Structure and gating of tetrameric glutamate receptors

An NMDA Receptor Gating Mechanism Developed from MD Simulations Reveals Molecular Details Underlying Subunit-Specific Contributions

(2013) Jian Dai et al.   BIOPHYSICAL JOURNAL

A Conserved Mechanism for Gating in an Ionotropic Glutamate Receptor

(2013) Bryn S. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of Cleft Closure of the GluA2 Ligand-binding Domain in the Presence of Full and Partial Agonists Revealed by Hydrogen-Deuterium Exchange

(2013) Ahmed H. Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles

(2013) Melany N. Lopez et al.   JOURNAL OF GENERAL PHYSIOLOGY

Asynchronous Movements Prior to Pore Opening in NMDA Receptors

(2013) R. Kazi et al.   JOURNAL OF NEUROSCIENCE

A Eukaryotic Specific Transmembrane Segment is Required for Tetramerization in AMPA Receptors

(2013) C. L. Salussolia et al.   JOURNAL OF NEUROSCIENCE

Identification of Functionally Key Residues in AMPA Receptor with a Thermodynamic Method

(2013) Ji Guo Su et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state

(2013) Bryan A. Daniels et al.   JOURNAL OF PHYSIOLOGY-LONDON

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Defining the structural relationship between kainate-receptor deactivation and desensitization

(2013) G Brent Dawe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain

(2013) Shujia Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Conformational Intermediate in Glutamate Receptor Activation

(2013) Albert Y. Lau et al.   NEURON

Modal gating of GluN1/GluN2D NMDA receptors

(2013) Katie M. Vance et al.   NEUROPHARMACOLOGY

Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain

(2013) D. M. Schauder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific Characteristics

(2013) Yongneng Yao et al.   STRUCTURE

Functional Insights from Glutamate Receptor Ion Channel Structures

(2012) Janesh Kumar et al.   Annual Review of Physiology

Role of Conformational Dynamics in α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) Receptor Partial Agonism

(2012) Swarna Ramaswamy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction

(2012) Beth Siegler Retchless et al.   NATURE NEUROSCIENCE

Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface

(2012) Julien Veran et al.   NEURON

Coupled Control of Desensitization and Gating by the Ligand Binding Domain of Glutamate Receptors

(2012) Anna L. Carbone et al.   NEURON

Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism

(2012) Mikko Ylilauri et al.   PLoS One

Domain Architecture of a Calcium-Permeable AMPA Receptor in a Ligand-Free Conformation

(2012) Charles R. Midgett et al.   Frontiers in Molecular Neuroscience

Argiotoxin in the Closed AMPA Receptor Channel: Experimental and Modeling Study

(2011) Oleg I. Barygin et al.   BIOCHEMISTRY

GluN1-Specific Redox Effects on the Kinetic Mechanism of NMDA Receptor Activation

(2011) Iehab Talukder et al.   BIOPHYSICAL JOURNAL

Posttranslational regulation of AMPA receptor trafficking and function

(2011) Wei Lu et al.   CURRENT OPINION IN NEUROBIOLOGY

Dynamics and allosteric potential of the AMPA receptor N-terminal domain

(2011) Madhav Sukumaran et al.   EMBO JOURNAL

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

Mechanism of AMPA Receptor Activation by Partial Agonists

(2011) Ahmed H. Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening

(2011) Iehab Talukder et al.   JOURNAL OF GENERAL PHYSIOLOGY

Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization

(2011) N. Nayeem et al.   JOURNAL OF NEUROSCIENCE

Cations But Not Anions Regulate the Responsiveness of Kainate Receptors

(2011) D. M. MacLean et al.   JOURNAL OF NEUROSCIENCE

Modes of glutamate receptor gating

(2011) Gabriela K. Popescu   JOURNAL OF PHYSIOLOGY-LONDON

Structure and function of glutamate receptor amino terminal domains

(2011) Hiro Furukawa   JOURNAL OF PHYSIOLOGY-LONDON

Mechanisms of Modal Activation of GluA3 Receptors

(2011) K. Poon et al.   MOLECULAR PHARMACOLOGY

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

Structural landscape of isolated agonist-binding domains from single AMPA receptors

