Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors

α5β1 Integrin Ligand PHSRN Induces Invasion and α5 mRNA in Endothelial Cells to Stimulate Angiogenesis

(2014) Zhao-Zhu Zeng et al.   Translational Oncology

Phase Ib safety and pharmacokinetic study of volociximab, an anti-α5β1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer

(2012) B. Besse et al.   ANNALS OF ONCOLOGY

Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 2

(2012) Bénédicte Delouvrié et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 1

(2012) Bénédicte Delouvrié et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Integrin  5 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

(2012) H. Janouskova et al.   CANCER RESEARCH

ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial–mesenchymal transition of human cancer cells

(2012) Eun-Hee Nam et al.   CARCINOGENESIS

An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia

(2012) Longxuan Li et al.   EXPERIMENTAL NEUROLOGY

A novel treatment for glioblastoma: integrin inhibition

(2012) Marc C Chamberlain et al.   Expert Review of Neurotherapeutics

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

Finding the weakest link – exploring integrin-mediated mechanical molecular pathways

(2012) Pere Roca-Cusachs et al.   JOURNAL OF CELL SCIENCE

Negative regulators of integrin activity

(2012) J. Pouwels et al.   JOURNAL OF CELL SCIENCE

Integrin trafficking at a glance

(2012) R. E. Bridgewater et al.   JOURNAL OF CELL SCIENCE

Integrin bi-directional signaling across the plasma membrane

(2012) Ping Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillin

(2012) Boya Deng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

O(6)-Methylguanine-DNA Methyltransferase Is a Novel Negative Effector of Invasion in Glioblastoma Multiforme

(2012) M. Chahal et al.   MOLECULAR CANCER THERAPEUTICS

TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function and localization in epithelial cells

(2012) K Mythreye et al.   ONCOGENE

Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma

(2012) D Kesanakurti et al.   ONCOGENE

Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF- B network

(2012) K. M. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Steroid Receptor Coactivator-1 Upregulates Integrin  5 Expression to Promote Breast Cancer Cell Adhesion and Migration

(2011) L. Qin et al.   CANCER RESEARCH

Integrin α5β1 controls invasion of human breast carcinoma cells by direct and indirect modulation of MMP-2 collagenase activity

(2011) Galina Morozevich et al.   CELL CYCLE

Mechanisms of integrin activation and trafficking

(2011) Coert Margadant et al.   CURRENT OPINION IN CELL BIOLOGY

Volociximab in cancer

(2011) Salah Almokadem et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

(2011) Katherine M. Bell-McGuinn et al.   GYNECOLOGIC ONCOLOGY

Involvement of the TGFβ pathway in the regulation of α5β1 integrins by caveolin-1 in human glioblastoma

(2011) Erika C. Cosset et al.   INTERNATIONAL JOURNAL OF CANCER

Integrin  5 1 facilitates cancer cell invasion through enhanced contractile forces

(2011) C. T. Mierke et al.   JOURNAL OF CELL SCIENCE

Alcohol promotes breast cancer cell invasion by regulating the Nm23-ITGA5 pathway

(2011) Amy W Wong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Molecular Characterization of the Tumor-Suppressive Function of Nischarin in Breast Cancer

(2011) Somesh Baranwal et al.   JNCI-Journal of the National Cancer Institute

Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis

(2011) Yanfang Wang et al.   Molecular Cancer

The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk

(2011) E Arpaia et al.   ONCOGENE

Suppression of α5 gene expression is closely related to the tumorigenic properties of uveal melanoma cell lines

(2011) Solange Landreville et al.   Pigment Cell & Melanoma Research

Cancer Cell Invasion Is Enhanced by Applied Mechanical Stimulation

(2011) Shalini Menon et al.   PLoS One

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Integrin Inhibitors as a Therapeutic Agent for Ovarian Cancer

(2011) Kenjiro Sawada et al.   Journal of Oncology

α5β1-Integrin Expression Is Essential for Tumor Progression in Experimental Lung Cancer

(2010) Jesse Roman et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The PHSCN dendrimer as a more potent inhibitor of human breast cancer cell invasion, extravasation, and lung colony formation

