Epigenetics in Intestinal Epithelial Cell Renewal

HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

(2015) R. Carson et al.   CLINICAL CANCER RESEARCH

HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis

(2015) Cheryl D. Zimberlin et al.   FASEB JOURNAL

Loss of histone deacetylase Hdac1 disrupts metabolic processes in intestinal epithelial cells

(2015) Alexis Gonneaud et al.   FEBS LETTERS

Histone Deacetylase Inhibition Impairs Normal Intestinal Cell Proliferation and Promotes Specific Gene Expression

(2015) Alireza Roostaee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

G9a co-suppresses LINE1 elements in spermatogonia

(2014) Monica Di Giacomo et al.   Epigenetics & Chromatin

The central role of EED in the orchestration of polycomb group complexes

(2014) Qi Cao et al.   Nature Communications

Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts

(2014) Ganesh N. Pandian et al.   Scientific Reports

Src family kinase inhibitor PP2 accelerates differentiation in human intestinal epithelial cells

(2013) Amira Seltana et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic regulation of colon cancer and intestinal stem cells

(2013) Saher Sue Hammoud et al.   CURRENT OPINION IN CELL BIOLOGY

Redistribution of H3K27me3 and acetylated histone H4 upon exposure to azacitidine and decitabine results in de-repression of the AML1/ETO target geneIL3

(2013) Francesca Buchi et al.   Epigenetics

Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells

(2013) Yannick D. Benoit et al.   EXPERIMENTAL CELL RESEARCH

Recruitment and Biological Consequences of Histone Modification of H3K27me3 and H3K9me3

(2013) J. Kim et al.   ILAR JOURNAL

HDAC1 and HDAC2 Restrain the Intestinal Inflammatory Response by Regulating Intestinal Epithelial Cell Differentiation

(2013) Naomie Turgeon et al.   PLoS One

Epigenetic Reprogramming in Cancer

(2013) M. L. Suva et al.   SCIENCE

Polycomb repressive complex 2 impedes intestinal cell terminal differentiation

(2012) Y. D. Benoit et al.   JOURNAL OF CELL SCIENCE

Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells

(2012) Yannick D. Benoit et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epigenetic alterations involved in cancer stem cell reprogramming

(2012) Purificación Muñoz et al.   Molecular Oncology

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Effects of heterochromatin in colorectal cancer stem cells on radiosensitivity

(2012) Ting Chen et al.   Chinese Journal of Cancer

Linking DNA replication to heterochromatin silencing and epigenetic inheritance

(2011) Qing Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Notch: Architect, Landscaper, and Guardian of the Intestine

(2011) Marc Vooijs et al.   GASTROENTEROLOGY

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Enhancer function: new insights into the regulation of tissue-specific gene expression

(2011) Chin-Tong Ong et al.   NATURE REVIEWS GENETICS

Cooperation between HNF-1α, Cdx2, and GATA-4 in initiating an enterocytic differentiation program in a normal human intestinal epithelial progenitor cell line

(2010) Yannick D. Benoit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer

(2010) Martin Sauvageau et al.   Cell Stem Cell

HDACs and HDAC inhibitors in colon cancer

(2010) John M. Mariadason   Epigenetics

Epigenetic factors in cancer development: Polycomb group proteins

(2010) Andrea Piunti et al.   Future Oncology

Deregulation of H3K27 methylation in cancer

(2010) Eva Martinez-Garcia et al.   NATURE GENETICS

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

Intestinal stem cells and epithelial–mesenchymal interactions in the crypt and stem cell niche

(2010) Anisa Shaker et al.   Translational Research

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

(2009) W. Fiskus et al.   BLOOD

Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells

(2009) Elena Ezhkova et al.   CELL

The stem cells of small intestinal crypts: where are they?

(2009) C. S. Potten et al.   CELL PROLIFERATION

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Histone H3 modifications and Cdx-2 binding to the sucrase–isomaltase (SI) gene is involved in induction of the gene in the transition from the crypt to villus in the small intestine of rats

(2008) Takuji Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

Current View: Intestinal Stem Cells and Signaling

(2008) David H. Scoville et al.   GASTROENTEROLOGY

The intestinal stem cell

(2008) N. Barker et al.   GENES & DEVELOPMENT

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

(2008) Andrew J. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH