Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel

The lipid habitats of neurotransmitter receptors in brain

(2016) María Virginia Borroni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Docosahexaenoic acid: one molecule diverse functions

(2016) Michio Hashimoto et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

The M4 Transmembrane α-Helix Contributes Differently to Both the Maturation and Function of Two Prokaryotic Pentameric Ligand-gated Ion Channels

(2015) Camille M. Hénault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A chimeric prokaryotic pentameric ligand–gated channel reveals distinct pathways of activation

(2015) Nicolaus Schmandt et al.   JOURNAL OF GENERAL PHYSIOLOGY

The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold

(2015) Giovanni Gonzalez-Gutierrez et al.   JOURNAL OF GENERAL PHYSIOLOGY

Glycine receptor mechanism elucidated by electron cryo-microscopy

(2015) Juan Du et al.   NATURE

Conformational Changes Underlying Desensitization of the Pentameric Ligand-Gated Ion Channel ELIC

(2015) Monica N. Kinde et al.   STRUCTURE

Role of the Fourth Transmembrane α Helix in the Allosteric Modulation of Pentameric Ligand-Gated Ion Channels

(2015) Casey L. Carswell et al.   STRUCTURE

The desensitization gate of inhibitory Cys-loop receptors

(2015) Marc Gielen et al.   Nature Communications

Structural Requirements in the Transmembrane Domain of GLIC Revealed by Incorporation of Noncanonical Histidine Analogs

(2014) Matthew Rienzo et al.   CHEMISTRY & BIOLOGY

Drug-induced ion channel opening tuned by the voltage sensor charge profile

(2014) Nina E. Ottosson et al.   JOURNAL OF GENERAL PHYSIOLOGY

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

X-ray structure of the mouse serotonin 5-HT3 receptor

(2014) Ghérici Hassaine et al.   NATURE

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

(2014) Thorsten Althoff et al.   NATURE

Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

(2014) Smriti Mishra et al.   eLife

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

(2013) Ludovic Sauguet et al.   EMBO JOURNAL

Structural Sensitivity of a Prokaryotic Pentameric Ligand-gated Ion Channel to Its Membrane Environment

(2013) Jonathan M. Labriola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Allosteric Coupling at the Membrane-Protein Interface inGloeobacter violaceusLigand-gated Ion Channel (GLIC)

(2013) Phanindra Velisetty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid

(2013) Toshinori Hoshi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure and gating of tetrameric glutamate receptors

(2013) Alexander I. Sobolevsky   JOURNAL OF PHYSIOLOGY-LONDON

A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors

(2013) Corrie J B daCosta et al.   Nature Chemical Biology

Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography

(2013) G. Gonzalez-Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA

(2013) T. Hoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

(2013) L. Sauguet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: The influence of LCPUFA on neural development, aging, and neurodegeneration

(2013) Carola I.F. Janssen et al.   PROGRESS IN LIPID RESEARCH

An outline of desensitization in pentameric ligand-gated ion channel receptors

(2012) Angelo Keramidas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Conscious processing

(2012) Jean-Pierre G. Changeux   Current Opinion in Anesthesiology

Desensitization Mechanism in Prokaryotic Ligand-gated Ion Channel

(2012) Phanindra Velisetty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Transitions Underlying Pore Opening and Desensitization in Membrane-embeddedGloeobacter violaceusLigand-gated Ion Channel (GLIC)

(2012) Phanindra Velisetty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gating Movement of Acetylcholine Receptor Caught by Plunge-Freezing

(2012) Nigel Unwin et al.   JOURNAL OF MOLECULAR BIOLOGY

A locally closed conformation of a bacterial pentameric proton-gated ion channel

(2012) Marie S Prevost et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

(2012) G. Gonzalez-Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels

(2012) Cristina Moreno et al.   Frontiers in Physiology

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nicotinic acetylcholine receptors as therapeutic targets: Emerging frontiers in basic research and clinical science—Editorial Comments

(2011) Diana Donnelly-Roberts et al.   BIOCHEMICAL PHARMACOLOGY

Engineering a Prokaryotic Cys-loop Receptor with a Third Functional Domain

(2011) Raman Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intramembrane Proton Binding Site Linked to Activation of Bacterial Pentameric Ion Channel

(2011) Hai-Long Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the M2 Transmembrane Segment of GLIC, a Prokaryotic Cys Loop Receptor Homologue fromGloeobacter violaceus, Probed by Substituted Cysteine Accessibility

(2011) Rishi B. Parikh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

(2011) R. J. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Increased Sensitivity and Extended Range of Distance Measurements in Spin-Labeled Membrane Proteins: Q-Band Double Electron-Electron Resonance and Nanoscale Bilayers

(2010) Ping Zou et al.   BIOPHYSICAL JOURNAL

Structural mechanism of C-type inactivation in K+ channels

(2010) Luis G. Cuello et al.   NATURE

Structural basis for the coupling between activation and inactivation gates in K+ channels

(2010) Luis G. Cuello et al.   NATURE

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

(2010) Ricarda J C Hilf et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels

(2010) John E. Baenziger et al.   NEUROPHARMACOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Lipid-dependent Uncoupled Conformation of the Acetylcholine Receptor

(2009) Corrie J. B. daCosta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyunsaturated Fatty Acid Modulation of Voltage-Gated Ion Channels

(2008) Linda M. Boland et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Modulation of Nicotinic Acetylcholine Receptor Conformational State by Free Fatty Acids and Steroids

(2008) Gaspar A. Fernández Nievas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interface between Extracellular and Transmembrane Domains of Homomeric Cys-Loop Receptors Governs Open-Channel Lifetime and Rate of Desensitization

(2008) C. Bouzat et al.   JOURNAL OF NEUROSCIENCE

Desensitization of Nicotinic Acetylcholine Receptors as a Strategy for Drug Development

(2008) J. J. Buccafusco et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Potentiation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2008) G. T. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA