The MYCN Protein in Health and Disease

Bromodomain Histone Readers and Cancer

(2017) Abhinav K Jain et al.   JOURNAL OF MOLECULAR BIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Bromodomains: Structure, function and pharmacology of inhibition

(2016) Elena Ferri et al.   BIOCHEMICAL PHARMACOLOGY

Parsing Myc Paralogs in Oncogenesis

(2016) Haritha Mathsyaraja et al.   CANCER CELL

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer

(2016) Etienne Dardenne et al.   CANCER CELL

Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination

(2016) Jungoh Ham et al.   CANCER CELL

p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance

(2016) O. Yogev et al.   CANCER RESEARCH

Childhood medulloblastoma

(2016) Maura Massimino et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Constitutional 560.49 kb chromosome 2p24.3 duplication including the MYCN gene identified by SNP chromosome microarray analysis in a child with multiple congenital anomalies and bilateral Wilms tumor

(2016) Mark A. Micale et al.   European Journal of Medical Genetics

Heterogeneity ofMYCNamplification in neuroblastoma at diagnosis, treatment, relapse, and metastasis

(2016) Paula Marrano et al.   GENES CHROMOSOMES & CANCER

A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long-term progression-free survival of patients with resistant neuroblastoma

(2016) Brian H. Kushner et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial

(2016) Steven G. DuBois et al.   JOURNAL OF CLINICAL ONCOLOGY

A Rapid and Sensitive Next-Generation Sequencing Method to Detect RB1 Mutations Improves Care for Retinoblastoma Patients and Their Families

(2016) Wenhui L. Li et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis

(2016) Daniel R. Carter et al.   Molecular Oncology

A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

(2016) Daniel Dauch et al.   NATURE MEDICINE

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

(2016) Colin C. Pritchard et al.   NEW ENGLAND JOURNAL OF MEDICINE

MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation

(2016) D-L Qi et al.   ONCOGENE

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

(2016) Mark W. Richards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Overexpression of MYCN promotes proliferation of non-small cell lung cancer

(2016) Kun Liu et al.   TUMOR BIOLOGY

Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors

(2016) Lynsey Vaughan et al.   Oncotarget

Regulation of Nuclear Hormone Receptors by MYCN-Driven miRNAs Impacts Neural Differentiation and Survival in Neuroblastoma Patients

(2016) Diogo Ribeiro et al.   Cell Reports

Neuroblastoma

(2016) Katherine K. Matthay et al.   Nature Reviews Disease Primers

Targeting Survivin Enhances Chemosensitivity in Retinoblastoma Cells and Orthotopic Tumors

(2016) Angela Ferrario et al.   PLoS One

Neurobehavioral Alterations in a Genetic Murine Model of Feingold Syndrome 2

(2015) E. Fiori et al.   BEHAVIOR GENETICS

Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis

(2015) Daniel Diolaiti et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Impact of MYC in regulation of tumor cell metabolism

(2015) Therese Wahlström et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Small-molecule inhibitors of the Myc oncoprotein

(2015) Steven Fletcher et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children’s Oncology Group study

(2015) L L Wang et al.   BRITISH JOURNAL OF CANCER

Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis

(2015) Blake R Wilde et al.   BRITISH JOURNAL OF CANCER

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

(2015) Patrick A. Carroll et al.   CANCER CELL

Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice

(2015) Alexander Stermann et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma

(2015) Abdelkader Selmi et al.   CANCER LETTERS

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress

(2015) M Petroni et al.   CELL DEATH AND DIFFERENTIATION

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition

(2015) A. Henssen et al.   CLINICAL CANCER RESEARCH

MYC as Therapeutic Target for Embryonal Tumors: Potential and Challenges

(2015) Tarek Shalaby et al.   CURRENT CANCER DRUG TARGETS

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Neuroblastoma

(2015) Meredith S. Irwin et al.   PEDIATRIC CLINICS OF NORTH AMERICA

A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma

(2015) Giselle L. Saulnier Sholler et al.   PLoS One

PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer

(2015) Ana Bosch et al.   Science Translational Medicine

Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis

(2015) S Nicolai et al.   Cell Death & Disease

MYCN concurrence with SAHA-induced cell death in human neuroblastoma cells

(2015) Constanza Cortés et al.   CELLULAR ONCOLOGY

Identification of GALNT14 as a novel neuroblastoma predisposition gene

(2015) Marilena De Mariano et al.   Oncotarget

Multiple mechanisms of MYCN dysregulation in Wilms tumour

(2015) Richard D. Williams et al.   Oncotarget

In Vivo Single-Cell Detection of Metabolic Oscillations in Stem Cells

(2015) Chiara Stringari et al.   Cell Reports

Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer

(2015) Tene Aneka Cage et al.   Frontiers in Oncology

Glutamine, Glucose and other Fuels for Cancer

(2015) Maria Ruiz-Perez et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular and In Vivo Characterization of Cancer-Propagating Cells Derived from MYCN-Dependent Medulloblastoma

