Article
Oncology
Fu-Long Li, Kun-Liang Guan
Summary: The Hippo signaling pathway is an important regulatory pathway that plays a vital role in animal development and tissue homeostasis. It regulates tissue growth and organ size and is associated with various diseases, particularly cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell Biology
Jing Cai, Kyungsuk Choi, Hongde Li, Katiuska Daniela Pulgar Prieto, Yonggang Zheng, Duojia Pan
Summary: This study reveals that the essential role of YAP in liver and lung development can be bypassed by inactivation of the TEAD corepressor VGLL4, indicating that YAP's major physiological function is to antagonize VGLL4. The findings highlight the central importance of VGLL4-mediated transcriptional repression in regulating the Hippo pathway and provide insights into potential strategies for modulating Hippo signaling in cancer and regenerative medicine.
GENES & DEVELOPMENT
(2022)
Article
Biochemistry & Molecular Biology
Oriane Guillermin, Nikolaos Angelis, Clara M. Sidor, Rachel Ridgway, Anna Baulies, Anna Kucharska, Pedro Antas, Melissa R. Rose, Julia Cordero, Owen Sansom, Vivian S. W. Li, Barry J. Thompson
Summary: Wnt signaling induces gradient proliferation of stem/progenitor cells along the intestinal axis, with YAP-TEAD acting as a key downstream effector. YAP regulates the sensitivity of crypt stem cells to apoptosis and cell proliferation during regeneration, and its nuclear localization is influenced by Src family kinase. The interaction between Wnt and Src-YAP signals plays a crucial role in driving intestinal regeneration.
Article
Biochemistry & Molecular Biology
Yang Li, Min Liu, Shuting Yang, Ashley M. Fuller, T. S. Karin Eisinger-Mathason, Shuying Yang
Summary: This study identifies RGS12 as a novel tumor suppressor in osteosarcoma through inhibiting the YAP-TEAD1-Ezrin signaling pathway and provides evidence that targeting RGS12 may be a therapeutic strategy for osteosarcoma.
Article
Biochemistry & Molecular Biology
Fansen Meng, Zhengyang Yu, Dan Zhang, Shasha Chen, Hongxin Guan, Ruyuan Zhou, Qirou Wu, Qian Zhang, Shengduo Liu, Mukesh Kumar Venkat Ramani, Bing Yang, Xiao-Qun Ba, Jing Zhang, Jun Huang, Xueli Bai, Jun Qin, Xin-Hua Feng, Songying Ouyang, Yan Jessie Zhang, Tingbo Liang, Pinglong Xu
Summary: Mutations in the tumor suppressor NF2 can affect tumor formation by impacting anti-tumor immune mechanisms, revealing a novel pathogenic mechanism for NF2-related tumors.
Article
Biochemistry & Molecular Biology
Ruyuan Zhou, Qirou Wu, Mengqiu Wang, Seema Irani, Xiao Li, Qian Zhang, Fansen Meng, Shengduo Liu, Fei Zhang, Liming Wu, Xia Lin, Xiaojian Wang, Jian Zou, Hai Song, Jun Qin, Tingbo Liang, Xin-Hua Feng, Yan Jessie Zhang, Pinglong Xu
Summary: This study identified PPM1A as the physiological phosphatase of YAP/TAZ, revealing its critical effects in YAP/TAZ cellular distribution and its physiological roles in mammalian organ regeneration.
Article
Cell Biology
Yu Wang, Yuwen Zhu, Yuan Gu, Mingyue Ma, Yebin Wang, Sixian Qi, Yan Zeng, Rui Zhu, Xueying Wang, Pengcheng Yu, Jianhui Xu, Yilai Shu, Fa-Xing Yu
Summary: Mutations in the NF2 gene result in neurofibromatosis type 2, impacting the Hippo signaling pathway and leading to increased YAP/TAZ activity, promoting tumorigenesis.
Article
Multidisciplinary Sciences
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Summary: This study identified KIRREL1 as an upstream positive regulator of the mammalian Hippo pathway, which controls cell proliferation by sensing cell-cell contact and recruiting SAV1 to cell-cell contact sites.