(2010) Hongren Yao et al.   BREAST CANCER RESEARCH AND TREATMENT

Bcl-2 and β1-integrin predict survival in a tissue microarray of small cell lung cancer

(2010) M H Lawson et al.   BRITISH JOURNAL OF CANCER

Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression

(2010) Vermont P. Dia et al.   CANCER LETTERS

Survivin Enhances Motility of Melanoma Cells by Supporting Akt Activation and  5 Integrin Upregulation

(2010) J. A. McKenzie et al.   CANCER RESEARCH

Kallikrein-Related Peptidase 7 Promotes Multicellular Aggregation via the α5β1Integrin Pathway and Paclitaxel Chemoresistance in Serous Epithelial Ovarian Carcinoma

(2010) Ying Dong et al.   CANCER RESEARCH

Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse after Coordinate Targeting of Integrin  5 1 and Fibronectin

(2010) J.-M. Nam et al.   CANCER RESEARCH

Dual Functional Monoclonal Antibody PF-04605412 Targets Integrin  5 1 and Elicits Potent Antibody-Dependent Cellular Cytotoxicity

(2010) G. Li et al.   CANCER RESEARCH

Increased potency of the PHSCN dendrimer as an inhibitor of human prostate cancer cell invasion, extravasation, and lung colony formation

(2010) Hongren Yao et al.   CLINICAL & EXPERIMENTAL METASTASIS

Endothelial  5 and  v integrins cooperate in remodeling of the vasculature during development

(2010) A. van der Flier et al.   DEVELOPMENT

Ubiquitination of α5β1 Integrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-Integrin Complexes

(2010) Viola Hélène Lobert et al.   DEVELOPMENTAL CELL

α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells

(2010) Eva Martinkova et al.   INTERNATIONAL JOURNAL OF CANCER

ADAM15 to α5β1 integrin switch in colon carcinoma cells: A late event in cancer progression associated with tumor dedifferentiation and poor prognosis

(2010) Claire Toquet et al.   INTERNATIONAL JOURNAL OF CANCER

Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer

(2010) Anne-Marie C Dingemans et al.   Molecular Cancer

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis

(2010) A K Mitra et al.   ONCOGENE

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Integrin signaling and lung cancer

(2010) Francesca Caccavari et al.   Cell Adhesion & Migration

α5β1 Integrin Blockade Inhibits Lymphangiogenesis in Airway Inflammation

(2009) Tatsuma Okazaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Preclinical Evaluation of the Novel Small-Molecule Integrin α5β1 Inhibitor JSM6427 in Monkey and Rabbit Models of Choroidal Neovascularization

(2009) Grit Zahn   ARCHIVES OF OPHTHALMOLOGY

Discovery of orally available integrin α5β1 antagonists

(2009) Gunther Zischinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SAR of N-phenyl piperidine based oral integrin α5β1 antagonists

(2009) Gunther Zischinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling

(2009) Tong-Lay Lau et al.   EMBO JOURNAL

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

(2009) Donatella Valdembri et al.   PLOS BIOLOGY

Caveolin-1 regulates glioblastoma aggressiveness through the control of α5β1 integrin expression and modulates glioblastoma responsiveness to SJ749, an α5β1 integrin antagonist

(2008) Sophie Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Loss of E-Cadherin Promotes Ovarian Cancer Metastasis via  5-Integrin, which Is a Therapeutic Target

(2008) K. Sawada et al.   CANCER RESEARCH

Rational Design of Highly Active and Selective Ligands for the α5β1 Integrin Receptor

(2008) Dominik Heckmann et al.   CHEMBIOCHEM

Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds  5 1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study

(2008) A. D. Ricart et al.   CLINICAL CANCER RESEARCH

Cell-autonomous requirement for  1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice

(2008) T. R. Carlson et al.   DEVELOPMENT

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

Caveolin-1-dependent  1 integrin endocytosis is a critical regulator of fibronectin turnover

(2008) F. Shi et al.   JOURNAL OF CELL SCIENCE

Stimulation of lung carcinoma cell growth by fibronectin–integrin signalling

(2008) Jeffrey D. Ritzenthaler et al.   Molecular BioSystems