(2011) Christy F Landes et al.   Nature Chemical Biology

The hidden energetics of ligand binding and activation in a glutamate receptor

(2011) Albert Y Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and Assembly Mechanism for Heteromeric Kainate Receptors

(2011) Janesh Kumar et al.   NEURON

The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits

(2011) Alexander C. Jackson et al.   NEURON

New advances in NMDA receptor pharmacology

(2011) Kevin K. Ogden et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers

(2011) William F. Borschel et al.   Nature Communications

Atomistic mechanism for the activation and desensitization of an AMPA-subtype glutamate receptor

(2011) Hao Dong et al.   Nature Communications

Characterizing Single-Channel Behavior of GluA3 Receptors

(2010) Kinning Poon et al.   BIOPHYSICAL JOURNAL

On the Mechanisms of α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) Receptor Binding to Glutamate and Kainate

(2010) Michael K. Fenwick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subunit Arrangement inN-Methyl-d-aspartate (NMDA) Receptors

(2010) Anu Rambhadran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of the Glutamate Receptor Ion Channel GluK3 and GluK5 Amino-Terminal Domains

(2010) Janesh Kumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Gating Modes in AMPA Receptors

(2010) M. L. Prieto et al.   JOURNAL OF NEUROSCIENCE

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Role of dimer interface in activation and desensitization in AMPA receptors

(2010) J. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

(2009) Laetitia Mony et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crystal structure and association behaviour of the GluR2 amino-terminal domain

(2009) Rongsheng Jin et al.   EMBO JOURNAL

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit

(2009) Erkan Karakas et al.   EMBO JOURNAL

Crystal Structure of the GluR2 Amino-Terminal Domain Provides Insights into the Architecture and Assembly of Ionotropic Glutamate Receptors

(2009) Amber Clayton et al.   JOURNAL OF MOLECULAR BIOLOGY

Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

(2009) H. Yuan et al.   JOURNAL OF NEUROSCIENCE

AMPA Receptor Ligand Binding Domain Mobility Revealed by Functional Cross Linking

(2009) A. J. R. Plested et al.   JOURNAL OF NEUROSCIENCE

Ion-dependent gating of kainate receptors

(2009) Derek Bowie   JOURNAL OF PHYSIOLOGY-LONDON

A Nondesensitizing Kainate Receptor Point Mutant

(2009) N. Nayeem et al.   MOLECULAR PHARMACOLOGY

Mechanism of differential control of NMDA receptor activity by NR2 subunits

(2009) Marc Gielen et al.   NATURE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Kinetic basis of partial agonism at NMDA receptors

(2009) Cassandra L Kussius et al.   NATURE NEUROSCIENCE

The N-terminal domain of GluR6-subtype glutamate receptor ion channels

(2009) Janesh Kumar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of Partial Agonism at the GluR2 AMPA Receptor: Measurements of Lobe Orientation in Solution†

(2008) Alexander S. Maltsev et al.   BIOCHEMISTRY

Ionotropic Glutamate Receptors & CNS Disorders

(2008) Derek Bowie   CNS & Neurological Disorders-Drug Targets

The Activation Gate and Gating Mechanism of the NMDA Receptor

(2008) H.-R. Chang et al.   JOURNAL OF NEUROSCIENCE

Structural and Single-Channel Results Indicate That the Rates of Ligand Binding Domain Closing and Opening Directly Impact AMPA Receptor Gating

(2008) W. Zhang et al.   JOURNAL OF NEUROSCIENCE

Molecular Basis of Kainate Receptor Modulation by Sodium

(2008) Andrew J.R. Plested et al.   NEURON