Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lin Peng, Huixia Yang, Yao Ye, Zhi Ma, Christina Kuhn, Martina Rahmeh, Sven Mahner, Antonis Makrigiannakis, Udo Jeschke, Viktoria von Schonfeldt
Summary: PPARs play vital roles in pregnancy, and dysfunctions of PPARs may lead to various related pregnancy diseases such as recurrent miscarriage and preeclampsia. This review discusses the impact of regulating PPARs on trophoblast physiological conditions and explores the underlying mechanisms of PPARs in controlling pregnancy-related processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Giuliana Muzio, Giuseppina Barrera, Stefania Pizzimenti
Summary: PPARs, belonging to the nuclear hormone receptor superfamily, play important roles in regulating lipid and carbohydrate metabolisms, as well as various cell functions and physiological processes. Their ability to modulate antioxidant genes expression and inhibit pro-inflammatory mediators synthesis makes them key regulators in cellular response against oxidative stress.
Review
Pharmacology & Pharmacy
Bianca Seminotti, Mateus Grings, Jerry Vockley, Guilhian Leipnitz
Summary: Inherited metabolic disorders (IMDs) are genetic disorders that disrupt specific metabolic pathways, leading to biochemical, clinical, and pathophysiological consequences. Secondary mitochondrial dysfunction, particularly oxidative phosphorylation impairment and elevated reactive oxygen species, has been found to play a crucial role in many of these disorders. Peroxisomal proliferator-activated receptors (PPARs), a group of nuclear hormone receptors, regulate various cellular functions and processes, including oxidative stress response, inflammation, lipid metabolism, and mitochondrial bioenergetics. Activation of PPARs has shown to improve oxidative phosphorylation and reduce reactive species levels, making pharmacological treatment with PPAR activators a promising approach for IMDs. This review summarizes preclinical and clinical data on the effects of PPARs in IMDs.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Reproductive Biology
Karol Mierzejewski, Aleksandra Kurzynska, Zuzanna Kunicka, Anna Klepacka, Monika Golubska, Iwona Bogacka
Summary: This study investigated the effect of PPARγ agonists on the expression of inflammatory mediators in the porcine endometrium, showing that they can decrease pro-inflammatory markers and increase anti-inflammatory mediators.
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Maki Fujimoto, Hitoshi Higuchi, Yuka Honda-Wakasugi, Saki Miyake, Yukiko Nishioka, Akiko Yabuki-Kawase, Shigeru Maeda, Takuya Miyawaki
Summary: The study investigated the anti-inflammatory mechanism of dexmedetomidine in inhibiting LPS-induced inflammatory responses. It was found that dexmedetomidine inhibits inflammation by activating PPAR gamma or increasing the production of 15d-PGJ2. The results suggest that dexmedetomidine inhibits LPS-induced inflammatory responses by binding to alpha(2) adrenoceptors and activating PPAR gamma.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Haoyang Zou, Yiyao Gong, Haiqing Ye, Cuiping Yuan, Tiezhu Li, Jie Zhang, Li Ren
Summary: This study summarizes the physiological importance and clinical significance of PPARs and reviews the experimental evidence that natural products mediate metabolic syndrome via PPARs. The majority of currently described natural compounds are mild PPAR-selective agonists with therapeutic effects that are equivalent to synthetic medicines but less harmful adverse effects. Conclusion: PPAR agonists can be combined with natural products to treat and prevent metabolic syndrome.
Review
Pharmacology & Pharmacy
Jianjun Gao, Zhaoyan Gu
Summary: Peroxisome proliferator-activated receptors (PPARs), a type of ligand-activated transcription factor, may play an important role in the pathogenesis of kidney disease and could serve as potential therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Article
Nutrition & Dietetics
Nikita Martens, Na Zhan, Gardi Voortman, Frank P. J. Leijten, Connor van Rheenen, Suzanne van Leerdam, Xicheng Geng, Michiel Huybrechts, Hongbing Liu, Johan W. W. Jonker, Folkert Kuipers, Dieter Lutjohann, Tim Vanmierlo, Monique T. T. Mulder
Summary: The nuclear liver X receptors (LXRα/β) and peroxisome proliferator-activated receptors (PPARα/γ) play a role in regulating lipid metabolism and inflammation. The activation of these receptors has neuroprotective effects and may be a potential treatment for neurodegenerative disorders like Alzheimer's Disease (AD). The brown seaweed Sargassum fusiforme contains compounds that activate these receptors and have been shown to prevent disease progression in a mouse model of AD.
