratima Karnik et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Association between use of thiazolidinediones or other oral antidiabetics and psoriasis: A population based case-control study

(2008) Yolanda B. Brauchli et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

PPARα/γ Expression and Activity in Mouse and Human Melanocytes and Melanoma Cells

(2008) Linda L. Eastham et al.   PHARMACEUTICAL RESEARCH

LXRα Enhances Lipid Synthesis in SZ95 Sebocytes

(2007) Il Hong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY