Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities
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Title
Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities
Authors
Keywords
Epigenetics, Melanoma, DNA methylation, DNMT, Azacitidine, Biomarker, DNMT1, DNMT3B
Journal
Clinical Epigenetics
Volume 9, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-04-05
DOI
10.1186/s13148-017-0332-8
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Note: Only part of the references are listed.- A comparison of existing global DNA methylation assays to low-coverage whole-genome bisulfite sequencing for epidemiological studies
- (2017) Florence K. Crary-Dooley et al. Epigenetics
- Attenuation of genome-wide 5-methylcytosine level is an epigenetic feature of cutaneous malignant melanomas
- (2017) Goran Micevic et al. MELANOMA RESEARCH
- MicroRNA epigenetic signatures in human disease
- (2016) Klara Piletič et al. ARCHIVES OF TOXICOLOGY
- MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A
- (2016) Haizhou Yu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Comparison of Methyl-capture Sequencing vs. Infinium 450K methylation array for methylome analysis in clinical samples
- (2016) Ai Ling Teh et al. Epigenetics
- Tissue inhibitor of metalloproteinase-3 (TIMP3) expression decreases during melanoma progression and inhibits melanoma cell migration
- (2016) Asha M. Das et al. EUROPEAN JOURNAL OF CANCER
- Enhancer methylation dynamics contribute to cancer plasticity and patient mortality
- (2016) Rachel E. Bell et al. GENOME RESEARCH
- Immunotherapy for advanced melanoma: future directions
- (2016) Sara Valpione et al. Immunotherapy
- Promoter Methylation of PTEN Is a Significant Prognostic Factor in Melanoma Survival
- (2016) Mi Ryung Roh et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- MicroRNA 211 Functions as a Metabolic Switch in Human Melanoma Cells
- (2016) Joseph Mazar et al. MOLECULAR AND CELLULAR BIOLOGY
- LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
- (2016) Filippos Kottakis et al. NATURE
- Allosteric control of mammalian DNA methyltransferases – a new regulatory paradigm
- (2016) Albert Jeltsch et al. NUCLEIC ACIDS RESEARCH
- Integrative discovery of CD98 as a melanoma biomarker
- (2016) Nicholas Theodosakis et al. Pigment Cell & Melanoma Research
- Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma
- (2016) Minggang Fang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Profiling genome-wide DNA methylation
- (2016) Wai-Shin Yong et al. Epigenetics & Chromatin
- DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR
- (2016) Goran Micevic et al. Cell Reports
- miR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1
- (2015) Xiao Chang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Epigenetic regulation of p14ARF and p16INK4A expression in cutaneous and uveal melanoma
- (2015) Mario Venza et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- DNA methylation subgroups in melanoma are associated with proliferative and immunological processes
- (2015) Martin Lauss et al. BMC Medical Genomics
- DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension
- (2015) Jonathan D. Licht CELL
- DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
- (2015) David Roulois et al. CELL
- Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
- (2015) Katherine B. Chiappinelli et al. CELL
- Genomic Classification of Cutaneous Melanoma
- (2015) Rehan Akbani et al. CELL
- Diagnostic utility of 5-hydroxymethylcytosine immunohistochemistry in melanocytic proliferations
- (2015) Nemanja Rodić et al. JOURNAL OF CUTANEOUS PATHOLOGY
- HOXD9 promotes epithelial–mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma
- (2015) Xiupeng Lv et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation
- (2015) Martin Lauss et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- KIT Is a Frequent Target for Epigenetic Silencing in Cutaneous Melanoma
- (2015) Christina Dahl et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- DNA methylation contributes toward silencing of antioncogenic microRNA-203 in human and canine melanoma cells
- (2015) Shunsuke Noguchi et al. MELANOMA RESEARCH
- Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
- (2015) Tuncay Baubec et al. NATURE
- Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
- (2015) Jing Liao et al. NATURE GENETICS
- PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
- (2015) Dung T. Le et al. NEW ENGLAND JOURNAL OF MEDICINE
- A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma
- (2015) Julie Cannuyer et al. Clinical Epigenetics
- Epigenetic reprogramming of melanoma cells by vitamin C treatment
- (2015) Christopher B Gustafson et al. Clinical Epigenetics
- Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma
- (2015) Phil F Cheng et al. GENOME BIOLOGY
- Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma
- (2015) Irfan A Asangani et al. Oncotarget
