Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

Polyphosphoinositide binding domains: Key to inositol lipid biology

(2015) Gerald R.V. Hammond et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PI3K signalling in inflammation

(2015) P.T. Hawkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer

(2015) Carlotta Costa et al.   CANCER CELL

Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ

(2015) Sarit Schwartz et al.   CANCER CELL

Fc receptor inside-out signaling and possible impact on antibody therapy

(2015) Arianne M. Brandsma et al.   IMMUNOLOGICAL REVIEWS

The regulatory subunits of PI3Kγ control distinct neutrophil responses

(2015) Arnaud Deladeriere et al.   Science Signaling

A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis

(2015) Haluk Yuzugullu et al.   Nature Communications

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells

(2015) Julie Guillermet-Guibert et al.   PLoS Genetics

The regulatory subunits of PI3Kγ control distinct neutrophil responses

(2015) Arnaud Deladeriere et al.   Science Signaling

PI3Kβ downstream of GPCRs – crucial partners in oncogenesis

(2015) Hashem A Dbouk et al.   Oncotarget

Platelet PI3K  and GSK3 regulate thrombus stability at a high shear rate

(2014) P.-A. Laurent et al.   BLOOD

P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils

(2014) G. Damoulakis et al.   JOURNAL OF CELL SCIENCE

Characterization of the Novel and Specific PI3K  Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials

(2014) C. Fritsch et al.   MOLECULAR CANCER THERAPEUTICS

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

(2014) Dejan Juric et al.   NATURE

The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice

(2014) Dávid Győri et al.   Arthritis & Rheumatology

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

(2013) Klaus Okkenhaug   Annual Review of Immunology

Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases

(2013) Rachel Schnur Salamon et al.   BIOESSAYS

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

(2013) Pascal Furet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

(2013) Ralph Fritsch et al.   CELL

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

(2013) Lazaros C. Foukas et al.   EMBO Molecular Medicine

Specific inhibition of PI3K p110δ inhibits CSF-1-induced macrophage spreading and invasive capacity

(2013) Kellie A. Mouchemore et al.   FEBS Journal

Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation

(2013) Zhixun Dou et al.   MOLECULAR CELL

Molecular determinants of PI3K -mediated activation downstream of G-protein-coupled receptors (GPCRs)

(2013) O. Vadas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inside-out, outside-in, and inside–outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction

(2012) Bo Shen et al.   CURRENT OPINION IN CELL BIOLOGY

Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor

(2012) S. NYLANDER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110  (PIK3CA)

(2012) J. E. Burke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G Protein-Coupled Receptor-Mediated Activation of p110  by G   Is Required for Cellular Transformation and Invasiveness

(2012) H. A. Dbouk et al.   Science Signaling

Progress in the Preclinical Discovery and Clinical Development of Class I and Dual Class I/IV Phosphoinositide 3-Kinase (PI3K) Inhibitors

(2011) S. J. Shuttleworth et al.   CURRENT MEDICINAL CHEMISTRY

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry

(2011) Jonathan Clark et al.   NATURE METHODS

PI3K  Plays a Critical Role in Neutrophil Activation by Immune Complexes

(2011) S. Kulkarni et al.   Science Signaling

Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions

(2011) Carlotta Costa et al.   TheScientificWorldJOURNAL

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

(2010) K. E. Anderson et al.   BLOOD

Leukotriene B4Augments and Restores FcγRs-dependent Phagocytosis in Macrophages

(2010) Fuyuki Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility

(2010) Elisa Ciraolo et al.   MOLECULAR BIOLOGY OF THE CELL

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fine tuning the immune response with PI3K

(2009) David A. Fruman et al.   IMMUNOLOGICAL REVIEWS

Regulation of phosphoinositide 3-kinase expression in health and disease

(2009) Klaartje Kok et al.   TRENDS IN BIOCHEMICAL SCIENCES

CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks

(2008) K. E. Anderson et al.   BLOOD

Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages

(2008) E. A. Papakonstanti et al.   JOURNAL OF CELL SCIENCE

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

(2008) Shidong Jia et al.   NATURE

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN-deficient cancers depend on PIK3CB

(2008) S. Wee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-Kinase p110  Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

(2008) E. Ciraolo et al.   Science Signaling