Article
Chemistry, Medicinal
Luying Chen, Ge Yan, Tomohiko Ohwada
Summary: Diverse biologically active molecules are produced from phospholipids, the constituents of biological membranes. These lipid mediators bind to protein receptors and regulate biological processes through signaling pathways. Dysfunction of this regulatory network may lead to diseases. This article reviews recent progress in drug development targeting related receptors and discusses relevant issues in drug design.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Gang Pei, Joanna Zyla, Lichun He, Pedro Moura-Alves, Heidrun Steinle, Philippe Saikali, Laura Lozza, Natalie Nieuwenhuizen, January Weiner, Hans-Joachim Mollenkopf, Kornelia Ellwanger, Christine Arnold, Mojie Duan, Yulia Dagil, Mikhail Pashenkov, Ivo Gomperts Boneca, Thomas A. Kufer, Anca Dorhoi, Stefan H. E. Kaufmann
Summary: This study revealed the role of NOD1/2 in monitoring cellular homeostasis by sensing the intracellular metabolite S1P, which acts as a novel activator for NOD1/2, and NOD1/2 as molecular hubs that integrate bacterial and metabolic signals.
Article
Endocrinology & Metabolism
Albane le Maire, Martial Rey, Valerie Vivat, Laura Guee, Pauline Blanc, Christian Malosse, Julia Chamot-Rooke, Pierre Germain, William Bourguet
Summary: This study identified two RXR variants, one completely disabled for ligand binding while maintaining other functions intact and another that selectively impairs interaction with natural rexinoids but not with some synthetic ligands. The study also suggested a possible involvement of fatty acids in the weak interaction of RXRs with corepressors.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Faiz-ul Hassan, Asif Nadeem, Zhipeng Li, Maryam Javed, Qingyou Liu, Jahanzaib Azhar, Muhammad Saif-ur Rehman, Kuiqing Cui, Saif Ur Rehman
Summary: PPARs are nuclear receptors that regulate metabolic networks through nutrient-dependent transcriptional activation, but can be disrupted under metabolic stress. Nutrients such as polyunsaturated fatty acids, vitamins, and phytochemicals can modulate PPARs through various mechanisms, ultimately helping to prevent metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alex Zaufel, Sandra M. W. van de Wiel, Lu Yin, Gunter Fauler, Daphne Chien, Xinzhong Dong, John F. Gilmer, Jennifer K. Truong, Paul A. Dawson, Stan F. J. van de Graaf, Peter Fickert, Tarek Moustafa
Summary: Secondary (iso) BAs cooperatively activate FXR in the presence of endogenous BAs, which is important to consider in diseases linked to disturbances in BA enterohepatic cycling; the study shows that UDCA is only effective in the presence of endogenous FXR ligands.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Chemistry, Medicinal
Sreekanth Rajan, Ho Sup Yoon
Summary: Nuclear receptors (NRs) are ligand-induced transcriptional factors that regulate gene expression by binding to ligands. Some ligands form covalent bonds with NRs. Conserved cysteines in specific regions of NRs play a key role in the covalent attachment. These structural insights aid drug discovery efforts targeting NRs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Microbiology
Nicholas Dopkins, Bhavya Singh, Stephanie Michael, Morgan M. O'Mara, Jez L. Marston, Tongyi Fei, Matthew L. Bendall, Douglas F. Nixon
Summary: Transposable elements (TEs) are mobile genomic sequences that constitute a significant portion of the human genome. They can be induced by immunostimulatory cues and play a role in host-microbiota interaction. This study demonstrates that toll-like receptor activation alters the expression of retrotransposons and that reverse transcriptase inhibitor delivery can ameliorate the inflammatory response.