- Alterations of immune response of non-small cell lung cancer with Azacytidine
- (2015) John Wrangle et al. Oncotarget
- CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity
- (2014) Tara Spence et al. ACTA NEUROPATHOLOGICA
- Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysis
- (2014) Y. Y. Juo et al. ANNALS OF ONCOLOGY
- Methodological aspects of whole-genome bisulfite sequencing analysis
- (2014) S. Adusumalli et al. BRIEFINGS IN BIOINFORMATICS
- Identification of a melanoma susceptibility locus and somatic mutation inTET2
- (2014) Fengju Song et al. CARCINOGENESIS
- MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma
- (2014) Rainer Tuominen et al. INTERNATIONAL JOURNAL OF CANCER
- Clinical development of demethylating agents in hematology
- (2014) Shyamala C. Navada et al. JOURNAL OF CLINICAL INVESTIGATION
- Combination Therapy with Anti–CTLA-4 and Anti–PD-1 Leads to Distinct Immunologic Changes In Vivo
- (2014) Rituparna Das et al. JOURNAL OF IMMUNOLOGY
- Promoter CpG Island Hypermethylation in Dysplastic Nevus and Melanoma: CLDN11 as an Epigenetic Biomarker for Malignancy
- (2014) Linda Gao et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- 5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies
- (2014) Jonathan J Lee et al. MODERN PATHOLOGY
- DNA methylation profiles in primary cutaneous melanomas are associated with clinically significant pathologic features
- (2014) Nancy E. Thomas et al. Pigment Cell & Melanoma Research
- Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome
- (2014) Diego M. Marzese et al. Pigment Cell & Melanoma Research
- DNA Methylation Characteristics of Primary Melanomas with Distinct Biological Behaviour
- (2014) Szilvia Ecsedi et al. PLoS One
- Epigenetics of human melanoma: promises and challenges
- (2014) A. Besaratinia et al. Journal of Molecular Cell Biology
- Acute Depletion Redefines the Division of Labor among DNA Methyltransferases in Methylating the Human Genome
- (2014) Rochelle L. Tiedemann et al. Cell Reports
- Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location
- (2013) J M Bae et al. BRITISH JOURNAL OF CANCER
- Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
- (2013) Cornelia G. Spruijt et al. CELL
- Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis
- (2013) Diego M. Marzese et al. HUMAN MOLECULAR GENETICS
- 5-Hydroxymethylcytosine as a useful marker to differentiate between malignant melanomas and benign melanocytic nevi
- (2013) Ryuhei Uchiyama et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- The Hematopoietic Stem Cell Regulatory Gene Latexin Has Tumor-Suppressive Properties in Malignant Melanoma
- (2013) Viswanathan Muthusamy et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Methylated Tissue Factor Pathway Inhibitor 2 (TFPI2) DNA in Serum Is a Biomarker of Metastatic Melanoma
- (2013) Cristiana Lo Nigro et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- The Role of miR-18b in MDM2-p53 Pathway Signaling and Melanoma Progression
- (2013) Altaf A Dar et al. JNCI-Journal of the National Cancer Institute
- Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents
- (2013) H Yang et al. LEUKEMIA
- Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma
- (2013) Thilo Gambichler et al. MELANOMA RESEARCH
- Mahanine restores RASSF1A expression by down-regulating DNMT1 and DNMT3B in prostate cancer cells
- (2013) Soumik Agarwal et al. Molecular Cancer
- Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR
- (2013) Claudia L Kleinman et al. NATURE GENETICS
- Genome-wide promoter methylation analysis identifies epigenetic silencing ofMAPK13in primary cutaneous melanoma
- (2013) Linda Gao et al. Pigment Cell & Melanoma Research
- Ras and Rac1, Frequently Mutated in Melanomas, Are Activated by Superoxide Anion, Modulate Dnmt1 Level and Are Causally Related to Melanocyte Malignant Transformation
- (2013) Fernanda Molognoni et al. PLoS One
- Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma
- (2012) Christine Guo Lian et al. CELL
- MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System
- (2012) Marian Mellén et al. CELL
- Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome
- (2012) Miao Yu et al. CELL
- The BRAFV600E causes widespread alterations in gene methylation in the genome of melanoma cells
- (2012) Peng Hou et al. CELL CYCLE
- Whole genome methylation profiles as independent markers of survival in stage IIIC melanoma patients
- (2012) Luca Sigalotti et al. Journal of Translational Medicine
- Loss of microRNA-205 expression is associated with melanoma progression
- (2012) Shujing Liu et al. LABORATORY INVESTIGATION
- 5-Aza-2′-deoxycytidine Induced Growth Inhibition of Leukemia Cells through Modulating Endogenous Cholesterol Biosynthesis
- (2012) Fan Zhang et al. MOLECULAR & CELLULAR PROTEOMICS
- Silencing of a large microRNA cluster on human chromosome 14q32 in melanoma: biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor
