Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis

Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma

(2015) A M Puzio-Kuter et al.   CELL DEATH AND DIFFERENTIATION

Histone H3.3 maintains genome integrity during mammalian development

(2015) Chuan-Wei Jang et al.   GENES & DEVELOPMENT

Detained introns are a novel, widespread class of post-transcriptionally spliced introns

(2015) Paul L. Boutz et al.   GENES & DEVELOPMENT

A nano-enabled cancer-specific ITCH RNAi chemotherapy booster for pancreatic cancer

(2015) Maria de la Fuente et al.   Nanomedicine-Nanotechnology Biology and Medicine

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

(2015) E. M. Alexandrova et al.   NATURE

Cell death during crisis is mediated by mitotic telomere deprotection

(2015) Makoto T. Hayashi et al.   NATURE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling

(2015) Elisa Maria Memmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p63 supports aerobic respiration through hexokinase II

(2015) Guiditta Viticchiè et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells

(2015) Jessica M. Hearn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Streptococcus pneumoniaesecretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells

(2015) Prashant Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription factor p63 controls the reserve status but not the stemness of horizontal basal cells in the olfactory epithelium

(2015) Nikolai Schnittke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

(2015) Marianne S. Poruchynsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53

(2015) A Desantis et al.   Cell Death & Disease

Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant

(2015) T L Slatter et al.   Cell Death & Disease

Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells

(2015) Lucilla Bongiorno-Borbone et al.   Oncotarget

Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response

(2014) B C Nair et al.   CELL DEATH AND DIFFERENTIATION

p53-directed translational control can shape and expand the universe of p53 target genes

(2014) S Zaccara et al.   CELL DEATH AND DIFFERENTIATION

KMTase Set7/9 is a critical regulator of E2F1 activity upon genotoxic stress

(2014) L Lezina et al.   CELL DEATH AND DIFFERENTIATION

Suppression of acetylpolyamine oxidase by selected AP-1 members regulates DNp73 abundance: mechanistic insights for overcoming DNp73-mediated resistance to chemotherapeutic drugs

(2014) W Bunjobpol et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation

(2014) S Peuget et al.   CELL DEATH AND DIFFERENTIATION

MicroRNAs and p63 in epithelial stemness

(2014) E Candi et al.   CELL DEATH AND DIFFERENTIATION

Expanding the reach of the p53 tumor suppressor network

(2014) G P Zambetti   CELL DEATH AND DIFFERENTIATION

Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ

(2014) H Solomon et al.   CELL DEATH AND DIFFERENTIATION

Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response

(2014) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

p63 and p73 coordinate p53 function to determine the balance between survival, cell death and senescence in adult neural precursor cells

(2014) M P Fatt et al.   CELL DEATH AND DIFFERENTIATION

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo

(2014) T J Phesse et al.   CELL DEATH AND DIFFERENTIATION

p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis

(2014) A R Yallowitz et al.   CELL DEATH AND DIFFERENTIATION

TAK1 control of cell death

(2014) S R Mihaly et al.   CELL DEATH AND DIFFERENTIATION

AMPK couples p73 with p53 in cell fate decision

(2014) Y Adamovich et al.   CELL DEATH AND DIFFERENTIATION

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

Lats2 is critical for the pluripotency and proper differentiation of stem cells

(2014) Y Aylon et al.   CELL DEATH AND DIFFERENTIATION

Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage

(2014) H-H Zhang et al.   CELL DEATH AND DIFFERENTIATION

Antitumor effect of miR-197 targeting in p53 wild-type lung cancer

(2014) M E Fiori et al.   CELL DEATH AND DIFFERENTIATION

A unique role for p53 in the regulation of M2 macrophage polarization

(2014) L Li et al.   CELL DEATH AND DIFFERENTIATION

Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations

(2014) Ahsan S. Farooqi et al.   JOURNAL OF NEURO-ONCOLOGY

WWP2-WWP1 Ubiquitin Ligase Complex Coordinated by PPM1G Maintains the Balance between Cellular p73 and  Np73 Levels

(2014) N. Chaudhary et al.   MOLECULAR AND CELLULAR BIOLOGY

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo

(2014) Avinashnarayan Venkatanarayan et al.   NATURE

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

UbcH7 regulates 53BP1 stability and DSB repair

(2014) Xiangzi Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity

(2014) Marina Stantic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation

(2014) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells

(2014) S Sane et al.   Cell Death & Disease

ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells

(2014) Y Ci et al.   Cell Death & Disease

Revisiting caspases in sepsis

(2014) M Aziz et al.   Cell Death & Disease

OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation

(2014) W L Ng et al.   Cell Death & Disease

A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

(2014) J Cheng et al.   Cell Death & Disease

ΔNp63α activates CD82 metastasis suppressor to inhibit cancer cell invasion

(2014) J Wu et al.   Cell Death & Disease

JNK–NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress

(2014) A Kostecka et al.   Cell Death & Disease

Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction

(2014) O Fortunato et al.   Cell Death & Disease

ATG5 can regulate p53 expression and activation

(2014) H U Simon et al.   Cell Death & Disease

The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression

(2014) M S Becker et al.   Cell Death & Disease

RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38

(2014) A Weilbacher et al.   Cell Death & Disease

p53 induces skin aging by depleting Blimp1+ sebaceous gland cells

(2014) J Kim et al.   Cell Death & Disease

Mir-509-5p joins the Mdm2/p53 feedback loop and regulates cancer cell growth

(2014) Z-J Ren et al.   Cell Death & Disease

Degradation of mutant p53H175 protein by Zn(II) through autophagy

(2014) A Garufi et al.   Cell Death & Disease

Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity

(2014) J Xu et al.   Cell Death & Disease

High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy

(2014) M Rossi et al.   Cell Death & Disease

A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4

(2014) A G Evstafieva et al.   Cell Death & Disease

Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1)