Article
Biochemistry & Molecular Biology
Yaowei Wang, Jessica Perez-Sancho, Matthieu Pierre Platre, Brenda Callebaut, Marija Smokvarska, Karoll Ferrer, Yongming Luo, Trevor M. M. Nolan, Takeo Sato, Wolfgang Busch, Philip N. N. Benfey, Miroslav Kvasnica, Johan M. M. Winne, Emmanuelle M. M. Bayer, Nemanja Vukasinovic, Eugenia Russinova
Summary: Brassinosteroids are important phytohormones for plant growth and adaptation to stress. Our study reveals that plasmodesmata play a role in the short-distance transport of brassinosteroids between neighboring cells. The intracellular brassinosteroid content can modulate plasmodesmata permeability, thereby regulating brassinosteroid biosynthesis and signaling. This work uncovers a new mode of steroid transport in eukaryotes and adds a layer of regulation to brassinosteroid homeostasis in plants.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giulia D'Arrigo, Ida Autiero, Eleonora Gianquinto, Lydia Siragusa, Massimo Baroni, Gabriele Cruciani, Francesca Spyrakis
Summary: Nuclear receptors (NRs) are transcription factors that play an important role in multiple diseases and their intrinsic dynamics make them a challenging target in drug discovery. This study proposes a methodology based on the computation and comparison of protein cavities in NR structures to uncover their dynamic profile. This approach can guide research on NR intrinsic dynamics, aid in selecting reference structures for drug design, and facilitate the identification of alternative binding sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dominik Klaver, Hubert Gander, Gabriele Dobler, Andrea Rahm, Martin Thurnher
Summary: This study reveals how P2Y(11) utilizes IL-1R and canonical signaling pathways to promote the anti-inflammatory and pro-angiogenic properties of human M2 macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Immunology
Kangyi Hu, Zhengya Shang, Xiaorui Yang, Yongjie Zhang, Linzhong Cao
Summary: Bone immunity is the intersection between the skeletal and immune systems, involving various signaling pathways and the interaction between immune cells and bone cells. Macrophages, as key cell types in bone immunity, can polarize into pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages, playing different roles in bone metabolism. Imbalanced polarization of macrophages can lead to immune dysregulation and release of inflammatory factors, affecting bone metabolism and causing diseases such as osteoporosis and rheumatoid arthritis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Environmental Sciences
Pavlina Simeckova, Katerina Pencikova, Ondrej Kovac, Josef Slavik, Martina Parenicova, Jan Vondracek, Miroslav Machala
Summary: The toxicity profiles of six environmentally relevant PAHs were evaluated, revealing their interactions with intracellular receptors and signaling pathways, as well as their impact on cellular metabolism, stress, and genotoxicity markers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Immunology
Pailin Chiaranunt, Siu Ling Tai, Louis Ngai, Arthur Mortha
Summary: Intestinal macrophages, the largest macrophage population in the body, not only play a role in immunity but also have crucial non-immune functions. Recent research suggests that the functional diversity of macrophages in the gut goes beyond classical immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xingyu Wang, Lan Zhou
Summary: Skeletal muscle is crucial for physical activity, energy metabolism, and temperature maintenance. Muscle stem cells, satellite cells, play a vital role in maintaining homeostasis and promoting muscle regeneration. Intramuscular macrophages, functionally diverse, regulate the quiescence, activation, and differentiation of satellite cells. Aberrant activation of intramuscular macrophages, often triggered by altered muscle microenvironment, disrupts muscle homeostasis and regenerative repair. Manipulating the functional activation of macrophages has potential therapeutic implications for muscle diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Siyu Wu, Jiayi Ma, Jun Liu, Chun Liu, Su Ni, Ting Dai, Yan Wang, Yiping Weng, Hongbin Zhao, Dong Zhou, Xiubo Zhao
Summary: In this study, a nanostructured scaffold loaded with telmisartan was developed to modulate the immune response and promote bone healing. The results showed that telmisartan-loaded scaffolds exhibited anti-inflammatory activity and enhanced bone regeneration by regulating macrophage polarization.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Endocrinology & Metabolism
Madhavi Derangula, Kalpana Panati, Venkata R. Narala
Summary: BCA can alleviate inflammation in a murine model of asthma by activating PPAR gamma, showing promise for the treatment of asthma in humans.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Article
Chemistry, Inorganic & Nuclear
Vydyanath R. Narasimha, T. Sree Latha, Reddanna Pallu, Kalpana Panati, Venkata Ramireddy Narala
Summary: The green synthesis of silver nanoparticles (AgNPs) using Eucalyptus leaf extract was shown to have potential anticancer activity with dual inhibitory action on COX-2 and NF-κB expression. These AgNPs exhibited dose-dependent cytotoxic effects against colorectal cancer cells (HCT116), inhibiting cell proliferation and colony formation, and increasing ROS production.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Fisheries
Eakapol Wangkahart, Suriyet Wachiraamonloed, Po-Tsang Lee, Parasuraman Aiya Subramani, Zhitao Qi, Bei Wang
Summary: The study showed that supplementing Aegle marmelos fruit extract in the diet of Nile tilapia significantly promoted growth, enhanced antioxidant capacity and immune response. Furthermore, it provided protection against Streptococcus agalactiae infection.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Eakapol Wangkahart, Brecht Bruneel, Anut Chantiratikul, Matthijs de Jong, Noppakun Pakdeenarong, Parasuraman Aiya Subramani
Summary: This study investigated the effects of sources and levels of selenium on juvenile Nile tilapia. The results showed that supplementing the diet with 1.0 mg/kg of organic selenium improved growth performance, reduced cholesterol levels, and enhanced antioxidant enzyme activities and disease resistance in the fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Saied A. Aboushanab, Ali H. El-Far, Venkata Ramireddy Narala, Rokia F. Ragab, Elena G. Kovaleva
Summary: Isoflavones, as natural compounds, have potential anti-inflammatory and antioxidant effects in the treatment of ALI and can positively impact the disease through multiple pathways. While research scope is limited, there is potential to fill gaps in understanding the protective roles of isoflavones in ALI, especially in terms of antioxidant potential, inhibition of inflammatory pathways, and associated molecular mechanisms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Parasuraman Aiya Subramani, Firdose Begum Shaik, R. Dinakaran Michael, Kalpana Panati, Venkata Ramireddy Narala
Summary: This study establishes thiamine as a PPAR-gamma ligand through molecular docking and dynamics simulations. In vitro assays show that thiamine induces adipogenesis and upregulates the expression of PPAR-gamma and AP-2 genes. Animal studies and clinical trials are necessary to confirm these findings.