- (2012) Liron Zehavi et al. Molecular Cancer
- Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
- (2012) Michael Krauthammer et al. NATURE GENETICS
- Prognostic significance of MGMT gene promoter methylation in differently treated metastatic melanomas
- (2012) A.M. Cesinaro et al. PATHOLOGY
- G-Cimp Status Prediction Of Glioblastoma Samples Using mRNA Expression Data
- (2012) Mehmet Baysan et al. PLoS One
- Mutant IDH1 Confers an in Vivo Growth in a Melanoma Cell Line with BRAF Mutation
- (2011) Tatsuhiro Shibata et al. AMERICAN JOURNAL OF PATHOLOGY
- Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D
- (2011) A. Heinemann et al. CANCER RESEARCH
- DNA Demethylation Dynamics
- (2011) Nidhi Bhutani et al. CELL
- Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma
- (2011) Tung Nguyen et al. Epigenetics
- Epigenetic regulation of microRNA-375 and its role in melanoma development in humans
- (2011) Joseph Mazar et al. FEBS LETTERS
- Methylation levels of the "long interspersed nucleotide element-1" repetitive sequences predict survival of melanoma patients
- (2011) Luca Sigalotti et al. Journal of Translational Medicine
- Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
- (2011) William A. Pastor et al. NATURE
- Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling
- (2011) Hongcang Gu et al. Nature Protocols
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- DNA-methylation profiling distinguishes malignant melanomas from benign nevi
- (2011) Kathleen Conway et al. Pigment Cell & Melanoma Research
- Epigenetic Regulation of MicroRNA Genes and the Role of miR-34b in Cell Invasion and Motility in Human Melanoma
- (2011) Joseph Mazar et al. PLoS One
- Cross-Platform Array Screening Identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as Genes Frequently Silenced by Methylation in Melanoma
- (2011) Vanessa F. Bonazzi et al. PLoS One
- DNA Methylation: A Timeline of Methods and Applications
- (2011) Alan Harrison et al. Frontiers in Genetics
- Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
- (2010) Dmitri Lodygin et al. CELL CYCLE
- Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci
- (2010) Anthony P. Popkie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transcriptional and post-transcriptional control of DNA methyltransferase 3B is regulated by phosphatidylinositol 3 kinase/Akt pathway in human hepatocellular carcinoma cell lines
- (2010) Chuanzhong Mei et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- High Frequency of p16INK4A Promoter Methylation in NRAS-Mutated Cutaneous Melanoma
- (2010) Anders Jonsson et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies
- (2010) Luca Sigalotti et al. Journal of Translational Medicine
- Aberrant DNA methylation in malignant melanoma
- (2010) Carolina Schinke et al. MELANOMA RESEARCH
- Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
- (2010) Shinsuke Ito et al. NATURE
- An essential role for DNA methyltransferase 3a in melanoma tumorigenesis
- (2009) Tao Deng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Targeting DNA Methylation
- (2009) J.-P. J. Issa et al. CLINICAL CANCER RESEARCH
- CpG Island Methylator Phenotype Predicts Progression of Malignant Melanoma
- (2009) A. Tanemura et al. CLINICAL CANCER RESEARCH
- Differential Clinical Significance of Individual NKG2D Ligands in Melanoma: Soluble ULBP2 as an Indicator of Poor Prognosis Superior to S100B
- (2009) A. Paschen et al. CLINICAL CANCER RESEARCH
- Genome-wide screen of promoter methylation identifies novel markers in melanoma
- (2009) Y. Koga et al. GENOME RESEARCH
- Final Version of 2009 AJCC Melanoma Staging and Classification
- (2009) Charles M. Balch et al. JOURNAL OF CLINICAL ONCOLOGY
- Methylation of PTEN as a Prognostic Factor in Malignant Melanoma of the Skin
- (2009) Christoph Lahtz et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- CpG island methylation profiling in human melanoma cell lines
- (2009) Carmen S. Tellez et al. MELANOMA RESEARCH
- MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
- (2009) Michael Weller et al. Nature Reviews Neurology
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
- (2009) M. Tahiliani et al. SCIENCE
- Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma
- (2008) Vanessa F. Bonazzi et al. GENES CHROMOSOMES & CANCER
- Frequent p16-Independent Inactivation of p14ARF in Human Melanoma
- (2008) Daniel E. Freedberg et al. JNCI-Journal of the National Cancer Institute
- Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection
- (2008) L. S. Kristensen et al. NUCLEIC ACIDS RESEARCH
- Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling
- (2008) Suhu Liu et al. Pigment Cell & Melanoma Research
- A microRNA DNA methylation signature for human cancer metastasis
- (2008) A. Lujambio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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