Article
Pharmacology & Pharmacy
Ya-Di Zhu, Xiao-Qing Guan, Jing Chen, Sheng Peng, Moshe Finel, Ying-Yuan Zhao, Rui-Min Wang, Hui-Chang Bi, Ming Lei, Dan-Dan Wang, Guang-Bo Ge
Summary: NBIF is identified as a potent natural inducer of UGT1A1, mainly activating and up-regulating PPAR alpha and PPAR gamma to induce UGT1A1 expression. This finding suggests that NBIF could be a promising lead compound for the development of more efficacious UGT1A1 inducers to treat hyperbilirubinaemia and UGT1A1-associated drug toxicities.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Paulina Escandon, Brenda Vasini, Amy E. Whelchel, Sarah E. Nicholas, H. Greg Matlock, Jian-Xing Ma, Dimitrios Karamichos
Summary: PPARs are a family of nuclear receptors that play essential roles in modulating cell differentiation, inflammation, and metabolism, and have been linked to various eye diseases. Studies have shown different subtypes of PPARs have varying effects on ocular homeostasis and potential therapeutic implications for eye diseases, highlighting the need for further research on their role in ocular pathologies.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Oncology
Nasim Dana, Gordon A. Ferns, Reza Nedaeinia, Shaghayegh Haghjooy Javanmard
Summary: Obesity affects tumor development and interacts with leptin and peroxisome proliferator-activated receptors. Studies have shown an association between obesity and various types of cancer, including breast cancer.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Dermatology
Anne Kogge, Christelle Volteau, Melanie Saint-Jean, Lucie Peuvrel, Annabelle Brocard, Anne-Chantal Knol, Jean-Jaques Renaut, Brigitte Dreno, Gaelle Quereux
ACTA DERMATO-VENEREOLOGICA
(2015)
Article
Oncology
Amir Khammari, Jean-Michel Nguyen, Melanie Saint-Jean, Anne-Chantal Knol, Marie-Christine Pandolfino, Gaelle Quereux, Anabelle Brocard, Lucie Peuvrel, Soraya Saiagh, Vincent Bataille, Jean-Marc Limacher, Brigitte Dreno
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2015)
Letter
Medical Laboratory Technology
Marc G. Denis, Anne-Chantal Knol, Sandrine Theoleyre, Audrey Vallee, Brigitte Dreno
CLINICAL CHEMISTRY
(2015)
Article
Immunology
Melanie Saint-Jean, Anne-Chantal Knol, Christelle Volteau, Gaelle Quereux, Lucie Peuvrel, Anabelle Brocard, Marie-Christine Pandolfino, Soraya Saiagh, Jean-Michel Nguyen, Christophe Bedane, Nicole Basset-Seguin, Amir Khammari, Brigitte Dreno
JOURNAL OF IMMUNOLOGY RESEARCH
(2018)
Editorial Material
Dermatology
Brigitte Dreno, Eric Blouin, Dominique Moyse, Isaac Bodokh, Anne Chantal Knol, Amir Khammari
ACTA DERMATO-VENEREOLOGICA
(2014)
Article
Dermatology
Anne-Chantal Knol, Marie-Christine Pandolfino, Audrey Vallee, Frederique Nguyen, Virginie Lella, Amir Khammari, Marc Denis, Anne-Laure Puaux, Brigitte Dreno
EXPERIMENTAL DERMATOLOGY
(2015)
Article
Pathology
A. J. J. Roussel, A. C. Knol, R. J. Bourdeau, V. Bruet
JOURNAL OF COMPARATIVE PATHOLOGY
(2014)
Letter
Dermatology
Melanie Saint-Jean, Gaelle Quereux, Jean-Michel Nguyen, Lucie Peuvrel, Anabelle Brocard, Audrey Vallee, Anne-Chantal Knol, Amir Khammari, Marc G. Denis, Brigitte Dreno
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2014)
Article
Oncology
L. Peuvrel, M. Saint-Jean, G. Quereux, A. Brocard, A. Khammari, A. C. Knol, B. Dreno
JOURNAL OF NEURO-ONCOLOGY
(2014)
Review
Dermatology
Gaelle Quereux, Anabelle Brocard, Melanie Saint-Jean, Lucie Peuvrel, Anne-Chantal Knol, Remy Allix, Amir Khammari, Jean-Jacques Renaut, Brigitte Dreno
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2013)
Article
Oncology
Melanie Saint-Jean, Gaelle Quereux, Man-Michel Nguyen, Lucie Peuvrel, Anabelle Brocard, Audrey Vallee, Anne-Chantal Knol, Amir Khammari, Marc G. Denis, Brigitte Dreno
Article
Multidisciplinary Sciences
Thomas Zuliani, Soraya Saiagh, Anne-Chantal Knol, Julie Esbelin, Brigitte Dreno
Article
Multidisciplinary Sciences
Brigitte Dreno, Mirjana Urosevic-Maiwald, Youn Kim, Joan Guitart, Madeleine Duvic, Olivier Dereure, Amir Khammari, Anne-Chantal Knol, Anna Derbij, Monika Lusky, Isabelle Didillon, Anne-Marie Santoni, Bruce Acres, Vincent Bataille, Marie-Pierre Chenard, Pascal Bleuzen, Jean-Marc Limacher, Reinhard Dummer
Article
Immunology
Amir Khammari, Anne-Chantal Knol, Jean-Michel Nguyen, Celine Bossard, Marc-Guillaume Denis, Marie-Christine Pandolfino, Gaelle Quereux, Sylvain Bercegeay, Brigitte Dreno
JOURNAL OF IMMUNOLOGY RESEARCH
(2014)
Article
Veterinary Sciences
Anne J. J. Roussel, Vincent Bruet, Rosanna Marsella, Anne Chantal Knol, Patrick J. Bourdeau
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
(2015)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)