Quality by control: Towards model predictive control of mammalian cell culture bioprocesses

A review of control strategies for manipulating the feed rate in fed-batch fermentation processes

(2017) Lisa Mears et al.   JOURNAL OF BIOTECHNOLOGY

Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

(2016) Karen A. Esmonde-White et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Controlling the time evolution of mAb N-linked glycosylation - Part II: Model-based predictions

(2016) Thomas K. Villiger et al.   BIOTECHNOLOGY PROGRESS

Toward intensifying design of experiments in upstream bioprocess development: An industrialEscherichia colifeasibility study

(2016) Moritz von Stosch et al.   BIOTECHNOLOGY PROGRESS

Towards Process Spectroscopy in Complex Fermentation Samples and Mixtures

(2016) Andrea Paul et al.   CHEMIE INGENIEUR TECHNIK

A methodology for direct exploitation of available information in the online model-based redesign of experiments

(2016) Riccardo De-Luca et al.   COMPUTERS & CHEMICAL ENGINEERING

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

(2016) Hooman Hefzi et al.   Cell Systems

Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation

(2015) Viki R Chopda et al.   Biotechnology Journal

Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors

(2015) Hamidreza Mehdizadeh et al.   BIOTECHNOLOGY PROGRESS

Mathematical Modelling as a Tool for Optimized PHA Production

(2015) M. Novak   CHEMICAL AND BIOCHEMICAL ENGINEERING QUARTERLY

Sensor systems for bioprocess monitoring

(2015) Philipp Biechele et al.   ENGINEERING IN LIFE SCIENCES

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

(2015) Levente L. Simon et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media

(2015) Julien Robitaille et al.   PLoS One

Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation

(2015) Viki R Chopda et al.   Biotechnology Journal

Fluorescence-based soft sensor for at situ monitoring of chinese hamster ovary cell cultures

(2014) Kaveh Ohadi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Development of a soft-sensor based on multi-wavelength fluorescence spectroscopy and a dynamic metabolic model for monitoring mammalian cell cultures

(2014) Kaveh Ohadi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Hybrid modeling for quality by design and PAT-benefits and challenges of applications in biopharmaceutical industry

(2014) Moritz von Stosch et al.   Biotechnology Journal

Guidance for performing multivariate data analysis of bioprocessing data: Pitfalls and recommendations

(2014) Anurag S. Rathore et al.   BIOTECHNOLOGY PROGRESS

Towards real-time monitoring of therapeutic protein quality in mammalian cell processes

(2014) Daniel A.M. Pais et al.   CURRENT OPINION IN BIOTECHNOLOGY

Multivariate analysis of the effect of operating conditions on hybridoma cell metabolism and glycosylation of produced antibody

(2014) Amy Green et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Mini-review: soft sensors as means for PAT in the manufacture of bio-therapeutics

(2014) Carl-Fredrik Mandenius et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller

(2014) Stephen Craven et al.   JOURNAL OF PROCESS CONTROL

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

A Soft Sensor for Bioprocess Control Based on Sequential Filtering of Metabolic Heat Signals

(2014) Dan Paulsson et al.   SENSORS

Simultaneous solution approach to model-based experimental design

(2013) M. D. Hoang et al.   AICHE JOURNAL

Design of experiments applications in bioprocessing: Concepts and approach

(2013) Vijesh Kumar et al.   BIOTECHNOLOGY PROGRESS

Hybrid semi-parametric modeling in process systems engineering: Past, present and future

(2013) Moritz von Stosch et al.   COMPUTERS & CHEMICAL ENGINEERING

Dynamic process conditions in bioprocess development

(2013) Oliver Spadiut et al.   ENGINEERING IN LIFE SCIENCES

Model-based design of experiments for cellular processes

(2013) Ankush Chakrabarty et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

BIOPROCESS SYSTEMS ENGINEERING: TRANSFERRING TRADITIONAL PROCESS ENGINEERING PRINCIPLES TO INDUSTRIAL BIOTECHNOLOGY

(2013) Michalis Koutinas et al.   Computational and Structural Biotechnology Journal

Integrated continuous production of recombinant therapeutic proteins

(2012) Veena Warikoo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Soft sensors in bioprocessing: A status report and recommendations

(2012) Reiner Luttmann et al.   Biotechnology Journal

Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach

(2012) Alex Eon-Duval et al.   BIOTECHNOLOGY PROGRESS

Dynamic modeling of methylotrophic Pichia pastoris culture with exhaust gas analysis: From cellular metabolism to process simulation

(2012) Hongxing Niu et al.   CHEMICAL ENGINEERING SCIENCE

A Bayesian inference based two-stage support vector regression framework for soft sensor development in batch bioprocesses

(2012) Jie Yu   COMPUTERS & CHEMICAL ENGINEERING

Increasing batch-to-batch reproducibility of CHO-cell cultures using a model predictive control approach

(2012) Mathias Aehle et al.   CYTOTECHNOLOGY

Dynamic metabolic models of CHO cell cultures through minimal sets of elementary flux modes

(2012) F. Zamorano et al.   JOURNAL OF BIOTECHNOLOGY

Experimental design in chromatography: A tutorial review

(2012) D. Brynn Hibbert   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Synchronous fluorescence spectroscopy as a novel tool to enable PAT applications in bioprocesses

(2011) Ana P. Teixeira et al.   BIOTECHNOLOGY AND BIOENGINEERING

Simplified off-gas analyses in animal cell cultures for process monitoring and control purposes

(2011) Mathias Aehle et al.   BIOTECHNOLOGY LETTERS

Application of quality by design principles to the development and technology transfer of a major process improvement for the manufacture of a recombinant protein

(2011) Mairead Looby et al.   BIOTECHNOLOGY PROGRESS

A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus

(2011) Ioscani Jimenez del Val et al.   BIOTECHNOLOGY PROGRESS

Metabolic Flux and the Regulation of Mammalian Cell Growth

(2011) Jason W. Locasale et al.   Cell Metabolism

Mechanistic pathway modeling for industrial biotechnology: challenging but worthwhile

(2011) Wolfgang Wiechert et al.   CURRENT OPINION IN BIOTECHNOLOGY

Model predictive control: Review of the three decades of development

(2011) Jay H. Lee   INTERNATIONAL JOURNAL OF CONTROL AUTOMATION AND SYSTEMS

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Dynamic model of CHO cell metabolism

(2010) Ryan P. Nolan et al.   METABOLIC ENGINEERING

Data-driven Soft Sensors in the process industry

(2009) Petr Kadlec et al.   COMPUTERS & CHEMICAL ENGINEERING

Genome-scale modeling and in silico analysis of mouse cell metabolic network

(2009) Suresh Selvarasu et al.   Molecular BioSystems

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

Nonlinear Multivariate Quality Estimation and Prediction Based on Kernel Partial Least Squares

(2008) Xi Zhang et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Model-based design of experiments for parameter precision: State of the art

(2007) Gaia Franceschini et al.   CHEMICAL ENGINEERING SCIENCE