Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass

NF-κB Inhibition Protects against Tumor-Induced Cardiac Atrophy in Vivo

(2011) Ashley Wysong et al.   AMERICAN JOURNAL OF PATHOLOGY

PKB signaling and atrogene expression in skeletal muscle of aged mice

(2011) Megan Gaugler et al.   JOURNAL OF APPLIED PHYSIOLOGY

The epidemiology of sarcopenia in community living older adults: what role does lifestyle play?

(2011) David Scott et al.   Journal of Cachexia Sarcopenia and Muscle

Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting

(2010) Norleena P Gullett et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy

(2010) Marco Sandri   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder—murine Pompe disease

(2010) Nina Raben et al.   Autophagy

Fasting-related autophagic response in slow- and fast-twitch skeletal muscle

(2010) Tomonori Ogata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Frailty and muscle metabolism dysregulation in the elderly

(2010) W. J. Evans et al.   BIOGERONTOLOGY

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Genetic Deletion of Myostatin From the Heart Prevents Skeletal Muscle Atrophy in Heart Failure

(2010) Joerg Heineke et al.   CIRCULATION

Signaling pathways perturbing muscle mass

(2010) David J Glass   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Cancer Cachexia: Traditional Therapies and Novel Molecular Mechanism-Based Approaches to Treatment

(2010) Nagi B. Kumar et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny

(2010) Kenneth Day et al.   DEVELOPMENTAL BIOLOGY

TNF-α impairs regulation of muscle oxidative phenotype: implications for cachexia?

(2010) A. H. V. Remels et al.   FASEB JOURNAL

Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function

(2010) Kate T. Murphy et al.   FASEB JOURNAL

Oxidative Stress, Molecular Inflammation and Sarcopenia

(2010) Si-Jin Meng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

(2010) Mikael Altun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

(2010) Pradyut K. Paul et al.   JOURNAL OF CELL BIOLOGY

Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli

(2010) Maurice Hayot et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

(2010) Paolo Grumati et al.   NATURE MEDICINE

Ghrelin for cachexia

(2010) Takashi Akamizu et al.   Journal of Cachexia Sarcopenia and Muscle

Ethical guidelines for authorship and publishing in theJournal of Cachexia, Sarcopenia and Muscle

(2010) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training

(2010) Karsten Lenk et al.   Journal of Cachexia Sarcopenia and Muscle

An overview of sarcopenia: facts and numbers on prevalence and clinical impact

(2010) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis

(2009) Anna Nogalska et al.   ACTA NEUROPATHOLOGICA

The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans

(2009) K. Sakuma et al.   Acta Physiologica

Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia

(2009) Emilie A Wilkes et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Smad2 and 3 transcription factors control muscle mass in adulthood

(2009) Roberta Sartori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease

(2009) Pamela J. Plant et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

Autophagy in chronic obstructive pulmonary disease: Homeostatic or pathogenic mechanism?

(2009) Stefan W. Ryter et al.   Autophagy

Denervation-induced oxidative stress and autophagy signaling in muscle

(2009) Michael F.N. O’Leary et al.   Autophagy

Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

(2009) Margaret E. Benny Klimek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy

(2009) Emanuele Marzetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Molecular profiles of Quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets

(2009) Ilham Chelh et al.   BMC GENOMICS

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Testosterone Supplementation Reverses Sarcopenia in Aging through Regulation of Myostatin, c-Jun NH2-Terminal Kinase, Notch, and Akt Signaling Pathways

(2009) Ekaterina L. Kovacheva et al.   ENDOCRINOLOGY

Atrophy and hypertrophy signalling in the diaphragm of patients with COPD

(2009) D. Testelmans et al.   EUROPEAN RESPIRATORY JOURNAL

Age-related changes of cell death pathways in rat extraocular muscle

(2009) Colleen A. McMullen et al.   EXPERIMENTAL GERONTOLOGY

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

(2009) Stephanie Eva Wohlgemuth et al.   EXPERIMENTAL GERONTOLOGY

Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats

(2009) Isabelle Rieu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength

(2009) L. A. Schaap et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice

(2009) N. K. LeBrasseur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Skeletal Muscle Hypertrophy Following Resistance Training Is Accompanied by a Fiber Type-Specific Increase in Satellite Cell Content in Elderly Men

(2009) L. B. Verdijk et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction

(2009) Emanuele Marzetti et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of cytokines in cancer cachexia

(2009) Josep M Argilés et al.   Current Opinion in Supportive and Palliative Care

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss

(2008) Philip E. Knapp et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy

(2008) Kathryn R. Wagner et al.   ANNALS OF NEUROLOGY

Proteasome activities in the rectus abdominis muscle of young and older individuals

(2008) Maurizio Bossola et al.   BIOGERONTOLOGY

Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness

(2008) James G. Ryall et al.   BIOGERONTOLOGY

Myostatin as a therapeutic target for musculoskeletal disease

(2008) L. Bradley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Skeletal muscle proteolysis in aging

(2008) Lydie Combaret et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Down-Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle

(2008) Adel Amirouche et al.   ENDOCRINOLOGY

Muscle myostatin signalling is enhanced in experimental cancer cachexia

(2008) P. Costelli et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Apoptosis signalling is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditions

(2008) Josep M. Argilés et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modulation of GH/IGF-1 axis: Potential strategies to counteract sarcopenia in older adults

(2008) Silvia Giovannini et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

(2008) Morgan E. Carlson et al.   NATURE

Fiber Type-Specific Nitric Oxide Protects Oxidative Myofibers against Cachectic Stimuli

(2008) Zengli Yu et al.   PLoS One

Human Sarcopenia Reveals an Increase in SOCS-3 and Myostatin and a Reduced Efficiency of Akt Phosphorylation

(2008) Bertrand Léger et al.   REJUVENATION RESEARCH

Tumor Necrosis Factor-α Inhibition of Skeletal Muscle Regeneration Is Mediated by a Caspase-Dependent Stem Cell Response

(2008) Viviana Moresi et al.   STEM CELLS

Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle

(2007) Emanuele Marzetti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Muscle wasting in diabetic and in tumor-bearing rats: Role of oxidative stress

(2007) Raffaella Mastrocola et al.   FREE RADICAL BIOLOGY AND MEDICINE