RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
Published 2011 View Full Article
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Title
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 108, Issue 8, Pages 3336-3341
Publisher
Proceedings of the National Academy of Sciences
Online
2011-02-03
DOI
10.1073/pnas.1012351108
References
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Related references
Note: Only part of the references are listed.- High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma
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- New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network
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- The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106
- (2010) M. I. Walton et al. MOLECULAR CANCER THERAPEUTICS
- Recent Advances in Neuroblastoma
- (2010) John M. Maris NEW ENGLAND JOURNAL OF MEDICINE
- Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma
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- Constitutive Activation of the DNA Damage Signaling Pathway in Acute Myeloid Leukemia with Complex Karyotype: Potential Importance for Checkpoint Targeting Therapy
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- PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts
- (2009) C. Zhang et al. CLINICAL CANCER RESEARCH
- Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer
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- (2009) Clark C Chen et al. Molecular Cancer
- Common variations in BARD1 influence susceptibility to high-risk neuroblastoma
- (2009) Mario Capasso et al. NATURE GENETICS
- Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
- (2009) J. J. Molenaar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
- (2008) N Bucher et al. BRITISH JOURNAL OF CANCER
- Cyclin D1 and CDK4 Activity Contribute to the Undifferentiated Phenotype in Neuroblastoma
- (2008) J. J. Molenaar et al. CANCER RESEARCH
- Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3
- (2008) Samuel Sidi et al. CELL
- ATR signaling can drive cells into senescence in the absence of DNA breaks
- (2008) L. I. Toledo et al. GENES & DEVELOPMENT
- A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor Gene
- (2008) K. A. Cole et al. MOLECULAR CANCER RESEARCH
- AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
- (2008) S. D. Zabludoff et al. MOLECULAR CANCER THERAPEUTICS
- Identification of ALK as a major familial neuroblastoma predisposition gene
- (2008) Yaël P. Mossé et al. NATURE
- Activating mutations in ALK provide a therapeutic target in neuroblastoma
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- Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control
- (2008) D. Wilsker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma
- (2008) E. Fredlund et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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