NATURE COMMUNICATIONS
(2022)
Review
Genetics & Heredity
Huizhen Wang, Yida Lu, Mingliang Wang, Youliang Wu, Xiaodong Wang, Yongxiang Li
Summary: Although gastric cancer pathogenesis is not completely understood, it involves the activation of oncogenes and inactivation of tumor suppressor genes. E3 ubiquitin ligases play dual roles in gastric carcinogenesis, acting as both oncoproteins and tumor suppressors, and regulate cell growth, apoptosis, and the cell cycle, leading to cisplatin resistance that limits treatment efficacy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Multidisciplinary Sciences
Laura M. Pikkupeura, Raul B. Bressan, Jordi Guiu, Yun Chen, Martti Maimets, Daniela Mayer, Pawel J. Schweiger, Stine L. Hansen, Grzegorz J. Maciag, Hjalte L. Larsen, Kadi Lohmussaar, Marianne Terndrup Pedersen, Joji M. Yap Teves, Jette Bornholdt, Vladimir Benes, Albin Sandelin, Kim B. Jensen
Summary: During intestinal organogenesis, the maturation of intestinal stem cells is not fully understood. In this study, we used intestinal organoid cultures to analyze the transcriptional, chromatin accessibility, DNA methylation, and three-dimensional chromatin conformation landscapes in fetal and adult epithelial cells. We found differences in gene expression, enhancer activity, 3D organization, DNA accessibility, and methylation between the two states. We identified sustained Yes-Associated Protein (YAP) activity as a major regulator of the immature fetal state, likely coordinated by changes in extracellular matrix composition.
Review
Genetics & Heredity
Kailang Li, Jinyun Li, Meng Ye, Xiaofeng Jin
Summary: Siah2 plays a crucial role in human cancer by promoting tumorigenesis or acting as a tumor suppressor through proteasome-mediated degradation of oncoproteins. It is subject to complex regulation, including phosphorylation by various protein kinases to control stability and activity.
Review
Oncology
Juan Luo, Liang Deng, Hailin Zou, Yibo Guo, Tongyu Tong, Mingli Huang, Gengqiang Ling, Peng Li
Summary: Hippo signaling pathway plays a crucial role in organ size control by regulating cell proliferation and anti-apoptosis. Dysregulation of this pathway is implicated in cancer development and progression. YAP/TAZ are the downstream effectors of Hippo pathway, and their overexpression or activation can promote tumor initiation and progression, as well as recurrence and therapeutic resistance. However, YAP/TAZ also have tumor-suppressive functions in certain contexts, caution should be taken when targeting Hippo signaling in clinical trials.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Nan Wang, Yetong Dong, Xiejun Xu, Yingjie Shen, Zhiyuan Huang, Yin Yu, Zhili Liu, Wenjie Gong, Siyi Zhang, Yeyi Zheng, Yonghuan Song, Zhongxin Zhu, Litai Jin, Weitao Cong
Summary: The study found that FGF10 promotes keratinocyte proliferation and plays a protective role against UVB-induced skin damage. Additionally, FGF10 alleviates the downregulation of YAP activity induced by UVB, promoting keratinocyte proliferation.
CELL PROLIFERATION
(2022)
Article
Biochemistry & Molecular Biology
Mengfei Wang, Qin Yan, Yunfeng Song, Zhenbo Zhang, Xiaojun Chen, Kun Gao, Xiaoping Wan
Summary: This study reveals that the transcription factor SOX17 acts as a tumor suppressor in endometrial cancer by inhibiting the transcriptional outputs of the Hippo-YAP/TEAD pathway. SOX17 binds to TEAD and attenuates its DNA-binding ability. Small molecule inhibitors of YAP/TEAD or the FDA-approved drug cabozantinib can reverse the malignant transformation caused by SOX17 mutations.
