Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1)

Syntheses of diacyltanshinol derivatives and their suppressive effects on macrophage foam cell formation by reducing oxidized LDL uptake

(2013) Xi Cheng et al.   BIOORGANIC CHEMISTRY

The Concise Guide to PHARMACOLOGY 2013/14: Nuclear Hormone Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protective effect of cryptotanshinone on lipopolysaccharide-induced acute lung injury in mice

(2013) Ying Tang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tanshinone IIA and Cryptotanshinone Prevent Mitochondrial Dysfunction in Hypoxia-Induced H9c2 Cells: Association to Mitochondrial ROS, Intracellular Nitric Oxide, and Calcium Levels

(2013) Hyou-Ju Jin et al.   Evidence-based Complementary and Alternative Medicine

Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans

(2013) Peter Libby et al.   IMMUNITY

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1

(2013) Zhiping Liu et al.   JOURNAL OF LIPID RESEARCH

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Sirtuin 6 protects cardiomyocytes from hypertrophyin vitrovia inhibition of NF-κB-dependent transcriptional activity

(2012) Shan-Shan Yu et al.   BRITISH JOURNAL OF PHARMACOLOGY

LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

(2012) Suowen Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tanshinone II-A: new perspectives for old remedies

(2012) Suowen Xu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation

(2012) Suowen Xu et al.   Translational Research

Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet

(2011) Suowen Xu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cardiovascular actions and therapeutic potential of tanshinone IIA

(2011) Si Gao et al.   ATHEROSCLEROSIS

Oxidized LDL, LOX-1 and Atherosclerosis

(2011) Sona Mitra et al.   CARDIOVASCULAR DRUGS AND THERAPY

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress

(2011) Wenying Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

(2011) Christian Besler et al.   JOURNAL OF CLINICAL INVESTIGATION

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Cryptotanshinione Inhibits β-Amyloid Aggregation and Protects Damage from β-Amyloid in SH-SY5Y Cells

(2011) Zhengrong Mei et al.   NEUROCHEMICAL RESEARCH

Cryptotanshinone AttenuatesIn VitrooxLDL-Induced Pre-Lesional Atherosclerotic Events

(2011) Kok-Pian Ang et al.   PLANTA MEDICA

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cryptotanshinone Inhibits Cancer Cell Proliferation by Suppressing Mammalian Target of Rapamycin-Mediated Cyclin D1 Expression and Rb Phosphorylation

(2010) W. Chen et al.   Cancer Prevention Research

Overexpression of scavenger receptor LOX-1 in endothelial cells promotes atherogenesis in the ApoE−/− mouse model

(2010) Stephen J. White et al.   CARDIOVASCULAR PATHOLOGY

Tanshinone IIA attenuates atherosclerosis in ApoE−/− mice through down-regulation of scavenger receptor expression

(2010) Fu-Tian Tang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cryptotanshinone Suppressed Inflammatory Cytokines Secretion in RAW264.7 Macrophages through Inhibition of the NF-κB and MAPK Signaling Pathways

(2010) Shu Tang et al.   INFLAMMATION

Intracellular Signaling of LOX-1 in Endothelial Cell Apoptosis

(2009) Dayuan Li et al.   CIRCULATION RESEARCH

Development of an optimized protocol for primary culture of smooth muscle cells from rat thoracic aortas

(2009) Suowen Xu et al.   CYTOTECHNOLOGY

Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-α-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo

(2009) Yong Chun Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro

(2009) Zhengrong Mei et al.   NEUROSCIENCE LETTERS

Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge

(2008) Su Jin Jeon et al.   ARCHIVES OF PHARMACAL RESEARCH

Transient Increase in Plasma Oxidized LDL During the Progression of Atherosclerosis in Apolipoprotein E Knockout Mice

(2008) Rina Kato et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells

(2008) D.-S. Shin et al.   CANCER RESEARCH

Differential roles of PKCα and PKCɛ in controlling the gene expression of Nox4 in human endothelial cells

(2008) Hui Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacokinetic characterization of hydroxylpropyl-β-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza)

(2008) Y. Pan et al.   XENOBIOTICA

Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion

(2007) Jing-Yan Han et al.   PHARMACOLOGY & THERAPEUTICS