A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer

(2015) M. E. Diefenbacher et al.   CANCER RESEARCH

Aurora kinase A in gastrointestinal cancers: time to target

(2015) Ahmed Katsha et al.   Molecular Cancer

Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer

(2015) Juan Miguel Mosquera et al.   NEOPLASIA

Drugging MYCN through an Allosteric Transition in Aurora Kinase A

(2014) William Clay Gustafson et al.   CANCER CELL

Hepatocellular carcinoma: clinical frontiers and perspectives

(2014) Jordi Bruix et al.   GUT

Investigational Aurora A kinase inhibitor alisertib (MLN8237) as an enteric-coated tablet formulation in non-hematologic malignancies: Phase 1 dose-escalation study

(2014) Gerald Falchook et al.   INVESTIGATIONAL NEW DRUGS

Aurora kinase A mediates c-Myc's oncogenic effects in hepatocellular carcinoma

(2014) Longfeng Lu et al.   MOLECULAR CARCINOGENESIS

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

(2014) Ramona Rudalska et al.   NATURE MEDICINE

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

(2013) Markus Brockmann et al.   CANCER CELL

A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration

(2013) Torsten Wuestefeld et al.   CELL

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

Association Between Nonalcoholic Fatty Liver Disease and Risk for Hepatocellular Cancer, Based on Systematic Review

(2012) Donna L. White et al.   Clinical Gastroenterology and Hepatology

Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: Evidence from a systematic review and meta-analysis

(2012) Jiangbo Liu et al.   EUROPEAN JOURNAL OF CANCER

New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectives

(2012) Christoph Welsch et al.   GUT

Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model

(2011) Hongfeng Yuan et al.   CARCINOGENESIS

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Emerging strategies in the treatment of advanced hepatocellular carcinoma: the role of targeted therapies

(2011) R. Lord et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

(2011) H. Beltran et al.   Cancer Discovery

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

(2009) Tobias Otto et al.   CANCER CELL

A Class of 2,4-Bisanilinopyrimidine Aurora A Inhibitors with Unusually High Selectivity against Aurora B†

(2009) Ignacio Aliagas-Martin et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

(2008) Lars Zender et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Aurora A Is Essential for Early Embryonic Development and Tumor Suppression

(2008) Lin-Yu Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Regulation of Serine/Threonine Kinase-15 (STK15) Expression by Hypoxia and HIF-1

(2008) Alexandra Klein et al.   MOLECULAR BIOLOGY OF THE CELL

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced byMycand mutantKras

(2008) Katrina Podsypanina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase levels determine chemotherapy responsein vitroandin vivo

(2008) Darren J. Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA