Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

(2017) Kelley S. Yan et al.   NATURE

CD34+mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury

(2017) Igor Stzepourginski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

(2017) Zhen Qi et al.   Nature Communications

Engineered Microenvironments to Direct Epidermal Stem Cell Behavior at Single-Cell Resolution

(2016) Fiona M. Watt   DEVELOPMENTAL CELL

Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease

(2016) Manolis Roulis et al.   DIFFERENTIATION

Epigenetics in Intestinal Epithelial Cell Renewal

(2016) Alireza Roostaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms

(2015) Laura Novellasdemunt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pericytes at the intersection between tissue regeneration and pathology: Figure 1

(2015) Alexander Birbrair et al.   CLINICAL SCIENCE

Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

(2015) Panagiotis S. Kabouridis et al.   NEURON

Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

(2015) Andrew M Handorf et al.   Organogenesis

Inflammation, Innate Immunity, and the Intestinal Stromal Cell Niche: Opportunities and Challenges

(2015) Benjamin M. J. Owens   Frontiers in Immunology

Compensatory Flux Changes within an Endocytic Trafficking Network Maintain Thermal Robustness of Notch Signaling

(2014) Hideyuki Shimizu et al.   CELL

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Lineage selection and plasticity in the intestinal crypt

(2014) Anna Philpott et al.   CURRENT OPINION IN CELL BIOLOGY

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

(2014) Z. Kabiri et al.   DEVELOPMENT

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

Dual role of YAP and TAZ in renewal of the intestinal epithelium

(2014) Masamichi Imajo et al.   NATURE CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enteric glial cells and their role in the intestinal epithelial barrier

(2014) Yan-Bo Yu   WORLD JOURNAL OF GASTROENTEROLOGY

The Role of Matrix Metalloproteinases in Colorectal Cancer

(2014) Anan Said et al.   Cancers

Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling

(2013) Shuji Yamamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Intestinal Regeneration: YAP—Tumor Suppressor and Oncoprotein?

(2013) Vivian S.W. Li et al.   CURRENT BIOLOGY

Integrin signaling is required for maintenance and proliferation of intestinal stem cells in Drosophila

(2013) Guonan Lin et al.   DEVELOPMENTAL BIOLOGY

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors

(2013) Florence Schaffner et al.   Cancers

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells

(2012) Henner F. Farin et al.   GASTROENTEROLOGY

Intestinal stromal cells in mucosal immunity and homeostasis

(2012) B M J Owens et al.   Mucosal Immunology

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)

(2012) A. Durand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF

(2011) Laurianne Van Landeghem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intestinal myofibroblasts: targets for stem cell therapy

(2011) R. C. Mifflin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis

(2011) Carol A. de la Motte   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism

(2011) Terrence E. Riehl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mesenchymal Cells of the Intestinal Lamina Propria

(2011) D.W. Powell et al.   Annual Review of Physiology

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

(2011) K. L. VanDussen et al.   DEVELOPMENT

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

(2011) François Gerbe et al.   JOURNAL OF CELL BIOLOGY

Collagen VI is a basement membrane component that regulates epithelial cell–fibronectin interactions

(2011) Jean-François Groulx et al.   MATRIX BIOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

Notch Lineages and Activity in Intestinal Stem Cells Determined by a New Set of Knock-In Mice

(2011) Silvia Fre et al.   PLoS One

Integrin α8β1 confers anoikis susceptibility to human intestinal epithelial crypt cells

(2010) Yannick D. Benoit et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ephrins and Eph receptors in stem cells and cancer

(2010) Maria Genander et al.   CURRENT OPINION IN CELL BIOLOGY

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

Loss of Indian Hedgehog Activates Multiple Aspects of a Wound Healing Response in the Mouse Intestine

(2010) Willemijn A. van Dop et al.   GASTROENTEROLOGY

Indian Hedgehog Regulates Intestinal Stem Cell Fate Through Epithelial−Mesenchymal Interactions During Development

(2010) Cynthia Kosinski et al.   GASTROENTEROLOGY

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors

(2010) Johan H. van Es et al.   Nature Communications

Integrin α8β1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism

(2009) Yannick D. Benoit et al.   BIOLOGY OF THE CELL

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

A study on the interactions between heparan sulfate proteoglycans and Wnt proteins

(2009) Christophe Fuerer et al.   DEVELOPMENTAL DYNAMICS

Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism

(2009) David Gagné et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Requirement of Notch activation during regeneration of the intestinal epithelia

(2008) Ryuichi Okamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

β1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms

(2008) Véronique Bouchard et al.   APOPTOSIS

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

(2008) Orbicia Riccio et al.   EMBO REPORTS

Laminin  5 influences the architecture of the mouse small intestine mucosa

(2008) Z. X. Mahoney et al.   JOURNAL OF CELL SCIENCE