(2015) Zai Ahmad et al.   PLoS One

Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis

(2015) Bret C. Mobley et al.   PLoS One

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia

(2015) Annalisa Astolfi et al.   Oncotarget

Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer

(2015) Juan Miguel Mosquera et al.   NEOPLASIA

Neural crest cells: From developmental biology to clinical interventions

(2014) Parinya Noisa et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming

(2014) B. M. M. Zwaans et al.   Disease Models & Mechanisms

Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics

(2014) Bing-Jia Chen et al.   International Journal of Biological Sciences

Identification and Pharmacological Inactivation of the MYCN Gene Network as a Therapeutic Strategy for Neuroblastic Tumor Cells

(2014) Olesya Chayka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF4 and N-Myc coordinate glutamine metabolism inMYCN-amplified neuroblastoma cells through ASCT2 activation

(2014) Ping Ren et al.   JOURNAL OF PATHOLOGY

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

(2014) Junwei Shi et al.   MOLECULAR CELL

Mechanisms of neuroblastoma regression

(2014) Garrett M. Brodeur et al.   Nature Reviews Clinical Oncology

MYCN amplification predicts poor outcome for patients with supratentorial primitive neuroectodermal tumors of the central nervous system

(2014) Marco Gessi et al.   NEURO-ONCOLOGY

Targeted treatment for sonic hedgehog-dependent medulloblastoma

(2014) M. W. Kieran   NEURO-ONCOLOGY

A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies

(2014) K Althoff et al.   ONCOGENE

Targeting of the MYCN Protein with Small Molecule c-MYC Inhibitors

(2014) Inga Müller et al.   PLoS One

Sunitinib Suppress Neuroblastoma Growth through Degradation of MYCN and Inhibition of Angiogenesis

(2014) Raul Calero et al.   PLoS One

Exploration of the selective recognition of the G-quadruplex in the N-myc oncogene by electrospray ionization mass spectrometry

(2014) Fangyuan Li et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

MYCN gene expression is required for the onset of the differentiation programme in neuroblastoma cells

(2014) L Guglielmi et al.   Cell Death & Disease

An Overview of MYC and Its Interactome

(2014) M. Conacci-Sorrell et al.   Cold Spring Harbor Perspectives in Medicine

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

Solution equilibria of cytosine- and guanine-rich sequences near the promoter region of the n-myc gene that contain stable hairpins within lateral loops

(2013) Sanae Benabou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

(2013) Markus Brockmann et al.   CANCER CELL

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis

(2013) M Kracikova et al.   CELL DEATH AND DIFFERENTIATION

Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma

(2013) J. Rader et al.   CLINICAL CANCER RESEARCH

Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma

(2013) Carmelle Romain et al.   JOURNAL OF PEDIATRIC SURGERY

Role of MYCN in retinoblastoma

(2013) Dean W Felsher   LANCET ONCOLOGY

Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies

(2013) Diane E Rushlow et al.   LANCET ONCOLOGY

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sympathetic neurons and chromaffin cells share a common progenitor in the neural crest in vivo

(2013) Stella Shtukmaster et al.   Neural Development

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

(2013) Anastasia Wyce et al.   PLoS One

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

(2013) H. Zirath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell cycle control across the eukaryotic kingdom

(2013) Hirofumi Harashima et al.   TRENDS IN CELL BIOLOGY

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

(2013) Alexandre Puissant et al.   Cancer Discovery

MYCN-mediated transcriptional repression in neuroblastoma: the other side of the coin

(2013) Samuele Gherardi et al.   Frontiers in Oncology

Mitochondrial Dynamics and Motility Inside Living Vascular Endothelial Cells: Role of Bioenergetics

(2012) Randy J. Giedt et al.   ANNALS OF BIOMEDICAL ENGINEERING

Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition

(2012) Anne R. Diers et al.   BIOCHEMICAL JOURNAL

Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC

(2012) Fredrik J. Swartling et al.   CANCER CELL

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

Development of treatment strategies for advanced neuroblastoma

(2012) Junichi Hara   International Journal of Clinical Oncology

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

(2012) Martin Peifer et al.   NATURE GENETICS

BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery

(2012) J Hagenbuchner et al.   ONCOGENE

Role of MXD3 in Proliferation of DAOY Human Medulloblastoma Cells

(2012) Gustavo A. Barisone et al.   PLoS One

A framework for identification of actionable cancer genome dependencies in small cell lung cancer

