LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

LOX-1

(2012) Tatsuya Sawamura et al.   CURRENT OPINION IN LIPIDOLOGY

Berberine-induced inhibition of adipocyte enhancer-binding protein 1 attenuates oxidized low-density lipoprotein accumulation and foam cell formation in phorbol 12-myristate 13-acetate-induced macrophages

(2012) Zhouqing Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Site-specific N-glycosylation identification of recombinant human lectin-like oxidized low density lipoprotein receptor-1 (LOX-1)

(2012) Yifan Qian et al.   GLYCOCONJUGATE JOURNAL

Olmesartan Attenuates the Impairment of Endothelial Cells Induced by Oxidized Low Density Lipoprotein through Downregulating Expression of LOX-1

(2012) Hua Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Advanced Glycation End Products on Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 Expression in Endothelial Cells

(2012) Sammy WM Shiu et al.   Journal of Atherosclerosis and Thrombosis

Scavenger Receptors in Human Airway Epithelial Cells: Role in Response to Double-Stranded RNA

(2012) Audrey Dieudonné et al.   PLoS One

Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation

(2012) Suowen Xu et al.   Translational Research

Oxidative Stress and Lectin-Like Ox-LDL-Receptor LOX-1 in Atherogenesis and Tumorigenesis

(2011) Jingjun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet

(2011) Suowen Xu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Oxidized Low-Density Lipoprotein Activates p66 Shc via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1, Protein Kinase C-β, and c-Jun N-Terminal Kinase Kinase in Human Endothelial Cells

(2011) Yi Shi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cardiovascular actions and therapeutic potential of tanshinone IIA

(2011) Si Gao et al.   ATHEROSCLEROSIS

LOX-1: A New Target for Therapy for Cardiovascular Diseases

(2011) Jawahar L. Mehta et al.   CARDIOVASCULAR DRUGS AND THERAPY

The Discovery of LOX-1, its Ligands and Clinical Significance

(2011) Ryo Yoshimoto et al.   CARDIOVASCULAR DRUGS AND THERAPY

Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by LOX-1 ligand activity in healthy men

(2011) Kagehiro Uchida et al.   CLINICA CHIMICA ACTA

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

(2011) Christian Besler et al.   JOURNAL OF CLINICAL INVESTIGATION

CRP enhances soluble LOX-1 release from macrophages by activating TNF-α converting enzyme

(2011) Xue Qiang Zhao et al.   JOURNAL OF LIPID RESEARCH

Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis

(2011) Peter J. Little et al.   PHARMACOLOGY & THERAPEUTICS

Oxidized LDL Receptor 1 (OLR1) as a Possible Link between Obesity, Dyslipidemia and Cancer

(2011) Magomed Khaidakov et al.   PLoS One

Potential Involvement of LOX-1 in Functional Consequences of Endothelial Senescence

(2011) Magomed Khaidakov et al.   PLoS One

Effects of Berberine on Expression of LOX-1 and SR-BI in Human Macrophage-Derived Foam Cells Induced by ox-LDL

(2010) Siming Guan et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) by 15-lipoxygenase-modified LDL in endothelial cells

(2010) Angela Pirillo et al.   ATHEROSCLEROSIS

OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling

(2010) Sungwoo Ryoo et al.   ATHEROSCLEROSIS

Overexpression of scavenger receptor LOX-1 in endothelial cells promotes atherogenesis in the ApoE−/− mouse model

(2010) Stephen J. White et al.   CARDIOVASCULAR PATHOLOGY

Smad linker region phosphorylation in the regulation of extracellular matrix synthesis

(2010) Micah L. Burch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Predicts Prognosis After Acute Coronary Syndrome

(2010) Noriaki Kume et al.   CIRCULATION JOURNAL

LOX Index, a Novel Predictive Biochemical Marker for Coronary Heart Disease and Stroke

(2010) N. Inoue et al.   CLINICAL CHEMISTRY

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

(2010) Sokrates Stein et al.   EUROPEAN HEART JOURNAL

Ox-LDL-induced LOX-1 expression in vascular smooth muscle cells: role of reactive oxygen species

(2010) Yiyi Sun et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling

(2010) Hsiu-Chung Ou et al.   JOURNAL OF APPLIED PHYSIOLOGY

Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a sensitive and specific biomarker for acute coronary syndrome—Comparison with other biomarkers

(2010) Noriaki Kume et al.   Journal of Cardiology

Resveratrol Attenuates Oxidized LDL-Evoked Lox-1 Signaling and Consequently Protects against Apoptotic Insults to Cerebrovascular Endothelial Cells

(2010) Huai-Chia Chang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pitavastatin Reduces Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands in Hypercholesterolemic Humans

(2010) Tetsuya Matsumoto et al.   LIPIDS

Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cells

(2009) Junichi Ishiyama et al.   ATHEROSCLEROSIS

LOX-1 as a natural IFN- -mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells

(2009) S. Parlato et al.   BLOOD

Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet

(2009) Birgit Eichhorn et al.   CARDIOVASCULAR RESEARCH

LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells

(2009) Koichi Sugimoto et al.   CARDIOVASCULAR RESEARCH

LOX-1

(2009) Sayoko Ogura et al.   CIRCULATION JOURNAL

Mediation of Electronegative Low-Density Lipoprotein Signaling by LOX-1

(2009) Jonathan Lu et al.   CIRCULATION RESEARCH

Intracellular Signaling of LOX-1 in Endothelial Cell Apoptosis

(2009) Dayuan Li et al.   CIRCULATION RESEARCH

Cardiac Hypertrophy During Hypercholesterolemia and Its Amelioration With Rosuvastatin and Amlodipine

(2009) Bum-Yong Kang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma

(2009) David F. Schaeffer et al.   JOURNAL OF LIPID RESEARCH

Glycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus

(2008) Sammy W.M. Shiu et al.   ATHEROSCLEROSIS

Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1)

(2008) Hirokazu Mitsuoka et al.   ATHEROSCLEROSIS

The oral anti-diabetic agent, gliclazide, inhibits oxidized LDL-mediated LOX-1 expression, metalloproteinase-9 secretion and apoptosis in human aortic endothelial cells

(2008) Ling Li et al.   ATHEROSCLEROSIS

LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet

(2008) C. Hu et al.   CARDIOVASCULAR RESEARCH

Impact of Plasma Oxidized Low-Density Lipoprotein Removal on Atherosclerosis

(2008) Yasushi Ishigaki et al.   CIRCULATION

Hyperelongated biglycan: the surreptitious initiator of atherosclerosis

(2008) Peter J Little et al.   CURRENT OPINION IN LIPIDOLOGY

Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levels

(2008) Tina E. Brinkley et al.   EXPERIMENTAL PHYSIOLOGY

Modulation of Angiotensin II–Mediated Hypertension and Cardiac Remodeling by Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Deletion

(2008) Changping Hu et al.   HYPERTENSION

Regulation of TGFβ1-mediated Collagen Formation by LOX-1

(2008) Changping Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LOX-1 Receptor Blockade Abrogates oxLDL-induced Oxidative DNA Damage and Prevents Activation of the Transcriptional Repressor Oct-1 in Human Coronary Arterial Endothelium

(2008) Thomas Thum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 are Associated with Inflammatory Markers

(2008) Valter Lubrano et al.   LIPIDS