(2014) J Huang et al.   Cell Death & Disease

Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage

(2014) N Dashzeveg et al.   Cell Death & Disease

 Np63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis

(2013) H. K. Bid et al.   CANCER RESEARCH

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium

(2013) R Wang et al.   CELL DEATH AND DIFFERENTIATION

p53 talks to PARP: the increasing complexity of p53-induced cell death

(2013) K G Wiman   CELL DEATH AND DIFFERENTIATION

miR-661 downregulates both Mdm2 and Mdm4 to activate p53

(2013) Y Hoffman et al.   CELL DEATH AND DIFFERENTIATION

p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene

(2013) Z He et al.   CELL DEATH AND DIFFERENTIATION

Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments

(2013) H Inoue et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

CLP1 links tRNA metabolism to progressive motor-neuron loss

(2013) Toshikatsu Hanada et al.   NATURE

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo

(2013) F. Billia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-24 affects hair follicle morphogenesis targeting Tcf-3

(2013) I Amelio et al.   Cell Death & Disease

Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy

(2013) Z Salah et al.   Cell Death & Disease

Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging

(2013) P Burnley et al.   Cell Death & Disease

miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress

(2013) L Lezina et al.   Cell Death & Disease

Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome

(2013) C Manzl et al.   Cell Death & Disease

Neuroblastoma and MYCN

(2013) M. Huang et al.   Cold Spring Harbor Perspectives in Medicine

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The flick of a switch: which death program to choose?

(2012) P Vandenabeele et al.   CELL DEATH AND DIFFERENTIATION

TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses

(2012) R Tomasini et al.   CELL DEATH AND DIFFERENTIATION

MIRUMIR: an online tool to test microRNAs as biomarkers to predict survival in cancer using multiple clinical data sets

(2012) A V Antonov et al.   CELL DEATH AND DIFFERENTIATION

Age-dependent accumulation of genomic aberrations and deregulation of cell cycle and telomerase genes in metastatic neuroblastoma

(2012) Simona Coco et al.   INTERNATIONAL JOURNAL OF CANCER

Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma

(2012) Nai-Kong V. Cheung   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma

(2011) Jing He et al.   CELL CYCLE

SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing

(2011) Y. Chen et al.   GENES & DEVELOPMENT

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

CKIα ablation highlights a critical role for p53 in invasiveness control

(2011) Ela Elyada et al.   NATURE

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

The RAG2 C terminus suppresses genomic instability and lymphomagenesis

(2011) Ludovic Deriano et al.   NATURE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells

(2011) L Gu et al.   ONCOGENE

Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements

(2011) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging importance of ALK in neuroblastoma

(2011) Anna M. Azarova et al.   SEMINARS IN CANCER BIOLOGY

Isoform-specific p73 knockout mice reveal a novel role for  Np73 in the DNA damage response pathway

(2010) M. T. Wilhelm et al.   GENES & DEVELOPMENT

Heterochromatin silencing of p53 target genes by a small viral protein

(2010) Conrado Soria et al.   NATURE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential control of TAp73 and  Np73 protein stability by the ring finger ubiquitin ligase PIR2

(2010) B. S. Sayan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

New therapeutic targets for the treatment of high-risk neuroblastoma

(2009) Lars M. Wagner et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Small but effective moves towards a greener China

(2009) Wanxin Li   NATURE

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73

(2009) A Peschiaroli et al.   ONCOGENE

HIF2  inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

(2009) J. A. Bertout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of p53 multimerization by Ubc13 is JNK-regulated

(2009) I. Topisirovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

(2008) G Melino et al.   CELL DEATH AND DIFFERENTIATION

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

(2008) R. Tomasini et al.   GENES & DEVELOPMENT

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

A skin microRNA promotes differentiation by repressing ‘stemness’

(2008) Rui Yi et al.   NATURE

Identification of ALK as a major familial neuroblastoma predisposition gene

(2008) Yaël P. Mossé et al.   NATURE

Activating mutations in ALK provide a therapeutic target in neuroblastoma

(2008) Rani E. George et al.   NATURE

Oncogenic mutations of ALK kinase in neuroblastoma

(2008) Yuyan Chen et al.   NATURE

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

(2008) Isabelle Janoueix-Lerosey et al.   NATURE

p73α isoforms drive opposite transcriptional and post-transcriptional regulation of MYCN expression in neuroblastoma cells

(2008) Emilie Horvilleur et al.   NUCLEIC ACIDS RESEARCH