Review
Gastroenterology & Hepatology
Jacquelyn O. Russell, Fernando D. Camargo
Summary: The Hippo signalling pathway plays a crucial role in liver biology, including development, cell fate determination, homeostatic function, and regeneration. Pathological activation of the downstream YAP-TAZ signalling has been implicated in chronic liver diseases, making the development of inhibitors for this pathway important.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Immunology
T. Schwerd, R. V. Bryant, S. Pandey, M. Capitani, L. Meran, J-B Cazier, J. Jung, K. Mondal, M. Parkes, C. G. Mathew, K. Fiedler, D. J. McCarthy, P. B. Sullivan, A. Rodrigues, S. P. L. Travis, C. Moore, J. Sambrook, W. H. Ouwehand, D. J. Roberts, J. Danesh, R. K. Russell, D. C. Wilson, J. R. Kelsen, R. Cornall, L. A. Denson, S. Kugathasan, U. G. Knaus, E. G. Serra, C. A. Anderson, R. H. Duerr, D. P. B. Mcgovern, J. Cho, F. Powrie, V. S. W. Li, A. M. Muise, H. H. Uhlig
MUCOSAL IMMUNOLOGY
(2018)
Article
Cell Biology
Laura Novellasdemunt, Valentina Foglizzo, Laura Cuadrado, Pedro Antas, Anna Kucharska, Vesela Encheva, Ambrosius P. Snijders, Vivian S. W. Li
Correction
Biochemistry & Molecular Biology
Tokameh Mahmoudi, Sylvia F. Boj, Pantelis Hatzis, Vivian S. W. Li, Nadia Taouatas, Robert G. J. Vries, Hans Teunissen, Harry Begthel, Jeroen Korving, Shabaz Mohammed, Albert J. R. Heck, Hans Clevers
Review
Cell & Tissue Engineering
Laween Meran, Anna Baulies, Vivian S. W. Li
STEM CELLS INTERNATIONAL
(2017)
Article
Cell Biology
Mario Aguilar-Aragon, Ahmed Elbediwy, Valentina Foglizzo, Georgina C. Fletcher, Vivian S. W. Li, Barry J. Thompson
Article
Immunology
Amina Metidji, Sara Omenetti, Stefania Crotta, Ying Li, Emma Nye, Ellie Ross, Vivian Li, Muralidhara R. Maradana, Chris Schiering, Brigitta Stockinger
Article
Multidisciplinary Sciences
Kai Kretzschmar, Yorick Post, Marie Bannier-Helaouet, Andrea Mattiotti, Jarno Drost, Onur Basak, Vivian S. W. Li, Maaike van den Born, Quinn D. Gunst, Danielle Versteeg, Lieneke Kooijman, Stefan van der Elst, Johan H. van Es, Eva van Rooij, Maurice J. B. van den Hoff, Hans Clevers
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Cell Biology
Pedro Antas, Laura Novellasdemunt, Anna Kucharska, Isobel Massie, Joana Carvalho, Dahmane Oukrif, Emma Nye, Marco Novelli, Vivian S. W. Li
Editorial Material
Cell Biology
Vivian S. W. Li
NATURE CELL BIOLOGY
(2019)
Editorial Material
Cell & Tissue Engineering
Hans Clevers, Ryan K. Conder, Vivian S. W. Li, Matthias P. Lutolf, Ludovic Vallier, Sarah Chan, Tracy C. Grikscheit, Kim B. Jensen, Paolo De Coppi
Article
Biochemistry & Molecular Biology
Laura Novellasdemunt, Anna Kucharska, Cara Jamieson, Maria Prange-Barczynska, Anna Baulies, Pedro Antas, Jelte van der Vaart, Helmuth Gehart, Madelon M. Maurice, Vivian S. W. Li
Article
Biochemical Research Methods
Xiao Qin, Jahangir Sufi, Petra Vlckova, Pelagia Kyriakidou, Sophie E. Acton, Vivian S. W. Li, Mark Nitz, Christopher J. Tape
Article
Multidisciplinary Sciences
Giovanni Giuseppe Giobbe, Claire Crowley, Camilla Luni, Sara Campinoti, Moustafa Khedr, Kai Kretzschmar, Martina Maria De Santis, Elisa Zambaiti, Federica Michielin, Laween Meran, Qianjiang Hu, Gijs van Son, Luca Urbani, Anna Manfredi, Monica Giomo, Simon Eaton, Davide Cacchiarelli, Vivian S. W. Li, Hans Clevers, Paola Bonfanti, Nicola Elvassore, Paolo De Coppi
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Claudia Corro, Laura Novellasdemunt, Vivian S. W. Li
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Gastroenterology & Hepatology
Anna Baulies, Nikolaos Angelis, Valentina Foglizzo, E. Thomas Danielsen, Harshil Patel, Laura Novellasdemunt, Anna Kucharska, Joana Carvalho, Emma Nye, Paolo De Coppi, Vivian S. W. Li