LETTERS IN DRUG DESIGN & DISCOVERY
(2022)
Article
Pharmacology & Pharmacy
Sahebgowda Sidramagowda Patil, Ramani Soundararajan, Jutaro Fukumoto, Mason Breitzig, Helena Hernandez-Cuervo, Matthew Alleyn, Muling Lin, Venkata Ramireddy Narala, Richard Lockey, Narasaiah Kolliputi, Lakshmi Galam
Summary: High concentrations of supplementary oxygen are used to treat acute lung injury and acute respiratory distress syndrome, but prolonged exposure can lead to mitochondrial damage and protein misfolding in the endoplasmic reticulum. Akap1 plays a critical role in maintaining mitochondrial homeostasis, and its deficiency exacerbates lung injury. Deleting Akap1 increases ER stress in response to hyperoxia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Suresh Yarrappagaari, Lavanya Thopireddy, Srinivasulu Cheemanapalli, Venkata Rami Reddy Narala, Kakarla Chandra Mohan, Rajeswara Reddy Saddala
Summary: This study evaluated the antihyperglycemic effects of different extracts of Cleome viscosa on diabetes. The results showed that the methanolic extract (MeCV) had strong effects on enzymatic and non-enzymatic activities, and contained rich polyphenolic compounds.
PHARMACOGNOSY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ramani Soundararajan, Helena Hernandez-Cuervo, Timothy M. Stearns, Anthony J. Griswold, Sahebgowda Sidramagowda Patil, Jutaro Fukumoto, Venkata Ramireddy Narala, Lakshmi Galam, Richard Lockey, Narasaiah Kolliputi
Summary: This study revealed the mechanisms underlying the progression of acute lung injury using transcriptome analysis. The overexpression of AKAP1 and the modulation of Drp1 phosphorylation were identified as important therapeutic strategies for acute lung injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Madhavi Derangula, Kumarla Kaluva Ruhinaz, Kalpana Panati, Parasuraman Aiya Subramani, Venkatramana Reddy Arva Tatireddigari, Venkata Ramireddy Narala
Summary: Immunologists have found that while short-term inflammation can be beneficial, long-term chronic inflammation can be damaging. Obesity, type 2 diabetes, and cancer are now considered to be inflammatory diseases. The nuclear transcription factor PPAR-γ is involved in inflammation and obesity, and PPAR-γ agonists have been used to treat disorders such as obesity and T2D. However, the biochemical features and potential adverse effects of these agonists are not fully understood, leading to controversy. This review aims to summarize the physiochemical properties and anti-inflammatory actions of natural PPAR-γ ligands.
NATURAL PRODUCTS JOURNAL
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Fisheries
Sekaran Kalaivani Priyadarshini, Monica Murugesan, R. Dinakaran Michael, Parasuraman Aiya Subramani, Priyatharsini Rajendran
Summary: This study investigated the immunomodulatory effects of orally administered terpenoids and phenol fraction (TPF) from Padina gymnospora in common carp. The results showed that oral TPF administration significantly enhanced nonspecific immune responses and upregulated the expression of immune genes. TPF also exhibited significant protection against experimental infection in carp.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Kalpana Panati, Lokesh Timmana, Venkatramana A. T. Reddy, Rajeswara Reddy Saddala, Venkata Ramireddy Narala
Summary: This review discusses the characteristics of the causative agent of COVID-19, its transmission, and pathological findings. SARS-CoV-2 is a variant of SARS-CoV and MERS-CoV, with higher confirmed cases and death toll. Current treatment is based on symptoms similar to SARS-CoV, and further research is needed to understand the disease through in vivo and ex vivo studies.
EURASIAN JOURNAL OF MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Avik Sarkar, Kalpana Panati, Venkata Ramireddy Narala
Summary: Precise pre-mRNA processing, including alternative splicing, is crucial for protein translation in eukaryotes. Both point mutations and synonymous mutations can affect the splicing process, with the latter influencing gene expression through various mechanisms. Different cis-acting elements and trans-acting splicing factors regulate splicing, and synonymous mutations in these elements can change the binding pattern of splicing factors, leading to aberrant splicing and the development of diseases.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