(2012) M. L. Sos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term Follow-up of the “Wait and See” Approach to Localized Perinatal Adrenal Neuroblastoma

(2012) Denis Andrew Cozzi et al.   WORLD JOURNAL OF SURGERY

Biological and clinical heterogeneity of MYCN-amplified medulloblastoma

(2011) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress

(2011) X Liu et al.   CELL DEATH AND DIFFERENTIATION

Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

(2011) R. Tonelli et al.   CLINICAL CANCER RESEARCH

Dissection of the MYCN locus in Feingold syndrome and isolated oesophageal atresia

(2011) Marie Cognet et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Copy number defects of G1-Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis

(2011) Jan J. Molenaar et al.   GENES CHROMOSOMES & CANCER

Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in wilms tumor

(2011) Richard D. Williams et al.   GENES CHROMOSOMES & CANCER

Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo

(2011) Lova Segerström et al.   INTERNATIONAL JOURNAL OF CANCER

MYCN/MYC-mediated drug resistance mechanisms in neuroblastoma

(2011) S. Gogolin et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood-Brain Barrier

(2011) A. Rohner et al.   MOLECULAR CANCER THERAPEUTICS

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

(2011) K. A. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetically engineered murine models – Contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma

(2011) Louis Chesler et al.   SEMINARS IN CANCER BIOLOGY

Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

(2011) H. Beltran et al.   Cancer Discovery

MYCN oncoprotein targets and their therapeutic potential

(2010) Emma Bell et al.   CANCER LETTERS

p53 Is a Direct Transcriptional Target of MYCN in Neuroblastoma

(2010) L. Chen et al.   CANCER RESEARCH

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells

(2010) Keriayn N. Smith et al.   Cell Stem Cell

Subtype-Specific FBXW7 Mutation and MYCN Copy Number Gain in Wilms' Tumor

(2010) R. D. Williams et al.   CLINICAL CANCER RESEARCH

Nitric Oxide Control of MYCN Expression and Multi Drug Resistance Genes in Tumours of Neural Origin

(2010) Antonio Porro et al.   CURRENT PHARMACEUTICAL DESIGN

The dorsal neural tube: A dynamic setting for cell fate decisions

(2010) Shlomo Krispin et al.   Developmental Neurobiology

myc maintains embryonic stem cell pluripotency and self-renewal

(2010) Natalia V. Varlakhanova et al.   DIFFERENTIATION

In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization

(2010) D. M. Clausen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

(2010) Li Ma et al.   NATURE CELL BIOLOGY

MYCN Promotes the Expansion of Phox2B-Positive Neuronal Progenitors to Drive Neuroblastoma Development

(2009) Goleeta Alam et al.   AMERICAN JOURNAL OF PATHOLOGY

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

(2009) Tobias Otto et al.   CANCER CELL

Inactivation of p53 and amplification of MYCN gene in a terminal lymphoblastic relapse in a chronic lymphocytic leukemia patient

(2009) Katerina Stano-Kozubik et al.   CANCER GENETICS AND CYTOGENETICS

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

High level MycN expression in non-MYCN amplified neuroblastoma is induced by the combination treatment nutlin-3 and doxorubicin and enhances chemosensitivity

(2009) Peirce   ONCOLOGY REPORTS

N-Myc Regulates Expression of Pluripotency Genes in Neuroblastoma Including lif, klf2, klf4, and lin28b

(2009) Rebecca Cotterman et al.   PLoS One

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

(2009) J. J. Molenaar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumours

(2008) Helena Carén et al.   BIOCHEMICAL JOURNAL

Lack of correlation between MYCN expression and the Warburg effect in neuroblastoma cell lines

(2008) Danielle J Smith et al.   BMC CANCER

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

(2008) Jianxia Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma

(2008) M. D. Hogarty et al.   CANCER RESEARCH

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

(2008) Elisa Laurenti et al.   Cell Stem Cell

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Identification of ALK as a major familial neuroblastoma predisposition gene

(2008) Yaël P. Mossé et al.   NATURE

Activating mutations in ALK provide a therapeutic target in neuroblastoma

(2008) Rani E. George et al.   NATURE

Oncogenic mutations of ALK kinase in neuroblastoma

(2008) Yuyan Chen et al.   NATURE

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

(2008) Isabelle Janoueix-Lerosey et al.   NATURE

High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma

(2008) E. Fredlund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA