PPARγ signaling and metabolism: the good, the bad and the future

Modulating peroxisome proliferator–activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects

(2012) Robert S. Rosenson et al.   AMERICAN HEART JOURNAL

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis

(2012) Kai Sun et al.   CELL RESEARCH

Pioglitazone and risk of bladder cancer among diabetic patients in France: a population-based cohort study

(2012) A. Neumann et al.   DIABETOLOGIA

Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials

(2012) G. Musso et al.   DIABETOLOGIA

Thiazolidinedione safety

(2012) Jacqueline Kung et al.   Expert Opinion On Drug Safety

Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders

(2012) Yu-Chang Chen et al.   MOLECULAR NEUROBIOLOGY

A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

(2012) Johan W. Jonker et al.   NATURE

Targeted estrogen delivery reverses the metabolic syndrome

(2012) Brian Finan et al.   NATURE MEDICINE

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

(2012) Aurélien A. Sérandour et al.   NUCLEIC ACIDS RESEARCH

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor  

(2012) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARs: Fatty acid sensors controlling metabolism

(2012) Lars la Cour Poulsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism

(2012) Travis S. Hughes et al.   STRUCTURE

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Thiazolidinediones and PPARγ agonists: time for a reassessment

(2012) Bertrand Cariou et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study

(2012) L. Azoulay et al.   BMJ-British Medical Journal

Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites

(2011) Søren F Schmidt et al.   BMC GENOMICS

Thiazolidinediones Regulate Adipose Lineage Dynamics

(2011) Wei Tang et al.   Cell Metabolism

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

PPARs and Lipid Ligands in Inflammation and Metabolism

(2011) Gregory S. Harmon et al.   CHEMICAL REVIEWS

Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis

(2011) Rasmus Siersbaek et al.   EMBO JOURNAL

Epigenetic codes of PPARγ in metabolic disease

(2011) Shigeki Sugii et al.   FEBS LETTERS

High Glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling

(2011) Amar B. Singh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of PPARg2 transcription factor in thiazolidinedione-induced insulin sensitization

(2011) Neha Saraf et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Brain PPAR-γ promotes obesity and is required for the insulin–sensitizing effect of thiazolidinediones

(2011) Min Lu et al.   NATURE MEDICINE

A role for central nervous system PPAR-γ in the regulation of energy balance

(2011) Karen K Ryan et al.   NATURE MEDICINE

Thiazolidinediones on PPARγ: The Roles in Bone Remodeling

(2011) Wei Wei et al.   PPAR Research

Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome

(2011) Michele Vacca et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

PPAR-γ Agonism for Cardiovascular and Renal Protection

(2010) Pantelis A. Sarafidis et al.   Cardiovascular Therapeutics

The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

(2010) Jan Nedergaard et al.   Cell Metabolism

Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes

(2010) R. Rabøl et al.   DIABETES OBESITY & METABOLISM

STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

(2010) Attila Szanto et al.   IMMUNITY

Risk of Acute Myocardial Infarction, Stroke, Heart Failure, and Death in Elderly Medicare Patients Treated With Rosiglitazone or Pioglitazone

(2010) David J. Graham et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans

(2010) Bruno Lefebvre et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor   Function in Adipocytes and Macrophages

(2010) M. I. Lefterova et al.   MOLECULAR AND CELLULAR BIOLOGY

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Next-generation genomics: an integrative approach

(2010) R. David Hawkins et al.   NATURE REVIEWS GENETICS

PPAR-γSignaling Crosstalk in Mesenchymal Stem Cells

(2010) Ichiro Takada et al.   PPAR Research

Fibroblast growth factor 21: from pharmacology to physiology

(2009) Steven A Kliewer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation

(2009) Linda Slanec Higgins et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Thiazolidinediones may contribute to the intramyocardial lipid accumulation in diabetic myocardium: effects on cardiac function

(2009) R Marfella et al.   HEART

Adipocyte-specific Expression of Murine Resistin Is Mediated by Synergism between Peroxisome Proliferator-activated Receptor γ and CCAAT/Enhancer-binding Proteins

(2009) Takuya Tomaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranslational Modifications of PPAR-γ: Fine-tuning the Metabolic Master Regulator

(2009) Olivier van Beekum et al.   Obesity

De-Novo Identification of PPARγ/RXR Binding Sites and Direct Targets during Adipogenesis

(2009) Mohamed Sabry Hamza et al.   PLoS One

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

(2009) Shigeki Sugii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The skinny on fat: lipolysis and fatty acid utilization in adipocytes

(2009) Maryam Ahmadian et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effects of pioglitazone on major adverse cardiovascular events in high-risk patients with type 2 diabetes: Results from PROspective pioglitAzone Clinical Trial In macro Vascular Events (PROactive 10)

(2008) Robert Wilcox et al.   AMERICAN HEART JOURNAL

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Expression of Peroxisome Proliferator-Activated Receptor-γ in Key Neuronal Subsets Regulating Glucose Metabolism and Energy Homeostasis

(2008) David A. Sarruf et al.   ENDOCRINOLOGY

PPAR  and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

(2008) M. I. Lefterova et al.   GENES & DEVELOPMENT

AMPK: a key regulator of energy balance in the single cell and the whole organism

(2008) D G Hardie   INTERNATIONAL JOURNAL OF OBESITY

In Vivoandin VitroStudies of a Functional Peroxisome Proliferator-activated Receptor γ Response Element in the Mousepdx-1Promoter

(2008) Dhananjay Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor-α Regulates Cyclin-dependent Kinase 5 Activity during Pain Signaling through Transcriptional Activation of p35

(2008) Elias Utreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE

Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist

(2008) L. E. Tavera-Mendoza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice

(2008) Yue-Min Nan et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

White Fat Progenitor Cells Reside in the Adipose Vasculature

(2008) W. Tang et al.   SCIENCE

Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease

(2008) Eric R Kallwitz et al.   WORLD JOURNAL OF GASTROENTEROLOGY